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Publications from the last 9 years:

Brown, J.A., Fiala, K.A., Fowler, J.D., Sherrer, S.M., Newmister, S.A., Duym, W.W. and Suo Z.* (2009) A Novel Mechanism of Sugar Selection Utilized by a Human X-family DNA Polymerase, J. Mol. Biol. Accepted. (pdf)

Xu, C., Maxwell, B.A., Brown, J.A., Zhang, L. and Suo Z.* (2009) Global Conformational Dynamics of a Y-family DNA Polymerase during Catalysis, PLoS Biology 7(10): e1000225. (pdf)

Brown, J.A. and Suo Z.* (2009) Elucidating the Kinetic Mechanism of DNA Polymerization Catalyzed by Sulfolobus solfataricus P2 DNA Polymerase B1, Biochemistry 48, 7502-7511. (pdf)

Zhang, L., Brown, J.A., Newmister, S.A. and Suo Z.* (2009) Polymerization Fidelity of a Replicative DNA Polymerase from the Hyperthermophilic Archaeon Sulfolobus solfataricus P2, Biochemistry 48, 7492-7501. (pdf)

Fowler J.D., Brown, J.A., Kvaratskhelia, M. and Suo Z.* (2009) Probing Conformational Changes of Human DNA Polymerase Lambda using Mass Spectrometry-Based Protein Footprinting, J. Mol. Biol. 390, 368-379. (pdf)

Sherrer S.M., Brown J.A., Pack L.R., Jasti V.P., Fowler J.D., Basu A.K., and Suo Z.* (2009) Mechanistic Studies of the Bypass of a Bulky Single-Base Lesion Catalyzed by a Y-family DNA Polymerase, J. Biol. Chem. 284, 6379-8863. (pdf)

DeCarlo, L., Prakasha Gowda, A.S., Suo, Z. and Spratt, T.E.* (2008) Formation of Purine-Purine Mispairs by Sulfolobus solfataricus DNA Polymerase IV, Biochemistry 47, 8157-8164. (pdf)

Brown, J.A., Newmister, S.A., Fiala, K.A. and Suo, Z.* (2008) Mechanism of Double-Base Lesion Bypass Catalyzed by a Y-family DNA Polymerase, Nucleic Acids Research 36, 3867-3878. (pdf)

Wong, J.H., Fiala, K.A., Suo, Z. and Ling, H.* (2008) Snapshots of a Y-family DNA Polymerase in Replication: Substrate-Induced Conformational Transitions and Implications for Fidelity of Dpo4, J. Mol. Biol. 379, 317-330. (pdf)

Fowler, J.D., Brown, J.A., Johnson, K.A. and Suo, Z.* (2008) Kinetic Investigation of the Inhibitory Effect of Gemcitabine on DNA Polymerization Catalyzed by Human Mitochondrial DNA Polymerase. J. Biol. Chem. 283, 15339-15348. (pdf)

Fiala, K.A., Sherrer, S.M., Brown, J.A. and Suo, Z.* (2008) Mechanistic Consequences of Temperature on DNA Polymerization Catalyzed by a Y-family DNA Polymerase, Nucleic Acids Research 36, 1990-2001. (pdf)

Brown, J.A., Duym, W.W., Fowler, J.D. and Suo, Z.* (2007) Single-Turnover Kinetic Analysis of the Mutagenic Potential of 7,8-Dihydro-8-oxoguanine during Gap-Filling Synthesis Catalyzed by Human DNA Polymerases Lambda and Beta, J. Mol. Biol. 367, 1258-1269. (pdf)

Fiala, K.A., Brown, J.A., Ling, H., Kshetry, A.K., Zhang, J., Taylor, J.-S., Yang, W. and Suo, Z.* (2007) Mechanism of Template-Independent Nucleotide Incorporation Catalyzed by a Template-Dependent DNA Polymerase, J. Mol. Biol. 365, 598-610. (pdf)

Fiala, K.A., Hypes, C. and Suo, Z.* (2007) Mechanism of Abasic Lesion Bypass Catalyzed by a Y-family DNA Polymerase, J. Biol. Chem.282, 8188-8198. (pdf) [Press Release]

Fiala, K.A. and Suo, Z.* (2007) Sloppy Bypass of an Abasic Lesion Catalyzed by a Y-family DNA Polymerase. J. Biol. Chem. 282, 8199-8206. (pdf) [Press Release]

Abdullah, M.A.F. and Suo, Z.* (2007) Unique Composite Active Site of the Hepatitis C Virus NS2-3 Protease: A New Opportunity for Antiviral Drug Design. Chem. Med. Chem. 2, 283-284. (pdf)

Duym, W.W., Fiala, K.A., Bhatt N. and Suo, Z.* (2006) Kinetic Effect of a Downstream Strand and Its 5’-Terminal Moieties on Single-Nucleotide Gap-Filling Synthesis Catalyzed by Human DNA Polymerase Lambda. J. Biol. Chem. 281, 35649–35655. (pdf)

Fiala, K.A., Duym, W.W., Zhang, J. and Suo, Z.* (2006) Up-regulation of the Fidelity of Human DNA Polymerase Lambda by Its Non-enzymatic Proline-rich Domain, J. Biol. Chem. 281, 19038-44. (pdf) [Press Release]

Fowler, J.D. and Suo, Z.* (2006) Biochemical, Structural, and Physiological Characterization of Terminal Deoxynucleotidyl Transferase. Chem. Rev., 106(6), 2092-110. (pdf)

Suo, Z.* (2005) Thioesterase Portability and Peptidyl Carrier Protein Swapping in Yersiniabactin Synthetase from Yersinia pestis. Biochemistry 44, 4926-4938. (pdf)

Johnson, A.A., Fiala, K.A. and Suo, Z.* (2005) Chapter 6: DNA Polymerases and Their Interactions with DNA and Nucleotides, pp133-168. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Abdel-Gawad, W., Tan, S. L. and Suo, Z.* (2005) Chapter 7: RNA polymerases, pp169-206. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Wang, L. and Suo, Z.* (2005) Chapter 8: Reverse Transcriptase, pp207-246. In M. M. Vaghefi (ed.), Nucleoside Triphosphates and their Analogs: Chemistry, Biotechnology, and Biological Applications, Marcel Dekker, New York, NY.

Fiala, K.A. and Suo, Z.* (2004) Pre-Steady State Kinetic Studies of the Fidelity of Sulfolobus solfataricus P2 DNA Polymerase IV, Biochemistry 43, 2106-2115. (pdf)

Zhang G. and Suo, Z.* (2004) A Mild and Convenient Synthetic Method for Arylhydrazones of Methyl Benzoate, Synthetic Communications 34 (4), 673-678. (pdf)

Fiala, K.A., Abdel-Gawad, W. and Suo, Z.* (2004) Pre-Steady-State Kinetic Studies of the Fidelity and Mechanism of Polymerization Catalyzed by Truncated Human DNA Polymerase Lambda, Biochemistry 43, 6751-6762. (pdf)

Roettger, M.P., Fiala, K.A. and Suo. Z.* (2004) Fidelity of Human DNA Polymerase Mu, Biochemistry 43, 13827-13838. (pdf)

Allison, A.J., Ray, A., Suo, Z., Colacino, J.M., Andeson, K.S. and Johnson, K.A. (2001) Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase, J. Biol. Chem. 276, 40847-40857.

Suo, Z., Tseng, C. and Walsh, C.T. (2001) Purification, Priming, and Catalytic Acylation of Carrier Protein Domains in the Polyketide Synthase and Nonribosomal Peptidyl Synthetase Modules of the HMWP1 Subunit of Yersiniabactin Synthetase, Proc. Natl. Acad. Sci. U.S.A. 98, 99-104.

Suo, Z., Chen, H. and Walsh, C. T. (2000) Acyl CoA Hydrolysis by the HMWP1 Subunit of Yersiniabactin Synthetase: Mutational Evidence for A Cascade of Four Acyl-Enzyme Intermediates during Hydrolytic Editing, Proc. Natl. Acad. Sci. U.S.A. 97, 14188-14193.

Keating, T.A., Suo, Z., Ehmann, D.D. and Walsh, C.T. (2000) Selectivity of the Yersiniabactin Synthetase Adenylation Domain in the Two Step Process of Amino Acid Activation and Transfer to a Holo-Carrier Protein, Biochemistry 39, 2297-2306.