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Selected publications from the last 7 years:

DeCarlo, L., Prakasha Gowda, A. S., Suo, Z. and Spratt, T. E.* (2008) Formation of purine-purine mispairs by Sulfolobus solfataricus DNA polymerase IV, Biochemistry, 47, 8157-8164.

Brown, J. A., Newmister, S. A., Fiala, K. A., and Suo, Z.* (2008) Mechanism of Double-Base Lesion Bypass Catalyzed by a Y-Family DNA Polymerase, Nucleic Acids Research 36, 3867-3878. (pdf)

Wong, J. H. Y., Fiala, K. A., Suo, Z. & Ling, H.* (2008) Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4, J. Mol. Biol. 379, 317-330. (pdf)

Fowler, J. D., Brown, J.A., Johnson, K.A. and Suo, Z* (2008) Kinetic Investigation of the Inhibitory Effect of Gemcitabine on DNA Polymerization Catalyzed by Human Mitochondrial DNA Polymerase. J. Biol. Chem. 283, 15339-15348. (pdf)

Fiala, K. A., Sherrer, S. M., Brown, J. A., and Suo, Z.* (2008) Mechanistic consequences of temperature on DNA polymerization catalyzed by a Y-family DNA polymerase, Nucleic Acids Research 36, 1990-2001. (pdf)

Brown, J., Duym, W. W., Fowler, J. D., and Suo, Z* (2007) Single-Turnover Kinetic Analysis of the Mutagenic Potential of 7,8-Dihydro-8-oxoguanine During Gap-Filling Synthesis Catalyzed by Human DNA Polymerases Lambda and Beta, J. Mol. Biol. (pdf)

Fiala, K. A., Brown, J. A., Ling, H., Kshetry, A. K., Zhang, J., Taylor, J.-S., Yang, W. and Suo, Z* (2007) Mechanism of Template-Independent Nucleotide Incorporation Catalyzed by a Template-Dependent DNA Polymerase. J. Mol. Biol. 365, 598-610. (pdf)

Fiala, K. A., Hypes, C., and Suo, Z* (2007) Mechanism of Abasic Lesion Bypass Catalyzed by a Y-Family DNA Polymerase, J. Biol. Chem. (pdf) [Press Release]

Fiala, K. A. and Suo, Z* (2007) Sloppy Bypass of an Abasic Lesion Catalyzed by a Y-Family DNA Polymerase as Revealed by a Novel Cell-Based Short Oligonucleotide Sequencing Assay. J. Biol. Chem. (pdf) [Press Release]

Abdullah, M. A. F. and Suo, Z* (2007) Unique composite active site of the Hepatitis C virus NS2-3 protease: a new opportunity for antiviral drug design. ChemMedChem. (pdf)

Duym, W. W., Fiala, K. A., Bhatt N., and Suo, Z* (2006) Kinetic Effect of a Downstream Strand and Its 5’-Terminal Moieties on Single-Nucleotide Gap-Filling Synthesis Catalyzed by Human DNA Polymerase Lambda. J. Biol. Chem. 281, 35649–35655. (pdf)

Fiala, K.A., et al. (2006) Up-regulation of the fidelity of human DNA polymerase lambda by its non-enzymatic proline-rich domain. J Biol Chem. 281, 19038-44. (pdf) [Press Release]

Fowler, J.D. and Z. Suo (2006) Biochemical, structural, and physiological characterization of terminal deoxynucleotidyl transferase. Chem Rev, 2006. 106(6): p. 2092-110. (pdf)

Suo, Z* (2005) "Thioesterase Portability and Peptidyl Carrier Protein Swapping in Yersiniabactin Synthetase from Yersinia pestis". Biochemistry, 44, 4926-4938. (pdf)

Johnson, A. A., Fiala, K. A. and Suo, Z.* (2005) “Chapter 6: DNA Polymerases and Their Interactions with DNA and Nucleotides”, pp133-168. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Abdel-Gawad, W., Tan, S. L. and Suo, Z.* (2005) “Chapter 7: RNA polymerases”, pp169-206. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Wang, L. and Suo, Z.* (2005) “Chapter 8: Reverse Transcriptase”, pp207-246. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Fiala, K. A & Suo, Z* (2004) Pre-Steady State Kinetic Studies of the Fidelity of Sulfolobus solfataricus P2 DNA Polymerase IV. Biochemistry 43, 2106-2115 (pdf)

Zhang G. & Suo, Z* (2004) A Mild and Convenient Synthetic Method for Arylhydrazones of Methyl Benzoate. Synthetic Communications 34 (4), 673-678. (pdf)

Fiala, K. A, Abdel-Gawad, W. & Suo, Z* (2004) Pre-Steady-State Kinetic Studies of the Fidelity and Mechanism of Polymerization Catalyzed by Truncated Human DNA Polymerase Lambda. Biochemistry 43, 6751-6762.(pdf)

Roettger, M. P., Fiala, K. A., and Suo. Z* (2004) Fidelity of Human DNA Polymerase Mu. Biochemistry 43, 13827-13838. (pdf)

Allison, A. J., Ray, A., Suo, Z., Colacino, J. M., Andeson, K. S., Johnson, K.A. (2001) "Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase", J. Biol. Chem. 276, 40847-40857.

Suo, Z., Tseng, C., & Walsh, C. T. (2001) "Purification, Priming, and Catalytic Acylation of Carrier Protein Domains in the Polyketide Synthase and Nonribosomal Peptidyl Synthetase Modules of the HMWP1 Subunit of Yersiniabactin Synthetase", Proc. Natl. Acad. Sci. U.S.A. 98, 99-104.

Suo, Z., Chen, H., & Walsh, C. T. (2000) "Acyl CoA Hydrolysis by the HMWP1 Subunit of Yersiniabactin Synthetase: Mutational Evidence for A Cascade of Four Acyl-Enzyme Intermediates during Hydrolytic Editing", Proc. Natl. Acad. Sci. U.S.A. 97, 14188-14193.

Keating, T. A., Suo, Z., Ehmann, D. D., & Walsh, C. T. (2000) "Selectivity of the Yersiniabactin Synthetase Adenylation Domain in the Two Step Process of Amino Acid Activation and Transfer to a Holo-Carrier Protein", Biochemistry 39, 2297-2306.