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(6) Effects of HCV Protease NS3/4A on Human Kinases Involved in Immune Response

Virus infection signals antiviral response through transcription factors, nuclear factor k-B (NFkB) and interferon regulatory factors (IRFs). Current treatment includes interferon-a (IFN-a) based therapy that amplifies host antiviral response. In contrast, HCV has evolved unknown mechanisms to disrupt the host response to IFN-a. To examine the effect of HCV protease NS3/4A on these pathways, we are collaborating with Dr. T. Maniatis at Harvard University to elucidate these novel pathways.

(1) Pre-Steady State Kinetic Studies of DNA Lesion Bypass Polymerases

(2) Kinetic and Protein-Protein Interaction Studies of Human DNA Polymerases l, µ and TdT

(3) Mechanistic Studies of Vaccinia Virus DNA Polymerases and Design/Synthesis of Novel Nucleoside Analog Inhibitors

(4) Design and Synthesis of Novel Nucleoside Analog Inhibitors

(5) Developing Anti-HCV Peptide-Based Inhibitors

(6) Effects of HCV Protease NS3/4A on Human Kinases Involved in Immune Response