Chemistry Department Graduates
(College of Math & Physical Sciences)
AS OF june 2008

• Adefarati, Akin - M.S., WI88
  Advisor: Dr. Heinz Floss
  Thesis Title: Isolation, structure elucidation and biosynthesis of a new polyketide-derived metaolite of Streptomyces coelicolor mutant B40.

• Beebe, Kirk - Ph.D., AU2000
  Advisor:  Dr. Dehua Pei
  Dissertation Title:  Substrate recognition through modular domains:  protein tyrosine phosphatase SHP-1 and tail-specific protease (TSP).
  Employment: Post -Doctoral Fellow at Scripps Research Institute

• Biswas, Roopa - Ph.D., SP97
  Advisor:  Dr. Muttaiya Sundaralingam
  Dissertation/Thesis Title: Crystal Structures of Alternating RNA Oligomers:
  Tandem G-U Wobble Pairs.
  Employment: Post-Doc in the lab of Dr. Venkat Gopalan, Dept. of Biochemistry, Ohio State University
  Current Position:  Assistant Professor, Uniformed Services University of the Health Sciences, Graduate School of Nursing

• Bullinger, Patrick - M.S., SU98
  Advisor:  Dr. Ross Dalbey
  Dissertation/Thesis Title: Purification and Activity Studies on a Soluble Fragment of
  Type I Signal Peptidase from Bacillus subtilis.
  Employment: Scientific Information Analyst, Chemical Abstracts, Columbus, Ohio

• Cao, Guoqing - Ph.D., WI95
  Advisor:   Dr. Ross Dalbey
  Dissertation/Thesis Title: Studies on the membrane protein assembly in Eschericha Coli: N-terminal tail translocation and the role of the electrochemical potential in membrane insertion.
  Employment: Postdoctoral Fellowship, Univ. of Texas Southwestern Medical Center

• Carlos, Joseph - Ph.D., AU2000
  Advisor:  Dr. Ross Dalbey
  Dissertation Title:  Type I Signal Peptidases of E. coli, B. subtilis, and S. pneumoniae:  Mechanistic Analysis, Isolation, and Characterization.
  Employment: Employed as Research Scientist by Ross Labs, Columbus, Ohio

• Minyong Chen - Ph.D., AU 2002
  Advisor:  Dr. Ross Dalbey
  Dissertation Title: 
  Employment: Post-Doctoral Fellow, Chemistry Dept., The Ohio
  State University

• Cheng, Shiyuan - Ph.D., SU92
  Advisor:  Dr. Ross Dalbey
  Dissertation Title: Membrane assembly studies of subunit h: leader peptidase
  and m13 procoat proteins in Escherichia Coli.

• DeFelippis, Michael - Ph.D., SP90
  Advisor:  Dr. Michael Klapper
  Dissertation Title: The Redox Potentials of the Tyrosine and Tryptophan Radicals and Long-range Electron Transfer Between Tyrosine and Tryptophan in Peptides.

• Hamilton, Kelly - M.S., SU91
  Advisor:  Dr. Ming-Daw Tsai
  Thesis Title: Structure-function studies on surface lysines of bovine pancreatic phospholipase A2.
  Current Position:  Research Assistant, Johns Hopkins Allergy and Asthma Center
  (with Dr. Farhad Imani)

• Heiny, Layne - M.S., WI87 (Dr. Marita King, Advisor)
  Thesis Title: Chemical modification of the Ca2+- and calmodulin-regulated phosphatase, calcineurin.

• Herrold, Richard - M.S., SU86
  Advisor:  Dr. Heinz Floss
  Thesis Title: Studies on the biosynthesis of asukamycin and acarbose.

• Hu, Xintong - M.S., SU93
  Adviosor:  Dr. Ross Dalbey
  Thesis Title: Positively charged residues influence the PF3 coat protein insertion and topology.

• Huang, Baohua - Ph.D., SU95
  Advisor:  (Dr. Ming-Daw Tsai
  Dissertation Title: Protein Engineering: From Structure-Function Relation Studies of Phospholipase A2 to Rational Design of a Novel Restriction Endonuclease
  Current Position:  Post-Doctoral Fellow, Abbott Laboratories

• Husman, David - Ph.D., SU88
  Advisor:  Dr. Robert Mayer
  Dissertation Title: Removal of detergents from dextrasucrase and the effects they have
  on enzyme activity and structure.
  
  
• Jin, Yan - Ph.D., SU 06
  Advisor: Dr. James Cowan
  Dissertation: In Vitro and In Vivo Studies of DNA Cleavage and Targteted Cleavage of HIV Rev Response Element RNA by Metallopeptides
  Employment: Post-Doctoral Fellow, Ohio State University

• Jou, Ruwen - Ph.D., AU91
  Advisor:  Dr. James Cowan
  Dissertation Title: Metallobiochemistry of ribonuclease H and mannuron C-5 epimerase.

• Kwak, Jae-Gyu - M.S., WI91
  Advisor:  Dr. Ming-Daw Tsai
  Thesis Title: Studies on the Function of Aspartate 99 and Lysine 56 of Bovine Pancreatic Phospholipase A2
  Current Position:  American Cyanamide

• Kwiatkowski, Anne - Ph.D., AU88
  Advisor:  Dr. Marita King
  Dissertation Title: Structure, function and regulation of type II calmodulin-dependant protein kinase.

• Laws, Joan - M.S., AU89
  Advisor:  Dr. Ross Dalbey
  Thesis Title: Polar residues can play a role in membrane translocation.

• Lee, Jong-In - Ph.D., SU91
  Advisor:  Dr. Ross Dalbey
  Dissertation Title: Membrane assembly and function of Escherichia coli leader peptidase.

• Li, Yishan - Ph.D., SU94
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title: Structure-function studies of phospholipase A2: a site-directed mutagenesis and nuclear magnetic resonance study.
  Current Position:  Group Leader, Peptide-Antibody Development, Santa Cruz Biotechnology, Santa Cruz, CA

• Liao, Hua - Ph.D., AU99
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title:  Structure and Function of FHA2 Domain of RAD53, a New Phosphopeptide Binding Domain and Mechanistic Studies of   Phosphatidylinositio-Specific Phospholipase"
  Employment:Postdoc, Harvard Institute of Proteomics at Harvard Medical School
  Current Position:  Millenium Pharmaceuticals

• Liu, Xiaohong - Ph.D., SU96
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title: Structure-function relationship studies of bovine pancreatic phospholipase A2 and chicken muscle adenylate kinase.
  Current Position:  Postdoctoral Fellow at Harvard Medical School
  
  
• Liu, Yushi - Ph.D., SP 07
  Advisor: Dr. James Cowan, Chemsitry Department
  Dissertation Title: Characterization of the Human NFU and its Interaction with the Molecular Chaperone System"
  Position:

• Makroglou, George - M.S., AU87
  Advisor:  Dr. Heinz Floss
  Dissertation Title: Studies in the steric course of the methylation of DNA and model compounds by N-methyl-N-nitrosourea and N, N-dimethylnitrosamine carrying chiral methyl groups.

• Mamone, Anthony - M.S., AU90
  Advisor:  Dr. Ming-Daw Tsai
  Thesis Title: Testing the function of the conserved residue phenylalanine106 of bovine pancreatic phospholipase A2.
  Current Position: U.S. Biochemicals, Cleveland, Ohio

• Mansy, Sheref - Ph.D., SU 03
  Advisor:  Dr. James Cowan
  Dissertation Title:  Structure and Function of Iron-Sulfur Cluster Biosynthesis Proteins and the Influence of Oxygen Ligation
  Position after graduation:  Post-Doctoral Associate, Mass. General Hospital, Harvard University 

• Melillo, Allegra - M.S., SP98
  Advisor:  Dr. Ming-Daw Tsai
  Thesis Title: Protein Engineering: Using Site-Directed Mutagenesis To Improve The Catalytic Efficiency Of A Novel Restriction Endonuclease: Splase.
  Employment: Enrolled in Medical School, Baylor University

• Nuth, Manunya - Ph.D. SU04
  Advisor:  Dr. James Cowan
  Employment: Post-Doctoral Researcher, University of Pennsylvania,
  School of Biomedical Engineering

• Paul O'Maille - Ph.D. Au 2001
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title:  Combinatorial protein engineering by structure-based gene shuffling
  Employment: Post-Doctoral Fellow, Chemistry Department, Ohio State University:

• Oths, Phil - M.S., WI88
  Advisor:  Dr. Heniz Floss
  Thesis Title: Investigation into the stereochemical course of the reaction catalyzed by GDP-mannose oxidoreductase.

• Plank-Herrick, Minnie - M.S., SU93
  Advisor:  Dr. Marita King
  Dissertation/Thesis Title: Chemical modification of calcineurin and the production of its recombinant catalytic subunit.
  Employment: High School Teacher

• Poi, Ming Jye - Ph.D., AU 2001
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title:  Low barrier hydrogen bonding in bovine pancreatic phospholipase A2 and somatic INK4A-ARF locus mutations:  a significant mechanism of gene inactivation in head and neck squamous cell carcinomas.
  Employment: Attending Ohio State University for Pharmacy Degree

• Politino, Michael - Ph.D., SU89
  Advisor:  Dr. Marita King
  Dissertation Title: Calcium- and calmodulin-sensitive interactions of calcineurin with phospholipids.

• Qin, Dongyan  - Ph.D., SU 03
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title:  Specificity and Structural Moedling of FHA domain of CHK2 and a General Characterization of FHA Domain of Caenor Habditis Elegans
  Current Position:  Postodoctoral Fellow, Dept. of Chemistry, The Ohio State University

• Riddle, Suzette - Ph.D., WI97
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title: Purification and characterization of 2 recombinant proteins: annexin 3 and phosphatidyl inositol specific phospholipase.
  Current Position:  Postdoctoral Fellow/Research Associate at National Jewish Institute for Respiratory and Immunological Research (W. Dr. Carl White, M.D.)

• Samuelson, James - Ph.D., AU2000
  Advisor:  Dr. Ross Dalbey
  Dissertation Title: The Essential Role of YidC in Bacterial Protein Insertion
  Employment: Post-Doctoral Fellow, New England Biolabs, Beverly, MD

• Sarvis, Harry - Ph.D., SP90
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title: Physical studies of thiophospholipids using Fourier transform infrared spectroscopy.
  Employment: Director, Ohio Environmental Protection Agency

• Schaeffer, Chris - Ph.D., SP98
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title: Characterization of New Restriction Endonuclease: Splase.
  Employment: Medical student, University of Cincinnati
  Current Position:  Resident - Radiology, Cleveland Clinic
  
  
• Sen, Sabrina - M.S. - SP 07
  Advisor: Dr. Ross Dalbey
  

• Shin, Jinu - M.S., SU99
  Advisor:  Dr. Dehua Pei
  Thesis Title:  Substrate Recognition Through a PDZ Domain in Tail Specific Protease
  
  
• Song, Haiyan - Ph.D., WI08
  Advisor: Dr. Ming-Daw Tsai
  Dissertation: Structural and Functional Study of the Interaction Between KI67 FHA Domain and NIFK

• Suzuki, Erika - Ph.D., SU93
  Advisor:  Dr. Marita King
  Dissertation/Thesis Title: Structure, function, and regulation of type 2 calmodulin-dependent protein kinase
  
  
• Sweeney, Michael - Ph.D. SU 05
  Advisor: Dr. Dehua Pei
  Dissertation: Synthetic Combinatorial Peptiode Libraries and Their Application in Decoding Biological Interactions
  Employment: Attending Medical School

• Thompson, Mark - Ph.D., WI91
  Advisor:  Dr. Heinz Floss
  Dissertation Title: Studies on the formation of 3,6- and 2,6-dideoxyhexoses.

• Tian, Gaochao - Ph.D., AU88
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title: Mutagenic, stereochemical, and kinetic analyses of the structure and function of adenylate kinase.

• Tippin, Douglas - M.D./Ph.D., SU95
  Advisor:  Dr. Muttaiya Sundaralingam
  Dissertation/Thesis Title: Crystallographic investigation of A-DNA conformations: the effect of hydration, methylation and spermine binding.
  Employment: Partner, Littleton Radiation Oncology, Littleton, CO
  
  
• Wei, Yaoming - Ph.D., SU99
  Advisor:  Dr. Dehua Pei
  Dissertation/Thesis Title:  Peptide Deformylase:  Characterization and Antibacterial
  Drug Design
  Employment: Post-doc w. Dr. Perry Frey, Institute for Enzyme Research,Madison, Wisconsin

• Woodman, Robert - Ph.D., SP91
  Advisor:  Dr. Heinz Floss
  Dissertation/Thesis Title: Molecular and biochemical studies on thiopeptide antibiotic biosynthesis.

• Wu, Jiejun - Ph.D., SU89
  Advisor:  Dr. Alan Marshall
  Dissertation/Thesis Title: Investigation of wheat germ 5S ribosomal RNA common arm fragment solution structures by high resolution nuclear magnetic resonance.

• Xu, Rong - M.S., AU 02
  Advisor: Dr. Ross Dalbey
  Thesis: The Interaction of Escherichia Coli ATPase Subunit A with YidC During Membrane Insertion

• Yan, Honggao - Ph.D., SP91
  AdvisorL  Dr. Ming-Daw Tsai
  Dissertation/Thesis Title: Mechanism of adenylate kinase: a site-directed mutagenesis and nuclear magnetic resonance study.
  Employment: Assistant Professor, Dept of Biochemistry, Michigan State University, East Lansing, MI.

• Yongkiettrakul, Suganya - Ph.D., SP 04
  Advisor:  Dr. Ming Daw Tsai
  Dissertation Title:  Molecular Structure and Specific Interaction of FHA Domains of Saccharomyces Cerevisiae RAD53
  Employment: Research Scientist, The National Science and Technology Development Agency, Biotech Division, Thailand
  
  
  
• Yuan, Jijun - Ph.D., WI 08
  Advisor: Dr. Ross Dalbey
  Dissertation: Membrane Protein Insertaion in Bacteria by the YidC and Sec Pathway
  Employment: Post-Doctoral Researcher, Dept. of Chemistry, Ohio State University

• Zhang, Xiaoyan - M.S., WI94
  Advisor:  Dr. Ming-Daw Tsai
  Thesis Title: Design, synthesis and biological activities of 4-substituted imidazoles as (alpha) 2-adrenoceptor agonists.
  Employment:  Bristol-Myers, Wallingford, CT

• Zhou, Bin-bin - M.S., SU89
  Advisor:  Dr. Ming-Daw Tsai
  Thesis Title: The study of adenylate kinase substrate binding sites by site-directed mutagenesis.
  Employment:  Postdoc, Harvard Medical School

• Zhu, Hongxin - Ph.D., AU95
  Advisor:  Dr. Ming-Daw Tsai
  Dissertation Title: Structure-function studies of bovine pancreatic phospholipase A2: the roles of N-terminal residues in the interfacial activation and the roles of disulfide bonds in the structure, stability, and catalytic function cloning, expression, purification, and functional studies of a potential human HIV-1 repressor gene.
  Employment: Postdoc, Boston University (lab of Charles Cantor)

• Zhu, Jinge Grace - Ph.D., SP 05
  Advisor: Dr. Dehua Pei
  Dissertation: Characterization of s-ribosylhomoeysteinase (LuxS)
  Employment: Post-Doctoral Fellow, University of Wisconsin