Ohio State Biochemistry Program

Brief Faculty Research Descriptions

Faculty Personal Information	Key Words	Brief Research Description
Agarwal, Gunjan Biomedical Engineering - agarwal.60@osu.edu	Bioengineering Cell Biology Lipids Macromolecular Interactions Membrane Proteins Molecular Biophysics Molecular Biology Structural Biology	Atomic Force Microscopy (AFM) and light microscopy for biomedical imaging
Alfonzo, Juan D. Microbiology - alfonzo.1@osu.edu	Cell Biology Gene Regulation Macromolecular Interactions Membrane Proteins Membrane Transport Molecular Biology Molecular Genetics RNA	Editing and Modification of tRNA: Roles in Mitochondrial Biogenesis and Disease
Anderson, Clark A. * Internal Medicine - anderson.48@osu.edu		Dr. Anderson is interested in how IgG antibodies work; specifically, how they mediate inflammatory and protective effects, how they are degraded, and how they are transported across the fetus from maternal to fetal circulation
Armstrong, Gregory A. Plant Cellular and Molecular Biology - armstrong.275@osu.edu		Light regulation of plant development, plastid differentiation and pigment biosynthesis; mechanisms of plant protection against photooxidative damage
Artsimovitch, Irina Microbiology - artsimovitch.1@osu.edu	Chromosomes & Chromatin Gene Regulation Macromolecular Interactions Molecular Biology Molecular Genetics Protein Folding RNA Structural Biology Transcription	Molecular mechanisms of transcription elongation, elongation control of virulence genes in proteobacteria
Askwith, Candice Neuroscience- askwith.1@osu.edu	Human Disease Macromolecular Interactions Membrane Proteins Molecular Biophysics Molecular Biology Molecular Genetics Signal Transduction Structural Biology	Ion channels in synaptic plasticity and sensory transduction: Acid-sensing ion channel (ASIC) function, structure, and role in synaptic physiology.
Bell, Charles E. Molecular and Cellular Biochemistry - bell.489@osu.edu	DNA Repair Recombination Structural Biology	Research in the Bell Lab is focused on the structural biology of homologous recombination, an important mechanism in all cells for repairing double- stranded DNA breaks.
Bisaro, David M. Molecular Genetics - bisaro.1@osu.edu		Molecular biology of geminiviruses; including regulation of viral DNA replication and gene expression, and mechanisms of viral pathogenesis
Bong, Dennis Chemistry - bong.6@osu.edu		Exploration of molecular recognition-guided membrane fusion mechanisms, peptide beta strand recognition and formation of biomimetic nanoscale lattices.
Boris-Lawrie, Kathleen Veterinary Biosciences - boris-lawrie.1@osu.edu	Bioinformatics Cancer Cell Biology Gene Regulation Human Disease Molecular Biophysics Molecular Biology Molecular Genetics Molecular Medicine RNA Structural Biology Translation Virology	Genetic, biochemical and genomic approaches are being used to understand post-transcriptional control mechanisms used by retroviruses and their host cells to modulate viral infection and control cellular growth.
Breitenberger, Caroline A Biochemistry - breitenberger.1@osu.edu		Structure and function of genes encoding protein synthesis factors.
Brooks, Charles L. Veterinary Biosciences - brooks.8@osu.edu	Membrane Proteins Macromolecular Interactions Molecular Biophysics Post-translational modification Protein Engineering	Protein chemistry and endocrinology.
Brueggemeier, Robert W. Medicinal Chemistry and Pharmacognosy - brueggemeier.1@osu.edu		The role of steroids in the growth of breast cancer and in the development of drugs that interfere with hormone action or hormone biosynthesis, aromatase inhibitors
Burghes, Arthur H.M. Molecular and Cellular Biochemistry - burghes.1@osu.edu		The main focus of the laboratory is the molecular understanding of genetic neuromuscular disorders. In particular, the laboratory focuses on unraveling the molecular biology of Spinal Muscular Atrophy (SMA).
Chalmers, Jeffrey J. Chemical Engineering - chalmers.1@osu.edu	Bioengineering Bioinformatics Cancer	My research is in the area of bioengineering. I have current interest/projects in the broad areas of cell culture, ranging from the study of human stem and cancer cells to industrially relevant cells.
Chan, Michael K. Biochemistry/Chemistry - chan.136@osu.edu	Structural Biology Membrane Proteins Membrane Transport Chemical Biology Bioinformatics	The Chan laboratory focuses on problems at the interface of chemistry and biology requiring the use of techniques spanning a wide range of disciplines including macromolecular crystallography, organic and inorganic synthesis, molecular cloning, protein overexpression and purification, and spectroscopy.
Chang, Long-Sheng Columbus Children’s Research Institute and Pediatrics - lchang@chi.osu.edu	Cancer Cell Biology Development Gene Regulation Human Disease Molecular Biology Molecular Genetics Molecular Medicine Signal Transduction	Regulation and functions of the retinoblastoma-family suppressor genes; neural specific serotonin 5-HT2C receptor expression; DNA polymerase and DNA replication; erythrocyte protein 4.2 expression; transgenic mice for animal models
Chang, Tien-Hsien Molecular Genetics - chang.108@osu.edu	Gene Regulation Molecular Biology Molecular Genetics RNA Systems Biology Transcription Translation	Yeast RNA helicases involved in nuclear pre-mRNA splicing, mRNA export & translation
Chen, Ching-Shih Medicinal Chemistry and Pharmacognosy - chen.844@osu.edu	Cancer Chemical Biology Human Disease Molecular Medicine Post-translational Modification Protein Degradation Signal Transduction	Dr. Chen¹s research focuses on exploring signaling pathways that govern cancer cell survival as targets for drug discovery and design.
Chiu, Ing-Ming Internal Medicine - chiu.1@osu.edu	Cancer Cell Biology Chromosomes & Chromatin Development Epigenetics Gene Regulation Human Disease Molecular Medicine Transcription	Controlling mechanism of gene expression of fibroblast growth factor 1 in cancer and in atherosclerosis.
Coleman, Robert Chemistry - coleman@chemistry.ohio-state.edu	Cancer Chemical Biology Molecular Medicine	The Coleman group is interested in the study of naturally occurring antitumor agents. A current focus is the antitumor agents azinomycins A and B, which have biological activity in vitro and in vivo in experimental tumor systems, and whichcovalently cross-link duplex DNA.
Cowan, James A. Chemistry - cowan.2@osu.edu	Chemical Biology Enzymology Glycobiology Macromolecular Interactions Membrane Proteins Membrane Transport Molecular Biophysics Molecular Biology Molecular Genetics Molecular Medicine Protein Engineering RNA Structural Biology	Our research seeks to understand the critical roles of metal ions in biology with a focus on some of the most important problems in bioinorganic chemistry. Of particular interest is the chemistry of cellular iron, the proteins that transport, store, and use iron in redox and catalytic roles.
Curley, Robert W. Jr. Medicinal Chemistry and Pharmacognosy - curley.1@osu.edu	Cancer Chemical Biology Structural Biology Metabolism	Our primary research interests lie in the area of the medicinal chemistry and biochemistry of important vitamin A metabolites with potential to function as cancer chemopreventive agents.
Dalbey, Ross E. Chemistry - dalbey@chemistry.ohio-state.edu	Cell Biology Enzymology Membrane Proteins Membrane Transport Molecular Biophysics Molecular Biology Molecular Genetics Protein Degradation Protein Engineering Protein Folding Structural Biology	Our lab's central interest is the determination of how proteins are transported and inserted into membranes to obtain their membrane topology. We are employing biochemical approaches to begin purifying proteins that catalyze the membrane assembly of proteins.
Daniels, Charles J. Microbiology - daniels.7@osu.edu		Molecular Biology of the archaea: archaeal SNO-RNAs.
Davis, Jonathan Physiology & Cell Biology davis.812@osu.edu	Enzymology Human Disease Macromolecular Interactions Molecular Biophysics Muscle Biochemistry Muscle Physiology Protein Engineering Signal Transduction	Elucidate the biochemical and physiological mechanisms that determine the kinetics of cardiac and skeletal muscle contraction and relaxation in health and disease through the engineering of proteins
Dean, Donald H. Biochemistry - dean.10@osu.edu		Protein engineering and biophysical analysis of insecticidal toxins is the major research interest in my laboratory.
DeWille, James Veterinary Biosciences - dewille.1@osu.edu		Molecular Mechanisms of Growth Regulation.
Fisk, Harold Molecular Genetics - fisk.13@osu.edu	Cancer Cell Biology Molecular Biology Molecular Genetics	Centrosome duplication, cell cycle regulation, mitotic spindle assembly.
Foster, Mark P. Biochemistry - foster.281@osu.edu	DNA Repair Enzymology Gene Regulation Macromolecular Interactions Molecular Biophysics Molecular Biology Protein Folding Recombination RNA Signal Transduction Structural Biology Transcription Translation	Protein and nucleic acid structure and dynamics, molecular recognition, signal transduction, enzyme catalysis, computational methods, NMR methodology.
Fredrick, Kurt Microbiology - fredrick.5@osu.edu	Translation RNA Gene Regulation	Understanding the relationship between ribosome structure and function.
Godbout, Jonathan MVIMG - godbout.2@osu.edu	Human Disease Molecular Medicine Signal Transduction Immunology Neuroscience	We are interested in delineating how elevated and prolonged exposure to inflammatory cytokines in the aged brain impairs neurotransmitter and neurotrophic signaling pathways to promote these neurobehavioral deficits.
Gopalan, Venkat Biochemistry - gopalan.5@osu.edu	Gene Regulation Macromolecular Interactions Membrane Proteins Molecular Biology Plant Biochemistry RNA Translation	Structure and function of ribonuclease P, an enzyme which has both RNA and protein moieties. A major goal of our work is to understand how the protein cofactor facilitates RNA catalysis
Green, Patrick L. Veterinary Biosciences - green.466@osu.edu		Molecular Pathogenesis of Human T-cell Leukemia Virus (HTLV) Molecular Biology of Retrovirus Replication T-cell Activation/Transformation
Grotewold, Erich Plant Cellular and Molecular Biology - grotewold.1@osu.edu	Computational Biology Gene Regulation Plant Biochemistry Development	Regulation of gene expression; function and evolution of Myb proteins; plant metabolic engineering; regulatory networks; computational biology.
Gu, Howard H Pharmacology - gu.37@osu.edu	Human Disease Membrane Proteins Membrane Transport Molecular Biology Molecular Genetics Molecular Medicine	Mechanism of drug addition using tools from molecular biology to cell culture, genetically modified animal models, and animal behaviors.
Gunn, John S. MVIMG and Internal Medicine - gunn.43@osu.edu	Cell Biology Chromosomes & Chromatin Gene Regulation Glycobiology Human Disease Lipids Macromolecular Interactions Membrane Proteins Molecular Biology Molecular Genetics Molecular Medicine Post-translationsl Modification Signal Transduction Structural Biology Transcription	Dr. Gunn's laboratory is primarily interested in the molecular mechanisms used by Salmonella spp. to survive harsh conditions it encounters within the human host.
Hai, Tsonwin Molecular and Cellular Biochemistry - hai.2@osu.edu	Cancer Cell Biology Gene Regulation Human Disease Molecular Biology Molecular Genetics Molecular Medicine Post-translational Modification Signal Transduction Transcription	Cancer and many diseases are manifestations of over expression or under expression of a gene or a group of genes. Although there are many regulatory steps in the process of gene expression, many lines of evidence indicate that transcriptional control is the focal point of regulation. My laboratory is investigating the transcriptional regulation in eukaryotes.
Hamel, Patrice Plant Cellular and Molecular Biology - hamel.16@osu.edu		Maturation of c-type cytochromes in organelles, redox components and heme delivery systems in yeast mitochondria and green alga plastids.
Harrison, Earl Human Nutrition harrison.304@osu.edu	Cell Biology Enzymology Human Disease Lipids Membrane Transport Metabolism	Our laboratory studies the basic mechanisms involved in the intestinal absorption, transport, and metabolism of dietary vitamin A and carotenoids using cell culture and animal models and investigations in human subjects
Henkin, Tina Microbiology - henkin.3@osu.edu	gene regulation molecular biology molecular genetics RNA transcription translation	Transcription termination control in Gram-positive bacteria; RNA structure/function.
Herman, Paul Molecular Genetics - herman.81@osu.edu	Cancer Cell Biology Gene Regulation Macromolecular Interactions Membrane Transport Metabolism Post-translational Modification Protein Phosphorylation Signal Transduction Transcription Translation	Research in my lab is focused on developing a better understanding of the mechanisms controlling cell growth and proliferation in eukaryotic cells. Our long term goals are to identify novel proteins important for proliferative control and to investigate whether these proteins might be useful targets for cancer therapy.
Hopper, James Biochemistry - hopper.65@osu.edu	Gene Regulation Transcription Molecular Biology Molecular Genetics	Many disease states are known to be due to defective gene switches. A gene switch that is under investigation in my laboratory is the genetically well-characterized multi-component gene switch that regulates 10 genes (GAL genes) that specify galactose utilization functions in the yeast, S. cerevisiae.
Ibba, Michael Microbiology - ibba.1@osu.edu	Chemical Biology Enzymology Macromolecular Interactions Molecular Biophysics Molecular Biology Molecular Genetics RNA Translation	Protein synthesis in bacteria and archaea. Aminoacyl-tRNA synthetase cell biology and biochemistry.
Jackman, Jane Biochemistry jackman.14@osu.edu	Enzymology RNA RNA processing and modification	The Jackman laboratory utilizes the principles and techniques of mechanistic enzymology and enzyme kinetics to elucidate the molecular mechanisms of tRNA processing enzymes.
Jacob, Samson, T. Molecular and Cellular Biochemistry - jacob.42@osu.edu	Cancer Chromosomes & Chromatin Epigenetics Gene Regulation Human Disease Molecular Genetics Molecular Medicine RNA Transcription	transcriptional regulation in normal and cancel cells, DNA methylation and gene silencing in disease processes.
Jaroniec, Christopher Chemistry jaroniec@chemistry.ohio-state.edu	Macromolecular Interactions Membrane Proteins Molecular Biophysics Protein Folding Structural Biology	Biophysical Chemistry, Nuclear Magnetic Resonance Spectroscopy, Protein Structure, Folding and Misfolding
Jhiang, Sissy M. Physiology & Cell Biology - jhiang.1@osu.edu	Cancer Cell Biology Chemical Biology Gene Regulation Human Disease Macromolecular Interactions Membrane Proteins Membrane Transport Molecular Biology Molecular Medicine Post-translational Modification Protein Degradation Protein Engineering Signal Transduction	Tyrosine kinase signal transduction, transgenic mouse animal model for human diseases, gene regulation and functional analysis of sodium/iodide symporter, gene transfer of sodium/iodide symporter for radioiodide therapy in human cancers
Kaspar, Brian Columbus Children's Research Institute - kasparB@ccri.net	Bioengineering Cell Biology Development Epigenetics Human Disease Molecular Medicine	Dr. Kaspar's research is concentrated on the developing and adult central nervous system with emphasis on neurodegenerative and neurological disorders that occur throughout the lifespan of all mammals.
Kaumaya, Pravin T.P. Obstetrics & Gynecology - kaumaya.1@osu.edu		Peptide and protein design; protein antigenic and immunogenic determinant; protein folding and synthetic vaccines; cancer vaccines.
Krzycki, Joseph Microbiology - krzycki.1@osu.edu	Chemical Biology Enzymology Metabolism Molecular Biology Molecular Genetics RNA Translation	Biochemistry and molecular biology of methanogenic Archaea. Pyrrolysine, the "22nd amino acid".
Kuret, Jeff Molecular and Cellular Biochemistry - kuret.3@osu.edu	Chemical biology Human disease Enzymology Macromolecular interactions Molecular biology Molecular medicine Post-translational modification	This laboratory investigates pathogenic pathways that lead to the appearance of granulovacuolar and neurofibrillary lesions found in Alzheimer's Disease and other dementias.
Lairmore, Michael D. Chairman, Veterinary Biosciences - lairmore.1@osu.edu	Cancer Cell Biology DNA Repair Human Disease Molecular Biology Post-translational Modification Signal Transduction Transcription	Molecular Pathogenesis of Human T-Lymphotropic Virus (HTLV) Infection Transcriptional Regulation of HTLV Evaluation of Immunodominant Epitopes of HTLV
Lee, Beth S. Physiology - lee.2076@osu.edu	Cell Biology Cytoskeleton Gene Regulation Molecular Biology RNA Transcription Translation	Gene regulation, RNA and protein targeting, and membrane dynamics with a current project concerning the regulation and targeting of the vacuolar H+-ATPase (V-ATPase, the membrane-bound enzyme that acidifies endosomal compartment of eukaryotic cells). A second project concerns the regulation of motility and cell shape by actin-binding proteins in osteoclasts.
Lee, Stephen Molecular and Cellular Biochemistry - lee.1996@osu.edu		Dr. Lee's interest is in molecular therapeutic devices (for cancer and cardiovascular disease) and technologies that support their realization.
Leone, Gustavo MVIMG leone.24@osu.edu	Cancer Cell Biology Development Gene Regulation Molecular Biology Molecular Genetics Signal Transduction Transcription	- Dr. Leone's lab is currently studying the role of the Ras pathway in coordinating cell growth and cell death signals elicited by the E2F and Myc transcription programs
Li, Chenglong Pharmacy - cli@dendrite.pharmacy.ohio-state.edu	Bioinformatics Cancer Chromosomes & Chromatin Computational Biology Drug Design and Discovery Enzymology Epigenetics Human Disease Macromolecular Interactions Membrane Proteins Metabolism Molecular Biophysics Molecular Biology Molecular Simulation Post-translational Modification Protein Degradation Protein Engineering Protein Folding Signal Transduction Structural Biology Systems Biology	My long-standing scientific interest is to understand the structure and dynamics of matter at the atomic/molecular level (“the jigglings and wigglings of atoms” from the wonderful Feynman Lectures on Physics), and their relationship to the functions and properties of our physical and biological macro-world (the spatial-temporal collective behavior).
Lin, C. Glenn Neuroscience - lin.492@osu.edu	Human Disease Molecular Biology Molecular Medicine RNA	Molecular mechanisms underlying neurodegenerative diseases - RNA oxidation, glutamate transporter alterations; molecular biology and biochemistry of glutamate transporters
Lin, Jiayuh Columbus Children’s Research Institute and Pediatrics - linj@pediatrics.ohio-state.edu	Cancer Cell Biology Molecular Biology Signal Transduction Transcription	Regulation of signal transduction and tyrosine kinase pathways in human cancers and molecular target therapy of cancers.
Ma, Jiyan Molecular and Cellular Biochemistry - ma.131@osu.edu		We are studying the Transmissible Spongiform Encephalopathies (TSEs), also known as prion disease. This is a group of unique neurodegenerative disorders that can be manifested as sporadic, dominantly inheritable, or infectious diseases.
Magliery, Thomas J. Chemistry/Biochemistry magliery@chemistry.ohio-state.edu	Bioinformatics Chemical Biology Macromolecular Interactions Molecular Biophysics, Protein Engineering Protein Folding	Combinatorial and statistical approaches to protein stability, structure and function; unnatural amino acid mutagenesis
Marketon, Jeanette Internal Medicine - marketon.1@osu.edu	Nucler Hormone Receptors Gene Regulation Signal Transduction Steroid Receptors	Mechanisms of modulation of nuclear hormone receptor signaling by environmental agents and disease
Marsh, Clay B. Pulmonary & Critical Care Medicine - marsh.2@osu.edu		Investigation of biochemical pathways in human blood monocytes that mediate survival and activation of the cells; studies related to the effects of treatment of monocytes with the growth factor macrophage colony-stimulating factor and intracellular signaling pathways that are affected by stimulation of human monocytes and macrophages with this growth factor.
Martin, Paul T. Columbus Children’s Research Institute and Pediatrics - MartinPT@pediatrics.ohio-state.edu	Cell Biology Development Gene Regulation Glycobiology Human Disease Membrane Proteins Molecular Medicine	Dr. Martin's research is focused on the role of glycoslation in synapse formations and muscular dystrophy.
Means, Gary E. Biochemistry - means.1@osu.edu		Protein chemistry, modification, structure-function relationships, enzyme immobilization, multienzyme reactors, effects of nitric oxide, nitrovasodilators and other nitrosating agents on proteins.
Mehta, Kemal Molecular and Cellular Biochemistry - mehta.80@osu.edu	Signal Transduction	My laboratory is interested in understanding the signaling cascades and the mechanisms regulating transcription of lipoprotein receptors involved in the pathogenesis of cardiovascular diseases.
Montanaro, Federica Columbus Children’s Research Institute and Pediatrics - montanaf@pediatrics.ohio-state.edu	Cell Biology Human Disease Molecular Biology Stem Cells Development	My research focus is muscular dystrophy with a particular emphasis on Duchenne muscular dystrophy. We study the molecular mechanisms by which disruption of the dystrophin-associated complex leads to muscle cell death and we identify populations of stem cells that can be used to develop a long term cell-based treatment for muscular dystrophy.
Musier-Forsyth, Karin Chemistry and Biochemistry musier-forsyth.1@osu.edu	Chemical Biology Enzymology Human Disease Macromolecular Interactions Molecular Biophysics Molecular Biology	Substrate Recognition by Aminoacyl-tRNA Synthetases, RNA-Protein Interactions in HIV
Oberdick, John D. Neuroscience - oberdick.1@osu.edu	Development Gene Regulation Human Disease Transription	Gene expression in the brain; mRNA transport; motor learning and memory
Osmani, Stephen Molecular Genetics -	Cell Biology Cell Cycle Regulation Nuclear Transport Nuclear Structure Nucleolus Mitosis Protein phosphorylation	Elucidating how the cell cycle is regulated utilizing the model filamentous fungus Aspergillus nidulans
Ostrowski, Michael C. Molecular Genetics - ostrowski.4@osu.edu	Cancer Development Epigenetics Gene Regulation Molecular Biology Molecular Genetics Post-translational Modification Signal Transduction Systems Biology Transcription	The Ostrowski lab has a long-standing interest in understanding how signaling pathways elicit selective, persistent changes in gene transcription in mammalian cells.
Ottesen, Jennifer Biochemistry - ottesen.1@osu.edu	Chemical Biology Molecular Biophysics Macromolecular Interactions Chromosomes & Chromatin	Research in the Ottesen laboratory utilizes peptide and protein chemistry to address biological problems. The Ottesen group is developing improved techniques for solid phase chemical ligation, which allows the rapid recombination of peptide elements into larger macromolecules.
Palmer, Andre Chemical and Biomolecular Engineering palmer.351@osu.edu	Bioengineering	research interests in Hemoglobin-based oxygen carriers for transfusion and cell culture applications, Self-assembled therapeutic delivery systems, Protein and tissue engineering.
Park, Hay-Oak Molecular Genetics - park.294@osu.edu	Cancer Cell Biology Enzymology Gene Regulation Human Disease Macromolecular Interactions Membrane Proteins Membrane Transport Molecular Biology Molecular Genetics Post-translational Modification Protein Degradation Signal Transduction	Our lab is interested in understanding the molecular mechanisms by which GTPases control various cellular processes in response to intra- and extra-cellular signals.
Parris, Deborah MVIMG and Molecular Genetics - parris.1@osu.edu	DNA Replication DNA Repair Enzymology Human Disease Macromolecular InteractionsMolecular Biology Molecular Medicine Recombination RNA Virology	Herpes simplex virus (HSV) is one of the most complex of the animal viruses encoding more than 80 different genes. Despite its complexity, it is the easiest member of the herpes virus family with which to work and has proven to be a good model system to study functions related to viral replication.
Parthun, Mark R. Molecular and Cellular Biochemistry - parthun.1@osu.edu	Chromosomes & Chromatin DNA Repair Epigenetics Gene Regulation Post-translational Modification Transcription	Chromatin structure
Paulaitis, Michael Chemical Engineering paulaitis.1@osu.edu	Computational Biology Macromolecular Interactions Molecular Biophysics Nanobiotechnology	Molecular simulations and modeling of weak protein-protein interactions; the role of hydration in biological organization and self-assembly phenomena; multiscale modeling of biological interactions.
Pei, Dehua Chemistry - pei.3@osu.edu	Bioinformatics Chemical Biology Enzymology Macromolecular Interactions Signal Transduction Systems Biology	Enzyme mechanisms, protein-protein interactions, bacterial quorum sensing, eukaryotic cell signaling
Periasamy, Muthu Physiology - periasamy.1@osu.edu		Genetic engineering of the heart, genes that determine cardiac structure and function, molecular basis of heart failure and gene
Pfeiffer, Douglas R. Molecular and Cellular Biochemistry - pfeiffer.17@osu.edu		Our research programs are in the areas of bioenergetics, transport, and membrane biophysics. A general diffusion pore of the inner mitochondrial membrane is under investigation, as a structure that is central to mechanisms of cell death under conditions which promote necrosis and apoptosis.
Poirier, Michael G. Physics - mpoirier@mps.ohio-state.edu	Chromosomes & Chromatin Post-translational Modification Transcription Molecular Biophysics Single Molecule	My lab uses biophysical and biochemical approaches to understand chromatin structure and dynamics and how it is modulated to regulate gene expression.
Rafael-Fortney, Jill A. Molecular and Cellular Biochemistry - rafael.1@osu.edu	Molecular Genetics Cell Biology Human Disease Animal Models	The long-term goals of my laboratory are to delineate the pathogenic mechanisms of neuromuscular diseases in order to design rational approaches for treatments. Our lab focuses on two different basic science projects: 1) The roles of the PDZ domain proteins Dlg and CASK at the mammalian neuromuscular junction and in neuromuscular disease. 2) Delineation of the pathways leading to cardiomyopathy and skeletal muscle fiber-type abnormalities in a mouse model of Duchenne muscular dystrophy (DMD).
Ringel, Matthew Internal Medicine - Matthew.Ringel@osumc.edu	Cancer Cell Biology Molecular Medicine Signal Transduction	Dr. Ringel’s research is aimed at understanding the molecular mechanisms involved in thyroid cancer invasion and metastasis. He also has an active interest in new drug testing for thyroid cancer therapy.
Rotter, Andrej Pharmacology (College of Medicine) - rotter.1@osu.edu	Bioinformatics	Bioinformatics and computational biology approaches to the analysis of genes coding for neural signal transduction molecules.
Sayre, Richard T. Plant Cellular and Molecular Biology - sayre.2@osu.edu	Bioengineering Membrane Proteins Membrane Transport Metabolism Molecular Biophysics Plant Biochemistry Protein Engineering	There are three major research programs in our lab including; 1) nutrient bio-fortification and metabolic engineering of cyanogenesis in the tropical root crop cassava, 2) molecular studies on primary photochemical processes in photosystem II complexes of chloroplasts, and 3) biotechnological applications of microalgae
Schoenberg, Daniel R. Molecular and Cellular Biochemistry - schoenberg.3@osu.edu	Cancer Cell Biology Gene Regulation Molecular Biology RNA Signal Transduction Translation	The overall theme of research in the Schoenberg lab is how extracellular stimuli alter gene expression through changes in the processing and metabolism of mRNAs.
Sif, Saïd Molecular and Cellular Biochemistry - sif.1@osu.edu		My laboratory is interested in studying transcription factor interactions with DNA in a chromatin context, and also in examining the effects of the Brg1 and hBrm-based human SWI/SNF chromatin remodeling complexes on nucleosomal DNA. My laboratory is also interested in studying the mechanisms that regulate the activity of the Brg1 and hBrm complexes, and understanding how phosphorylation affects their activity and interaction with transcription factors during different stages of cell growth and development.
Snapka, Robert M. Radiology - snapka.1@osu.edu	Cancer Cell Biology Chemical Biology Chromosomes & Chromatin DNA Replication DNA Repair Macromolecular Interactions Molecular Medicine Protein Degradation	Multiple approaches to understanding mechanisms of anti-cancer drugs, particularly those targeting DNA replication; molecular-level cell- killing mechanisms; drug resistance, gene amplification, drug discovery
Somers, David Plant Cellular and Molecular Biology- somers.24@osu.edu	Circadian Biology Cell Biology Development Molecular Biology Molecular Genetics Plant Biochemistry Post-translational Modification Protein Degradation Protein Folding Signal Transduction	My lab studies two aspects of the circadian clock in plants. The first is to understand the components and processes involved in the transduction of the daily environmental light/dark cycle to the central oscillator of the clock. My second interest is to understand the molecular nature of the central clock oscillator and how it is coupled to the light input pathway.
Strauch, Arthur R. Physiology - strauch.1@osu.edu	Cell Biology Chromosomes & Chromatin Development Gene Regulation Human Disease Macromolecular Interactions Molecular Biology Molecular Genetics Molecular Medicine Signal Transduction Transcription	Cardiovascular cellular and molecular biology, actin gene expression, muscle development, cardiac transplantation
Sun, Duxin Pharmaceutics - sun.176@osu.edu	Molecular Medicine Chemical Biology Human Disease Macromolecular Interactions Membrane Transport Molecular Biology Cancer	(A) An integrated system for both tumor imaging and targeted drug therapy for colorectal cancer, (B) A novel Hsp90 inhibitor to disrupt Hsp90-Cdc37 interaction for pancreatic cancer therapy, (C) Chemical biology and micro RNA to overcome multidrug resistance in leukemia, (D) transporters in cancer imaging, pharmacokinetics/pharmacodynamics (PK/PD) modeling.
Suo, Zucai Biochemistry - suo.3@osu.edu	Cancer DNA Replication DNA Repair Enzymology Structural Biology	The research in my laboratory has three major directions: one is to elucidate kinetic mechanisms of enzymes involved in DNA/RNA replication, repair, and lesion bypass; the second is to understand Hepatitis C (HCV) replication and regulation of innate immunity; the third is to develop antiviral and anti-cancer molecules based on rational drug design.
Swenson, Richard P. Chairman, Biochemistry - swenson.1@osu.edu	Enzymology Macromolecular Interactions Protein Engineering Molecular Biophysics Structural Biology	our research is focused primarily on the study of a family of proteins that use derivatives of riboflavin (vitamin B2) as essential cofactors or coenzymes for their biological activity. Our emphasis is the investigation of the structure of the protein, its influence on the chemical and oxidation-reduction and other chemical properties of the bound flavin cofactor, and the role of the cofactor in catalysis and/or electron transfer.
Tabita, F. Robert Ohio Eminent Scholar, Microbiology - tabita.1@osu.edu	Bioengineering Chemical Biology Enzymology Gene Regulation Metabolism Molecular Biology Protein Engineering Structural Biology Transcription	Biochemistry, molecular biology, molecular ecology, archaea. My laboratory is concerned with the molecular regulation, biochemistry,and enzymology of carbon dioxide assimilation.
Tridandapani, Susheela Internal Medicine - tridandapani.2@osu.edu		Regulation of Signal Transduction Processes Involved in Immune-Complex (IC) Clearance and the Associated Inflammation.
Turro, Claudia Chemistry - turro@chemistry.ohio-state.edu		Inorganic Photochemistry, Excited State Processes, DNA Interactions The Turro group is interested in understanding and utilizing reactions of metal complexes that can be initiated with light.
Vaessin, Harald Molecular Genetics - vaessin.1@osu.edu		Research in my laboratory focuses on the question how cell proliferation and terminal differentiation is regulated during neurogenesis (and later in adult life).
Vaghy, Pal L. Molecular and Cellular Biochemistry - vaghy.1@osu.edu		Our general interest is to identify and characterize autocrine and paracrine signaling mechanisms in skeletal muscle.
Verma, Desh P.S. Molecular Genetics - verma.1@osu.edu		Mechanisms of Cell Plate Formation and Stress Regulation in Plant Cells
Walsh, Scott Molecular and Cellular Biochemistry - walsh.220@osu.edu	Bioengineering Bioinformatics Cancer Chemical Biology Glycobiology Human Disease Lipids Macromolecular Interactions Membrane Proteins Molecular Biophysics Molecular Biology Post-translational Modification Protein Degradation Protein Engineering Protein Folding Signal Transduction Structural Biology	Our research focuses on understanding the roles of structure, dynamics and energetics in molecular recognition among different classes of cytokines and their receptors.
Wang, George Ohio Eminent Scholar, Biochemistry - pgwang@chemistry.ohio-state.edu	Chemical Biology Glycobiology Macromolecular Interactions	The focus of Professor Wang’s research is on synthetic organic chemistry, bioorganic chemistry and biochemistry. Combining modern organic synthesis with the latest discoveries in biology, we have been undertaking research programs on natural product synthesis, on reactive nitrogen species, on synthetic methodology development, and on biosynthetic pathway engineering.
Wani, Altaf Radiology - wani.2@osu.edu	Cancer Cell Biology Chromosomes & Chromatin DNA Repair Enzymology Epigenetics Gene Regulation Human Disease Macromolecular Interactions Membrane Proteins Molecular Biology Molecular Genetics Molecular Medicine Post-translational ModificationProtein DegradationSignal TransductionTranscription	Molecular carcinogenesis-analysis, fine mapping and cellular processing of specific genotoxic base lesions, mutagenesis, apoptosis and other DNA damage responses
WU, Justin Biochemistry - wu.473@osu.edu	Gene Regulation Macromolecular Interactions Membrane Proteins Protein Folding Signal Transduction Structural Biology	Characterization of macromolecules, including protein-protein, protein-nucleic acid complexes, membrane proteins and glycosylated proteins by means of modern NMR spectroscopy; dynamic studies of macromolecules for understanding their functional mechanism; drug development based on structural studies of drug-target complexes
Wu, Lai-Chu Molecular and Cellular Biochemistry - wu.39@osu.edu	Cancer Cell Biology Development Epigenetics Gene Regulation Molecular Biology Molecular Genetics Protein Degradation Signal Transduction Transcription	Mammalian immunogenetics, somatic V(D)J recombination, gene expression and regulation, cancer
Xia, Yong Internal Medicine - xia.34@osu.edu	Bioengineering Bioinformatics Cell Biology Chemical Biology Enzymology Epigenetics Gene Regulation Human Disease Lipids Macromolecular Interactions Membrane Proteins Metabolism Molecular Biophysics Molecular Biology Molecular Medicine Post-translational Modifiation Protein Degradation Protein Engineering Protein Folding Recombination RNA Signal Transduction Systems Biology Transcription Translation	Molecular cardiovascular biology, biochemistry, nitric oxide biology, oxidative stress, signal transduction, free radical biology. The overall research interest of the Xia laboratory is in the molecular mechanisms of cardiovascular regulation and diseases.
Yang, Shang-Tian Chemical Engineering - yang.15@osu.edu	Bioengineering Bioinformatics Cancer Cell Biology Metabolism Molecular Biology Molecular Genetics Recombination Systems Biology	Our current research program covers two important areas in bioprocessing and bioengineering. The first one is animal cell culture and tissue engineering; the second one is bioprocessing for value-added products.
Yoon, Sung Ok Molecular and Cellular Biochemistry - yoon.84@osu.edu	Bioinformatics Cell Biology Development Gene Regulation Human Disease Membrane Proteins Molecular Biology Molecular Genetics Post-translational Modification Protein Degradation Signal Transduction	Intracellular signaling mechanisms involved in cell survival and apoptosis. Receptor tyrosine kinase signaling, cytokine receptor signaling, GTPases. The research combines the in vitro biochemical analyses and in vivo animal models using recombinant adenoviruses and transgenic animal approaches
Young, Anthony Pharmacology - young.38@osu.edu		Gene expression during retinal development and in response to glucucorticoid hormones
Zhong, Dongping Physics - dongping@mps.ohio-state.edu		Understanding the nature of elementary processes in biological systems and relating dynamics and structures to function in real systems level, using state-of-the-art femtosecond lasers and molecular biology methods. The laboratory ultimately will have the capability of time resolution millisecond; biological systems can be prepared and studies at the single molecular level. We are currently focusing on studies of molecular recognition dynamics of several important biological systems.
Zhu, Mike Neuroscience - zhu.55@osu.edu		Molecular mechanism of calcium influx mediated by store-operated plasma membrane calcium and cation channels.

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