MCDB Mentoring Faculty

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Name	Research Interests	Areas of Research
Ainslie, Kristy	Drug delivery and applied immunology	Other
Last Updated: 28-Nov-2012
Alonso, Ana P.	Research focuses on the understanding of plant/crop metabolism to increase the production of valuable compounds. The lab uses a dual approach combining metabolomics and fluxomics studies to unravel the biochemistry involved in storage product accumulation and to identify targets for metabolic engineering.	Plant Molecular Biology Other
Amacher, Sharon L.	Interested in how cells become sequentially determined to more precisely defined fates during vertebrate embryonic development and how this process depends upon cell position and upon interactions among neighboring cells. To address these questions, we use genetics, molecular biology, time-lapse imaging, and embryology to investigate mesodermal patterning, segmentation and muscle development in the zebrafish embryo, a well-established model for human development and disease.	Cancer Biology Cell Biology Developmental Biology Gene Expression RNA Biology
Amer, Amal	Host-pathogen interaction, f ocused on the role of cytosolic NOD-like receptors and their ability to activate inflammatory responses to combat pathogens and the role of caspases in innate immune response to pulmonary pathogens.	Cell Biology Other
Artsimovitch, Irina	Molecular mechanisms of bacterial gene expression and its control by nucleic acid signals, regulatory proteins, and antibiotics.	Gene Expression RNA Biology
Asano, Maki Graduate Studies Committee	We study the molecular mechanisms regulating the cell cycle progression, with focus on the initiation of DNA replication. We use Drosophila as a genetically and molecularly amenable model system.	Cancer Biology Developmental Biology DNA Replication/Repair Gene Expression
Askwith, Candice	The role of acid-sensing ion channels in neuronal signaling.	Molecular Neurobiology
Bartlett, Christopher Graduate Studies Committee	Focus on gene discovery for specific language impairment, autism and related cognitive traits	Other
Basu, Sujit (Heart & Lung Institute) (Pathology)	Angiogenesis and vasculogenesis; tumor microenvironment including cancer stem cells; preclinical cancer chemotherapy; neural immune cross talk in cancer.	Cancer Biology Cell Biology Molecular Medicine Other
Beattie, Christine	Elucidation of the underlying causes of motoneuron dysfunction in motoneuron diseases using zebrafish as a model system.	Developmental Biology Molecular Neurobiology
Benson, Don M., Jr	Research is focused in natural killer cell immunity against multiple myeloma and other B-cell hematologic malignancies. Our work is primarily translational and concentrated in the development of novel immunotherapeutics for B-cell hematologic malignancies including cytokines, antibodies, and immune modulating agents both in a conventional setting and in the context of blood and marrow transplantation.	Cancer Biology Other
Besner, Gail	Use of growth factors in the treatment of intestinal ischemia/reperfusion injury.	Cell Biology Gene Expression
Biesiadecki, Brandon	Understanding the molecular mechanisms of how muscle protein post-translational modifications (phosphorylation, radical modification, degradation, etc) alter heart function	Molecular Medicine
Bisaro,David Program Director, Chair of the Graduate Studies Committee	Geminivirus replication, gene expression, and pathogenesis. The role of small RNA-directed epigenetic silencing in defense against DNA viruses.	Gene Expression Plant Molecular Biology RNA Biology Virology
Boris-Lawrie, Kathleen	Post-transcription control of retroviruses; HIV-1 translation and RNA silencing suppression; Genome-wide analysis of RNA helicase A translation control.	Gene Expression RNA Biology Virology
Brigstock, David	Characterization of connective tissue growth factor: structure-function analysis and role in fibrotic disease	Cancer Biology Cell Biology Developmental Biology Molecular Medicine
Brown, Anthony	The mechanism of slow axonal transport	Cell Biology Molecular Neurobiology Other
Burghes, Arthur Contact Information Only	Genetics of motor neuron disorders and the muscular dystrophies	Molecular Medicine Molecular Neurobiology
Byrd, John	The Byrd laboratory is focused on the 1) study of molecular and immune pharmacology in hematologic malignancies and 2) biology of malignant leukemia B-cell transformation. Our group is involved in identifying new targets for therapeutic exploitation and translating several novel targeted therapies and antibody based treatments from the lab to the clinic.	Cancer Biology Gene Expression Molecular Medicine
Chamberlin, Helen	Understanding the molecular processes underlying organogenesis	Developmental Biology Gene Expression
Chandler, Dawn Member, Graduate Studies Committee	Cancer biology; regulation of pre-mRNA splicing in normal cellular function and disease.	Cancer Biology Molecular Neurobiology RNA Biology
Chang, Long-Sheng	Retinoblastoma-family genes; neurofibromatosis 2 suppressor gene; serotonin 5-HT2C receptor; DNA polymerase d in aging, transgenic mice	Cancer Biology Developmental Biology DNA Replication/Repair Gene Expression Molecular Neurobiology
Chotani, Maqsood	Molecular signaling in vascular smooth muscle cells and cardiac myocytes, the biology of the G protein coupled á2-adrenoceptor subtype C (á2C), and elucidating the role of Ras-related small GTPase Rap1 in the cardiovasculature.	Cell Biology Gene Expression Other
Clark, K. Reed	Molecular medicine, focusing on viral vectors, gene therapy, and adeno-associated virus	Molecular Medicine Virology
Cole, Susan	Roles of fringe genes and Notch signaling during mouse development. Analysis of cyclic mRNA_expression during somitogenesis: linking the Notch pathway and the segmentation clock.	Cell Biology Developmental Biology Gene Expression
Coppola, Vincenzo	Role of Neurotrophins and related molecules in cell growth and differentiation both in physiological and pathological conditions. Mouse modeling of cancer and other human diseases.	Cancer Biology Cell Biology
Croce, Carlo	Human cancer genetics; role of micro RNAS in cancer.	Cancer Biology
Dalbey, Ross	Protein secretion and membrane assembly; membrane and lipid biochemistry.	Cell Biology
Das, Hiranmoy Contact Information Only	Hematopoietic stem cell manipulation and evaluation of their effect on vascular disease models prior to clinical trial, factors affecting stem cell differentiation and function	Cell Biology Developmental Biology Molecular Medicine
Davis, Jonathan P.	Dr. Davis’ lab focuses on the cellular and molecular basis of muscle contraction and relaxation via understanding how calcium binding proteins/enzymes are appropriately “tuned” kinetically to respond to calcium transients in vitro and in vivo. One of the laboratory goals is to modulate cellular function through the design and engineering of calcium binding proteins.	Cell Biology Molecular Medicine Virology Other
Dawes, Adriana	In our lab, we are interested in understanding how spatial patterns in a cell can arise from small scale interactions between proteins. We use both theoretical and experimental approaches, using zygotes of the nematode worm Caenorhabditis elegans as our model organism.	Cell Biology Developmental Biology
Ding, Biao	Focus is on elucidating molecular mechanisms that govern defense responses mounted by plants after attack by virus pathogens. Model viruses are small positive sense RNA viruses (ie, Turnip crinkle virus, Bean pod mottle virus). Current projects include understand the role of temperature in RNA silencing-based antiviral defense, and how nonhost plants respond to virus invasions.	Plant Molecular Biology Virology
Doseff, Andrea	Mechanisms involved in cell death during the innate immune response and oncogenic transformation	Cancer Biology Molecular Medicine Other
Drew, Mark	Genetic, cell biological, and biochemical studies of the protozoan parasite Plasmodium falciparum in an effort to discover novel therapeutics to treat human malaria.	Cell Biology Molecular Medicine Other
El-Hodiri, Heithem Member, Graduate Studies Committee	Regulation of gene expression in early Xenopus neural development	Developmental Biology Gene Expression
Fischer, Andy	Neural development, regeneration, and survival of cells in the retina. In particular, neural stem cells that are found at the peripheral edge of the retina or those that are derived from the major type of glial cell in the retina, the Müller glia. Investigating the cellular and molecular mechanisms that control the proliferation and differentiation of neural precursors in the developing and mature retina.	Cell Biology Developmental Biology Molecular Neurobiology
Fishel, Richard	Biophysical chemistry and genetics of DNA repair.	DNA Replication/Repair
Fisk, Harold	Cell cycle regulation of the Mps1 family of protein kinases; centrosome duplication and spindle checkpoint control; mis-regulation of Mps1 and its role in genetic instability and cancer.	Cancer Biology Cell Biology Developmental Biology
Flanigan, Kevin
Fu, Haiyan	My major focus is to develop efficient approaches for gene delivery to the central nervous system (CNS), using recombinant adeno-associated virus vectors, to treat the neurological disease of Mucopolysaccharidosis (MPS) IIIB in patients.	Molecular Medicine Virology
Ganju, Ramesh K.	Chemokine-mediated breast cancer progression and metastasis; molecular mechanism of chemokine receptor CXCR4/CCR5-mediated pathogenesis during HIV infection; small molecular weight inhibitors for chemokine receptors and characterizing cross-talk between Slit/Robo and chemokine receptor pathways as a novel target for combating breast cancer metastasis and HIV infection.	Cancer Biology Cell Biology Molecular Medicine Virology Other
Garg, Vidu	Focus is on the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development, utilizing a combination of human genetic and molecular approaches to gain insight into the etiologies of congenital heart disease.	Developmental Biology Gene Expression
Ghoshal, Kalpana	Role of DNA methylation and microRNAs in liver disease.	Cancer Biology Cell Biology Gene Expression Molecular Medicine RNA Biology
Gopalan, Venkat	Biochemistry and applications of ribonuclease P, a catalytic RNP complex	Gene Expression Plant Molecular Biology RNA Biology
Green, Patrick	Molecular pathogenesis of human T-cell leukemia virus (HTLV); molecular biology of retrovirus replication; T-cell activation/transformation	Cancer Biology Cell Biology Gene Expression Virology
Grotewold, Erich	Control of gene expression; metabolic engineering; evolution of transcription factors	Gene Expression Plant Molecular Biology
Gu, Chen Graduate Studies Committee	Our research goals are to understand how ion channels are precisely localized to control neuronal excitability and how localization and function of ion channels are altered in neurodegenerative diseases.	Cell Biology Developmental Biology Molecular Neurobiology
Guttridge, Denis C.	NF-kappa β regulation of cell growth and differentiation	Cancer Biology Cell Biology Developmental Biology Gene Expression Molecular Medicine RNA Biology
Hai, Tsonwin Member, Graduate Studies Committee	Eukaryotic gene expression, stress responses, cell death (apoptosis), cell cycle regulation, signal transduction, molecular mechanisms of diseases including cancer, diabetes and liver dysfunction. Experimental systems include cell free system, cell culture, transgenic and knock-out mice models.	Cancer Biology Gene Expression Molecular Medicine Other
Hamel, Patrice	Redox factors and heme delivery systems involved in the maturation of chloroplast and mitochondrial c-type cytochromes, assembly of mutimeric complex I in mitochondria	Cell Biology Plant Molecular Biology
Harper, Scott Q.	Gene therapy for dominant genetic diseases using RNA interference (RNAi), with particular focus on muscular dystrophy and neurodegenerative disease.	Molecular Medicine Molecular Neurobiology
Henion, Paul	Developmental regulation of neural crest cell diversification	Cell Biology Molecular Neurobiology Other
Henkin, Tina	Regulation of gene expression; Bacillus subtilis; grampositive bacteria; transcription antitermination; transcription activation and repression; RNAstructure and function; tRNA	Gene Expression RNA Biology
Herman, Paul	Eukaryotic cell proliferation; ras protein signaling; RNA pol II transcription	Cancer Biology Cell Biology Gene Expression Molecular Medicine
Hollick, Jay	Heritable epigenetic variation represents a poorly understood, yet significant, component of evolutionary biology. We use genetic, cytogenetic, genomic, and molecular approaches in corn to understand both the molecular mechanism and biological function of paramutation - a process responsible for meiotically heritable epigenetic changes in gene regulation. Our studies highlight novel aspects of eukaryotic chromosome organization and function.	Developmental Biology Gene Expression Plant Molecular Biology RNA Biology
Hopper, Anita	Intracellular trafficking of RNA and proteins; Nucleus organization; RNA processing	Cell Biology Gene Expression RNA Biology
Huebner, Kay	The laboratory uses tissue culture, mouse models and studies of mouse and human tissues to investigate the role of genetic changes at common chromosome fragile sites in initiation or progression of cancer. We are currently focusing on the roles of two fragile genes, which are involved in deletions early in cancer development, and in our more translational projects are studying microRNA and gene expression profiles in subtypes of breast cancer.	Cancer Biology DNA Replication/Repair Gene Expression
Ibba, Michael	Our research is directed towards understanding the mechanisms that determine how cells ensure the accurate translation of the genetic code, and how changes in the underlying processes impact cellular health and contribute to microbial pathogenesis and disease. Many of these processes are essential and unique to particular systems, making them ideal potential drug targets.	Gene Expression Molecular Medicine RNA Biology
Jackman, Jane	The Jackman laboratory utilizes the principles and techniques of mechanistic enzymology and enzyme kinetics to elucidate the molecular mechanisms of tRNA processing enzymes.	RNA Biology Other
Jacob, Samson	Metallothionein gene expression; protein factors that modulate ribosomal RNA gene transcription; molecular mechanisms of action of 5-fluorouracil	Cancer Biology Gene Expression
Janssen, Paul	Muscle mechanics. EC coupling and energetics of cardiac muscle tissue, under physiological and pathophysiological conditions.	Molecular Medicine
Jhiang, Sissy	Protein tyrosine kinases and cancers; transgenic mice for human diseases; gene transfer of sodium/iodide symporter for radioiodine treatment in human cancers	Cancer Biology Gene Expression Molecular Medicine
Johnson, Robert	The Johnson laboratory uses mouse model systems to understand the molecular and genetic changes responsible for the development of pediatric brain tumors.	Cancer Biology Developmental Biology Gene Expression
Jontes, James	Role of cell adhesion molecules in the processes of synaptogenesis and circuit assembly in the developing zebrafish nervous system.	Cell Biology Developmental Biology Gene Expression Molecular Neurobiology
Kahn, Mahmood	Utilizing cell-based therapies (MSCs/iPS) for cardiac regeneration after myocardial infarction, with the special emphasis on the role hyperbaric oxygen (HBO) and microRNA's (miR's) in cardiovascular disease
Kaspar, Brian K	Investigation of cell death pathways in Central Nervous System Disorders; delivery of Gene Therapy Vectors to the CNS; identification of Neural Stem Cell Signaling Pathways and Development	Cell Biology Developmental Biology Gene Expression Molecular Medicine Molecular Neurobiology Virology
Kirschner, Lawrence	molecular events leading to the formation of tumors of the endocrine glands, and the relationship of these processes to the differentiation of these tissues	Cancer Biology Cell Biology Molecular Medicine
Kudryashov, Dmitri	Actin is an abundant eukaryotic protein involved in a variety of vital cellular events including, but not limited to cell migration, cytokinesis, endo- and exocytosis, organelle transport, and muscle contraction. We are interested in deciphering molecular and cellular mechanisms of actin-based processes, their regulation by actin binding proteins and disruption by bacterial and viral pathogens.	Cancer Biology Cell Biology Molecular Medicine
Kuret, Jeff	Molecular basis of neurodegenerative diseases	Cell Biology Molecular Neurobiology
Kvaratskhelia, Mamuka	Understand HIV replication, cancer development and DNA repair processes at the molecular level, using mass spectrometry as both a proteomic and structural biology tool to elucidate the composition and architecture of key biological macromolecules.	DNA Replication/Repair RNA Biology Virology
Kwiek, Jesse	Research in the Kwiek Lab focuses on the biology, pharmacology, and public health impact of Human Immunodeficiency Virus (HIV-1).	Virology
Kwon, Chang-Hyuk	Tumor drivers of glioblastoma; comparing genetic and epigenetic changes between origin (neural stem cells) and tumor cells during tumor development.	Cancer Biology Cell Biology Developmental Biology Gene Expression Molecular Medicine Molecular Neurobiology
Lamb, Rebecca	Role of transcriptional regulation during flower development in the model plant species Arabidopsis thaliana. Using specification of organ identity to study transcriptional networks controlling development. In addition to elucidating the molecular underpinnings of flower formation, the potential modification of transcriptional networks during evolution to give rise to varying floral morphologies is being examined.	Developmental Biology Gene Expression Plant Molecular Biology
Lee, Beth S.	Cell biology of osteoclasts with particular emphasis on differentiation and the cytoskeleton; mechanisms by which kidney tubule cells regulate mRNA levels during and following cellular stresses.	Cell Biology Gene Expression RNA Biology
Lee, L. James	Currently interested in both in vivo and in vitro delivery of siRNA and miRNA and their potential application in cancer and leukemia therapy. Research involves nanobiotechnology and biomaterials.	Gene Expression Molecular Medicine
Lee, Robert J.	Targeted drug delivery systems for cancer. Gene therapy. Antisense and siRNA therapy. Liposomes and nanoparticles for drug delivery. Nanoparticle based nanomedicines. Immunotherapy for cancer.	Cancer Biology Gene Expression Molecular Medicine
Leone, Gustavo W.	Cancer biology; control of cell growth and cell death	Cancer Biology Gene Expression
Lesinski, Gregory B.	Research focuses on understanding the interactions between the host immune system and tumor cells. Ultimate goal is to develop novel therapeutic or chemo-preventative approaches to help patients with cancer and improve existing therapies. Inhibition of the oncogenic STAT3 pathway and maximizing the effect of immune based therapy are of particular interest.	Cancer Biology Molecular Medicine
Lill, Nancy	Regulation of growth factor receptors; protein trafficking; signal transduction; mechanisms of cell transformation and oncogenesis; targeted protein degradation; anticancer therapeutics; protein-protein interations	Cancer Biology Cell Biology Molecular Medicine Other
Lilly, Brenda	The Lilly lab studies mechanisms of blood vessel formation and smooth muscle differentiation. Our specific interests include endothelial and smooth muscle cell interactions, mechanisms of Notch signaling, and transcriptional control of smooth muscle gene expression.	Cell Biology Developmental Biology Gene Expression Molecular Medicine
Lin, Jiayuh	Molecular mechanisms of activation of Signal Transducer and Activator of Transcription 3 (STAT3) pathway in human cancers; tyrosine kinase profile in human ovarian and bladder cancers, and Rhabdomyosarcomas; regulation of gene transcription and _expression by p53 tumor suppressor gene in cancer and normal cells.	Cancer Biology
Lin, Young	Roles of growth factors and steroidogenic enzymes in hormone-dependent cancers	Cancer Biology
Lincoln, Joy	Focus is on understanding embryonic origins of adult heart disease, with a specific interest in heart valves. Lab uses in vitro and in vivo tools in combination with molecular biology, bioengineering and imaging skills to examine the mechanisms of how heart valves form in the developing embryo, and how alterations in embryogenesis give rise to dysfunctional heart valves after birth.	Cell Biology Developmental Biology Gene Expression Molecular Medicine
Liu, Yusen	Signal transduction pathways that regulate the cellular responses to extracellular stimuli. Investigate the role of MAP kinase phosphatases in the regulation of inflammatory cytokine biosynthesis in macrophages during bacterial infection. Investigations the basic mechanisms of aging and the molecular mechanisms via which triptolide induces apoptosis in a variety of cancer cells.	Cancer Biology Cell Biology Gene Expression
Liu, Zhenguo	Stem cell differentiation; mechanisms and pharmacologic therapies of ventricular tachycardia
Lovett-Racke, Amy	My laboratory studies the pathophysiology of multiple sclerosis.	Molecular Neurobiology
Ludwig, Thomas	Functional analysis of the tumor suppressor genes BRCA1 and BRCA2 in normal and malignant development. Cancer biology. Animal models of human cancer.	Cancer Biology Cell Biology Developmental Biology DNA Replication/Repair Gene Expression
Ma, Jiyan	Transmissible Spongiform Encephalopathies (TSEs)	Cell Biology Molecular Neurobiology
Mackey, David	Pathogens secrete effector proteins that enhance virulence by functioning inside plant cells. Plants express resistance proteins that can sense effectors and induce an innate immune response. Current research focuses the molecular mechanisms of each of these processes.	Plant Molecular Biology Other
Mangel, Stuart	We are studying how a circadian (24-hour) clock modulates cellular and molecular processes and chemical and electrical synaptic transmission, and how disruption of this circadian system mediates neuronal degeneration. We are also studying the cellular, subcellular(eg transporters), developmental, and neural network mechanisms that underlie information processing in the brain.	Cell Biology Developmental Biology Molecular Neurobiology Other
Marcucci, Guido	Molecular Biology and Cancer Genetics, Experimental Therapeutics.	Cancer Biology Molecular Medicine
Marketon, Jeannette	My laboratory is interested in the molecular action of nuclear hormone receptors, particularly the glucocorticoid receptor.	Gene Expression
Marsh, Clay	Research centers on the roles of monocytes and macrophages in regulating inflammation and organ repair
Martin, Paul Taylor	Research in the Martin lab is focused on the role of glycoyslation in synapse formation and muscular dystrophy. Other studies involve understanding the role of carbohydrates in the development of the brain, and the development of diagnostic and therapeutic reagents for Alzheimer's disease.	Developmental Biology Molecular Medicine Molecular Neurobiology
McBride, Kim	Focus is on elucidating causes of cardiovascular malformations, with the goal of developing novel therapies. We apply a variety of human genetic techniques (linkage, association, sequencing) to identify and characterize candidate genes. Functional consequences are studied in cell based systems. We use genetic and environmental models to examine cardiovascular developmental biology in the mouse.	Cell Biology Developmental Biology Gene Expression Molecular Medicine Other
McCarty, Douglas M.	The biology of adeno-associated virus (AAV), and its used as a gene delivery system for the treatment of human disease	Virology Molecular Medicine
McHugh, Kirk	The research efforts in my laboratory rely upon an integrated scientific approach that is designed to identify the genetic pathways responsible for the ontogenesis and pathogenesis of smooth muscle tissues. The dysregulation of smooth muscle differentiation represe.	Cancer Biology Cell Biology Developmental Biology Gene Expression Molecular Medicine
Mehta, Kamal D.	Signaling and transcriptional mechanisms regulating cholesterol homeostasis	Gene Expression Molecular Medicine
Meier, Iris	Anchoring of Ran signal transduction in plants; nuclear pore and nuclear envelope protein function; genomic analysis of long coiled-coil proteins.	Cell Biology Plant Molecular Biology
Muthusamy, Natarajan	Research interests are focused on the following areas: 1) Biological therapies for hematological malignancies with primary focus on acute and chronic leukemia; 2) Development and characterization of clinically relevant animal models of lymphoid malignancies; 3) Targeted delivery of RNA based therapeutics in lymphoid and myeloid malignancies.	Cancer Biology Molecular Medicine
Mykytyn, Kirk	Molecular genetics of complex diseases.	Cell Biology Developmental Biology Molecular Medicine
Nankano, Ichiro	Characterization of cancer stem cells in brain tumors is the main project in the Nakano Lab. We seek to determine the signaling pathways regulating survival of brain tumor stem cells and to identify novel chemotherapeutic agents that eradicate these stem cells without causing side effects on behavior of normal neural stem cells in the brain.	Cancer Biology Cell Biology Molecular Medicine
Niewiesk, Stefan	Immune modulation by measles virus and vaccination in the presence of maternal antibodies.	Gene Expression Molecular Medicine Virology Other
Obrietan, Karl	Second messenger signaling and transcriptional pathways that regulate circadian timing: Ca2+, CREB and neuronal plasticity: peptidergic modulation of glutamatergic signaling	Gene Expression Molecular Neurobiology
Oglesbee, Michael	Role of cellular stress response/heat shock proteins in viral infection (measles, canine distemper virus).	Virology
Osmani, Stephen A.	Cell cycle; nuclear migration; fungal development	Cell Biology
Ostrowski, Michael	Nonnuclear oncogenes, ETS-family transcription factors, and the regulation of transcription during cellular differentiation and malignant transformation	Cancer Biology Cell Biology Gene Expression
Park, Hay-Oak	Regulation of Cell Growth and Oriented Cell Division; Oxidative Stress Response and Cell Death; GTPase signaling pathways	Cancer Biology Cell Biology Other
Parris, Deborah (CMIB) (MVIMG)	Herpes simplex virus; gene expression and DNA replication. Suppression of RNAi as a pathogenicity determinant for herpes simplex virus and Ebola virus.	DNA Replication/Repair Virology
Partida-Sanchez, Santiago Contact Information Only	Chemokine receptor signaling, generation of calcium second messengers, activation of calcium channels and their role in regulating migration of immune cells.	Cell Biology Molecular Medicine Other
Parthun, Mark	The role of histone posttranslational modifications in the formation and regulation of chromatin	Cancer Biology DNA Replication/Repair Gene Expression
Parvin, Jeffrey	Systems Biology, Breast Cancer, BRCA1, Ubiquitination	Cancer Biology DNA Replication/Repair Gene Expression
Pekarsky, Yuri	Investigation of the function of TCL1 oncogene	Cancer Biology
Periasamy, Muthu	Genomics and proteomics of the heart	Developmental Biology Gene Expression Molecular Medicine
Perrotti, Danilo	Research is aimed at assessing the molecular mechanisms leading to leukemic transformation of hematopoietic cells. Specific areas of interest are: a)Role of RNA binding proteins in blastic transformation of Chronic Myelogenous Leukemia; b) Signal transduction in Leukemia; c) Mechanisms regulating expression and activity of oncogenic kinases.	Cancer Biology
Pichiorri, Flavia	Elucidating the role of microRNAs and epigenetic aberrations in multiple myeloma (MM). Lab is also focused on studying the role of MM microvesicles in cell-cell communication and on preclinical evaluation in experimental therapeutics for clinical trials.	Cancer Biology Cell Biology Gene Expression RNA Biology
Pierson, Christopher R.	Elucidate the pathogenesis of the centronuclear myopathies, especially X-linked myotubular myopathy, and to develop novel therapies for these myopathies.	Molecular Medicine
Quan, Ning	The afferent pathways by which immune activity are transmitted to the central nervous system.	Cell Biology Gene Expression Molecular Neurobiology
Qu, Feng Contact Information only	Focus is on elucidating molecular mechanisms that govern defense responses mounted by plants after attack by virus pathogens. Model viruses are small positive sense RNA viruses (ie, Turnip crinkle virus, Bean pod mottle virus). Current projects include understand the role of temperature in RNA silencing-based antiviral defense, and how nonhost plants respond to virus invasions.	Plant Molecular Biology Virology
Rajagopalan, Sanjay	Our laboratory is interested in inflammatory and immune mechanisms involved in cardiometabolic diseases such as Type II diabetes and atherosclerosis. We use physiologic techniques in concert with advanced molecular and imaging based approaches to study inflammation in response to risk factors.
Ransom, Richard	Research is focused on the mechanism of action of corticosteroids in the common pediatric kidney disease, nephrotic syndrome. We are pursuing both cell biology experiments using cell models and a multi-center study using patient blood and RNA samples to address both the mechanism of corticosteroid action and resistance to steroids.	Cell Biology Molecular Medicine Other
Rikihisa, Yasuko	Molecular and cellular mechanism of intracellular parasitism/Ehrlichia spp	Cell Biology Gene Expression RNA Biology
Rosol, Thomas J.	The laboratory utilizes mouse models of human cancer to investigate the role of parathyroid hormone-related protein in bone metastasis and cancer-associated hypercalcemia. Metastases are monitored using in vivo bioluminescence of luciferase-transfected tumor cells. Molecular studies are focused on the regulation of PTHrP mRNA stability by transforming growth factor-s.	Cancer Biology Cell Biology Gene Expression Molecular Medicine RNA Biology
Sanders, Virginia	Research focuses on the molecular mechanisms by which the neurotransmitter norepinephrine and stimulation of the beta2-adrenergic receptor on T and B lymphocytes mediates important changes in adaptive immunity.	Cell Biology Gene Expression
Santangelo, Thomas J.	Lab focuses on transcription regulation in Archaea, from a detailed structure-function relationship of RNA polymerase to regulation imposed post-initiation at a genome-wide level. We leverage our capacity to genetically modify archaea to introduce and manipulate regulatory pathways to direct metabolic flux towards the production of high value products, including biohydrogen, butanol, and isoprenoids. In parallel we are developing the first archaeal comprehensive strain libraries for use in biomedical and biotechnology applications.	DNA Replication/Repair Gene Expression RNA Biology
Schmittgen, Thomas	Quantitative gene expression analysis, the role of small, noncoding (i.e. micro RNAs) in cancer.	Cancer Biology Gene Expression Other
Schoenberg, Daniel	Regulation of mRNAstability; pre-mRNA processing and translation initiation; posttranscriptional control by estrogen	Cancer Biology Cell Biology Gene Expression RNA Biology
Sen, Chandan (Laboratory) (Heart & Lung)	microRNA biology, tissue injury and repair, regenerative medicine, nutrition, oxygen and hypoxia, wound healing, stroke and neurodegeneration, myocardial infarction	Cell Biology Gene Expression Molecular Medicine Molecular Neurobiology
Shields, Peter G.	The Shields’ laboratory focuses on carcinogenesis, cancer risk and the development of new biomarkers for cancer risk. This involves a combined laboratory and epidemiology research program. The current emphasis is on diet and lifestyle, and using various omic’s technologies.	Cancer Biology Molecular Medicine
Sif, Said	Effects of human chromatin remodeling complexes on gene expression, cell growth and development	Cancer Biology Cell Biology Gene Expression
Simcox, Amanda	The role of oncogenes, tumor suppressors and Egfr signaling in growth control and development in Drosophila	Cancer Biology Developmental Biology Gene Expression
Slotkin, R. Keith	My laboratory aims to discover how potentially mutagenic “jumping genes” or transposable elements are epigenetically repressed from generation to generation, as well as how this system has been adopted over evolutionary time to regulate non-transposable element genes.	Developmental Biology Gene Expression Plant Molecular Biology RNA Biology
Somers, David	Molecular genetic analysis of the plant circadian clock	Developmental Biology Plant Molecular Biology
Strauch, Arthur Contact Information Only	Myogenesis; vascular cell biology; smooth-muscle actin gene expression	Cell Biology Gene Expression Molecular Medicine
Sun, Qinghua	Air pollution, exercise, and ambient temperature changes and exposures on human health, especially pulmonary and cardiovascular diseases and cancer.	Cell Biology Molecular Medicine
Suo, Zucai	Lab utilizes in vivo and in vitro techniques to understand Hepatitis C (HCV) replication and regulation of innate immunity. Also, employs pre-steady state kinetics, x-ray crystallography and single molecule spectroscopy to investigate the enzymes involved in DNA/RNA replication, repair, and lesion bypass.	DNA Replication/Repair
Symer, David	Causes and consequences of endogenous transposition and alternative RNA splicing in mouse and man.	Cancer Biology Developmental Biology Gene Expression RNA Biology Virology
Tabita,Robert	Molecular biology and genetic engineering of CO₂ metabolism	Gene Expression Plant Molecular Biology
Toland, Amanda	Identification and characterization of low penetrance cancer susceptibility genes.	Cancer Biology Molecular Medicine
Tridandapani, Susheela	My lab is primarily interested in dissecting the signal transduction processes involved in a) immune-complex clearance by macrophages, and the associated inflammation, and b) the inflammatory response to bacterial lipopolysaccharide.	Other
Wang, Qianben	Understanding the molecular pathological mechanisms underlying the development and progression of prostate cancer. Currently using chromatin immunoprecipitation (ChIP) combined with massively parallel sequencing (ChIP-seq) technique to study combinatorial transcriptional regulation by androgen receptor, collaborating transcription factors and histone modifications in prostate cancer cells. We will also apply the genome-wide ChIP technique to clinical samples obtained from different stages of prostate cancer, which would allow identification of critical cis-regulatory sequences contributing to prostate cancer progression.	Cancer Biology Gene Expression Molecular Medicine
Wewers, Mark D.	Lung macrophages monitor the boundary between the environment and the blood stream by the means of intracellular and surface pathogen recognition receptors. We are currently interested in understanding how the intracellular pathogen sensors (NOD-like receptors) work to regulate cytokines (especially IL-1beta) and cell death (apoptosis) via modulation of caspase-1.	Cell Biology Gene Expression Molecular Medicine
Wharton, Robin P.	Post-transcriptional gene regulation in Drosophila; germ cell biology.	Cell Biology Developmental Biology Gene Expression RNA Biology
Williams, Marshall	DNA replication and repair in eukaryotic cells and herpes viruses	DNA Replication/Repair Molecular Medicine Virology
Wold, Loren	Myocardial function and calcium signaling in disease
Wu, Jian-Qiu	Roles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal, cancer, and stem cells.	Cell Biology
Wu, Lai-Chu	V(D)J recombination; protein binding to recombination signal sequences	Cancer Biology Cell Biology Developmental Biology Gene Expression
Wu, Li	Research focuses on the molecular mechanisms by which immune cells disseminate HIV in order to facilitate the development of more effective interventions against HIV infection and transmission.	Cell Biology Gene Expression Virology
Yang, Shang-Tian
Yoon, Sung OK	Cell signaling; neuronal apoptosis; transgenic mice; myelination; role of small GTPases in brain development; nerve injury	Cancer Biology Cell Biology Developmental Biology Molecular Neurobiology
Yu, Chack-Yung	Molecular biology of the human major histocompatibility complex class III products and eukocyte antigen CD1.	Molecular Medicine RNA Biology
Yu, Jianhua	Objective of first research area is to investigate natural killer (NK) cell innate immune response to tumor cells through understanding signaling pathways, cell activation, cell subsets, and cell development of NK cells. The goal of the project is to perform NK cell-based immunotherapy to treat leukemia, glioblastoma or hepatocellular carcinoma. The second research area is regarding hematopoietic stem cell transplantation (HSCT). This includes stem cell mobilization and HSCT associated complications such as graft-versus-host disease (GVHD) and leukemia relapse.	Cancer Biology Cell Biology Developmental Biology Gene Expression Molecular Medicine Virology
Zhou, Min	The functional role of astrocyte potassium and gap junction channels in normal and stroke brain.	Cell Biology Molecular Neurobiology
Zou, Xianghong	Long-term goal is to develop therapeutic strategies to target the cell cycle machinery, specifically in the aggressive cancer	Cancer Biology Cell Biology
Zweier, Jay L.	Ischemic Heart Disease, Mechanisms of Postischemic Injury, Free Radicals and their role in Cellular Function and Disease, Magnetic Resonance Spectroscopy and Imaging.	Molecular Medicine

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MCDB Mentoring Faculty