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MCDB Faculty

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Name Research Interests Areas of Research
Ainslie, Kristy Drug delivery and applied immunology   OtherOther
Last Updated: 27-Sep-2011
Amer, Amal Host-pathogen interaction, f ocused on the role of cytosolic NOD-like receptors and their ability to activate inflammatory responses to combat pathogens and the role of caspases in innate immune response to pulmonary pathogens. Cell BiologyCell Biology
OtherOther
Asano, Maki
Graduate Studies Committee
We study the molecular mechanisms regulating the cell cycle progression, with focus on the initiation of DNA replication. We use Drosophila as a genetically and molecularly amenable model system. Cancer BiologyCancer Biology
Developmental BiologyDevelopmental Biology
DNA ReplicationDNA Replication/Repair
Gene ExpressionGene Expression
Askwith, Candice The role of acid-sensing ion channels in neuronal signaling. Molecular NeurobiologyMolecular Neurobiology
Bartlett, Christopher
Graduate Studies Committee
Focus on gene discovery for specific language impairment, autism and related cognitive traits OtherOther
Basu, Sujit
(Heart & Lung Institute)
(Pathology)
Angiogenesis and vasculogenesis; tumor microenvironment including cancer stem cells; preclinical cancer chemotherapy; neural immune cross talk in cancer. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
OtherOther
Beattie, Christine Elucidation of the underlying causes of motoneuron dysfunction in motoneuron diseases using zebrafish as a model system. Developmental BiologyDevelopmental Biology
Molecular NeurobiologyMolecular Neurobiology
Besner, Gail Use of growth factors in the treatment of intestinal ischemia/reperfusion injury. Cell BiologyCell Biology
Gene ExpressionGene Expression
Biesiadecki, Brandon Understanding the molecular mechanisms of how muscle protein post-translational modifications (phosphorylation, radical modification, degradation, etc) alter heart function Molecular MedicineMolecular Medicine
Bisaro,David
Program Director, Chair of the Graduate Studies Committee
Geminivirus replication, gene expression, and pathogenesis.  The role of small RNA-directed epigenetic silencing in defense against DNA viruses. Gene ExpressionGene Expression
Plant Molecular BiologyPlant Molecular Biology
RNA BiologyRNA Biology
VirologyVirology
Boris-Lawrie, Kathleen Post-transcription control of retroviruses; HIV-1 translation and RNA silencing suppression; Genome-wide analysis of RNA helicase A translation control. Gene ExpressionGene Expression
RNA BiologyRNA Biology
VirologyVirology
Boyaka, Prosper N. My research interests focus on the regulation of immunity and inflammation in mucosal surfaces. T helper cells differentiation, Mucosal immunity, Mucosal inflammation /allergy, Adjuvants and vaccines. Molecular MedicineMolecular Medicine
Boyd, R. Thomas Molecular neurobiology; nicotinic acetylcholine receptor genes. Gene ExpressionGene Expression
Brigstock, David Characterization of connective tissue growth factor: structure-function analysis and role in fibrotic disease Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Molecular MedicineMolecular Medicine
Brown, Anthony The mechanism of slow axonal transport Cell BiologyCell Biology
Molecular NeurobiologyMolecular Neurobiology
OtherOther
Burghes, Arthur
  Contact Information Only
Genetics of motor neuron disorders and the muscular dystrophies Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Chamberlin, Helen Understanding the molecular processes underlying organogenesis Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Chandler, Dawn
Member, Graduate Studies Committee
Cancer biology; regulation of pre-mRNA splicing in normal cellular function and disease. Cancer BiologyCancer Biology
Molecular NeurobiologyMolecular Neurobiology
RNA BiologyRNA Biology
Chang, Long-Sheng Retinoblastoma-family genes; neurofibromatosis 2 suppressor gene; serotonin 5-HT2C receptor; DNA polymerase d in aging, transgenic mice Cancer BiologyCancer Biology
Developmental BiologyDevelopmental Biology
DNA ReplicationDNA Replication/Repair
Gene ExpressionGene Expression
Molecular NeurobiologyMolecular Neurobiology
Chotani, Maqsood Molecular signaling in vascular smooth muscle cells and cardiac myocytes, the biology of the G protein coupled á2-adrenoceptor subtype C (á2C), and elucidating the role of Ras-related small GTPase Rap1 in the cardiovasculature. Cell BiologyCell Biology
Gene ExpressionGene Expression
OtherOther
Clark, K. Reed Molecular medicine, focusing on viral vectors, gene therapy, and adeno-associated virus Molecular MedicineMolecular Medicine
VirologyVirology
Cole, Susan Roles of fringe genes and Notch signaling during mouse development. Analysis of cyclic mRNA_expression during somitogenesis: linking the Notch pathway and the segmentation clock. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Croce, Carlo Human cancer genetics; role of micro RNAS in cancer. Cancer BiologyCancer Biology
Dalbey, Ross Protein secretion and membrane assembly; membrane and lipid biochemistry. Cell BiologyCell Biology
Daniels, Charles Molecular biology of Archaea: tRNA intron processing, RNAseP, small RNAs, regulation of gene expression, evolution of the transcriptional apparatus, and genome analysis. Gene ExpressionGene Expression
RNA BiologyRNA Biology
Das, Hiranmoy
  Contact Information Only
Hematopoietic stem cell manipulation and evaluation of their effect on vascular disease models prior to clinical trial, factors affecting stem cell differentiation and function Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Molecular MedicineMolecular Medicine
DeWille, James Investigation of a protein that functions as a transcription factor and regulates mammary epithelial cell growth, death, and differentiation Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Ding, Biao Focus is on elucidating molecular mechanisms that govern defense responses mounted by plants after attack by virus pathogens. Model viruses are small positive sense RNA viruses (ie, Turnip crinkle virus, Bean pod mottle virus). Current projects include understand the role of temperature in RNA silencing-based antiviral defense, and how nonhost plants respond to virus invasions. Plant Molecular BiologyPlant Molecular Biology
VirologyVirology
Doseff, Andrea Mechanisms involved in cell death during the innate immune response and oncogenic transformation Cancer BiologyCancer Biology
Molecular MedicineMolecular Medicine
OtherOther
Drew, Mark Genetic, cell biological, and biochemical studies of the protozoan parasite Plasmodium falciparum in an effort to discover novel therapeutics to treat human malaria. Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
OtherOther
El-Hodiri, Heithem
Member, Graduate Studies Committee
Regulation of gene expression in early Xenopus neural development Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Fischer, Andy Neural development, regeneration, and survival of cells in the retina. In particular, neural stem cells that are found at the peripheral edge of the retina or those that are derived from the major type of glial cell in the retina, the Müller glia. Investigating the cellular and molecular mechanisms that control the proliferation and differentiation of neural precursors in the developing and mature retina. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Molecular NeurobiologyMolecular Neurobiology
Fishel, Richard Biophysical chemistry and genetics of DNA repair. DNA ReplicationDNA Replication/Repair
Fisk, Harold Cell cycle regulation of the Mps1 family of protein kinases; centrosome duplication and spindle checkpoint control; mis-regulation of Mps1 and its role in genetic instability and cancer. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Flanigan, Kevin    
Fu, Haiyan My major focus is to develop efficient approaches for gene delivery to the central nervous system (CNS), using recombinant adeno-associated virus vectors, to treat the neurological disease of Mucopolysaccharidosis (MPS) IIIB in patients. Molecular MedicineMolecular Medicine
VirologyVirology
Fuerst, Paul Molecular evolution of rRNA genes in intracellular bacteria and in algae. OtherOther
Ganju, Ramesh K. Chemokine-mediated breast cancer progression and metastasis; molecular mechanism of chemokine receptor CXCR4/CCR5-mediated pathogenesis during HIV infection; small molecular weight inhibitors for chemokine receptors and characterizing cross-talk between Slit/Robo and chemokine receptor pathways as a novel target for combating breast cancer metastasis and HIV infection. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
VirologyVirology
OtherOther
Garg, Vidu Focus is on the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development, utilizing a combination of human genetic and molecular approaches to gain insight into the etiologies of congenital heart disease. Gene ExpressionGene Expression
Developmental BiologyDevelopmental Biology
Gopalan, Venkat Biochemistry and applications of ribonuclease P, a catalytic RNP complex Gene ExpressionGene Expression
Plant Molecular BiologyPlant Molecular Biology
RNA BiologyRNA Biology
Green, Patrick Molecular pathogenesis of human T-cell leukemia virus (HTLV); molecular biology of retrovirus replication; T-cell activation/transformation Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
VirologyVirology
Grotewold, Erich Control of gene expression; metabolic engineering; evolution of transcription factors Gene ExpressionGene Expression
Plant Molecular BiologyPlant Molecular Biology
Gu, Chen
Graduate Studies Committee
Our research goals are to understand how ion channels are precisely localized to control neuronal excitability and how localization and function of ion channels are altered in neurodegenerative diseases. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Molecular NeurobiologyMolecular Neurobiology
Guttridge, Denis C. NF-kappa β regulation of cell growth and differentiation Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
RNA BiologyRNA Biology
Hackshaw, Kevin Autoimmune disorders; growth factors involved in the inflammatory cascade Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Hai, Tsonwin
Member, Graduate Studies Committee
Eukaryotic gene expression, stress responses, cell death (apoptosis), cell cycle regulation, signal transduction, molecular mechanisms of diseases including cancer, diabetes and liver dysfunction. Experimental systems include cell free system, cell culture, transgenic and knock-out mice models. Cancer BiologyCancer Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
OtherOther
Hamel, Patrice Redox factors and heme delivery systems involved in the maturation of chloroplast and mitochondrial c-type cytochromes, assembly of mutimeric complex I in mitochondria Cell BiologyCell Biology
Plant Molecular BiologyPlant Molecular Biology
Harper, Scott Q. Gene therapy for dominant genetic diseases using RNA interference (RNAi), with particular focus on muscular dystrophy and neurodegenerative disease. Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Hassanain, Hamdy
(Anesthesiology)
(Heart & Lung)
Molecular cardiovascular research, transgenic models for cardiovascular diseases, gene chip analysis to identify putative genes involved in cardiovascular diseases, signal mechanism involved in cardiovascular diseases. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
DNA ReplicationDNA Replication/Repair
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Henion, Paul Developmental regulation of neural crest cell diversification Cell BiologyCell Biology
Molecular NeurobiologyMolecular Neurobiology
OtherOther
Henkin, Tina Regulation of gene expression; Bacillus subtilis; grampositive bacteria; transcription antitermination; transcription activation and repression; RNAstructure and function; tRNA Gene ExpressionGene Expression
RNA BiologyRNA Biology
Herman, Gail X-linked developmental disorders; human and mouse genetics Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Herman, Paul Eukaryotic cell proliferation; ras protein signaling; RNA pol II transcription Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Hopper, Anita Intracellular trafficking of RNA and proteins; Nucleus organization; RNA processing Cell BiologyCell Biology
Gene ExpressionGene Expression
RNA BiologyRNA Biology
Hopper, James My research focuses on transcription or gene switches and how cells use them to evolve strategies that allow appropriate responses to environmental changes. Cell BiologyCell Biology
Gene ExpressionGene Expression
Hoyt, Dale Pulmonary and cardiovascular diseases Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
OtherOther
Huang, Tim H.M. Use integrative tools combining an experimental and bioinformatics approach to study complex epigenetic alterations in cancer and other diseases. Cancer BiologyCancer Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Jackman, Jane The Jackman laboratory utilizes the principles and techniques of mechanistic enzymology and enzyme kinetics to elucidate the molecular mechanisms of tRNA processing enzymes.

RNA BiologyRNA Biology
OtherOther

Jacob, Samson Metallothionein gene expression; protein factors that modulate ribosomal RNA gene transcription; molecular mechanisms of action of 5-fluorouracil Cancer BiologyCancer Biology
Gene ExpressionGene Expression
Jang, Jyun-Chyun Sugar and steroid hormone action and signal transduction in higher plants Plant Molecular BiologyPlant Molecular Biology
Developmental BiologyDevelopmental Biology
Janssen, Paul Muscle mechanics. EC coupling and energetics of cardiac muscle tissue, under physiological and pathophysiological conditions. Molecular MedicineMolecular Medicine
Jhiang, Sissy Protein tyrosine kinases and cancers; transgenic mice for human diseases; gene transfer of sodium/iodide symporter for radioiodine treatment in human cancers Cancer BiologyCancer Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Jontes, James Role of cell adhesion molecules in the processes of synaptogenesis and circuit assembly in the developing zebrafish nervous system. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular NeurobiologyMolecular Neurobiology
Kahn, Mahmood <empty>Utilizing cell-based therapies (MSCs/iPS) for cardiac regeneration after myocardial infarction, with the special emphasis on the role hyperbaric oxygen (HBO) and microRNA's (miR's) in cardiovascular disease <empty>
Kaspar, Brian K Investigation of cell death pathways in Central Nervous System Disorders; delivery of Gene Therapy Vectors to the CNS; identification of Neural Stem Cell Signaling Pathways and Development Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
VirologyVirology
Kirschner, Lawrence molecular events leading to the formation of tumors of the endocrine glands, and the relationship of these processes to the differentiation of these tissues Cancer BiologyCancer Biology
Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
Kitagawa, Risa Focus on elucidation of molecular mechanisms of maintenance of genome stability using C. elegans as a model organism to study physiologic function of the Spindle Assembly Checkpoint in multicellular organisms Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Kniss, Douglas Biochemical and molecular regulation of inflammation Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
Kuret, Jeff Molecular basis of neurodegenerative diseases Cell BiologyCell Biology
Molecular NeurobiologyMolecular Neurobiology
Kvaratskhelia, Mamuka Understand HIV replication, cancer development and DNA repair processes at the molecular level, using mass spectrometry as both a proteomic and structural biology tool to elucidate the composition and architecture of key biological macromolecules. DNA ReplicationDNA Replication/Repair
RNA BiologyRNA Biology
VirologyVirology
Kwon, Chang-Hyuk Tumor drivers of glioblastoma; comparing genetic and epigenetic changes between origin (neural stem cells) and tumor cells during tumor development. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Lairmore, Michael Transcription regulation and immunopathogenesis of human retroviruses HIV and HTLV-I Cancer BiologyCancer Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
VirologyVirology
Lamb, Rebecca Role of transcriptional regulation during flower development in the model plant species Arabidopsis thaliana. Using specification of organ identity to study transcriptional networks controlling development. In addition to elucidating the molecular underpinnings of flower formation, the potential modification of transcriptional networks during evolution to give rise to varying floral morphologies is being examined. Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Plant Molecular BiologyPlant Molecular Biology
Lang, James Role of oncogenes in cancer causation Cancer BiologyCancer Biology
Molecular MedicineMolecular Medicine
Lasky, Larry
CV Only
Hematopoiesis, with emphasis on applications in transfusion medicine. Cell BiologyCell Biology
Gene ExpressionGene Expression
Lee, Beth S. Cell biology of osteoclasts with particular emphasis on differentiation and the cytoskeleton; mechanisms by which kidney tubule cells regulate mRNA levels during and following cellular stresses. Cell BiologyCell Biology
Gene ExpressionGene Expression
RNA BiologyRNA Biology
Lee, L. James Currently interested in both in vivo and in vitro delivery of siRNA and miRNA and their potential application in cancer and leukemia therapy. Research involves nanobiotechnology and biomaterials. Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Lee, Robert J. Targeted drug delivery systems for cancer. Gene therapy. Antisense and siRNA therapy. Liposomes and nanoparticles for drug delivery. Nanoparticle based nanomedicines. Immunotherapy for cancer. Cancer BiologyCancer Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Leone, Gustavo W. Cancer biology; control of cell growth and cell death Cancer BiologyCancer Biology
Gene ExpressionGene Expression
Lesinski, Gregory B. Research focuses on understanding the interactions between the host immune system and tumor cells. Ultimate goal is to develop novel therapeutic or chemo-preventative approaches to help patients with cancer and improve existing therapies. Inhibition of the oncogenic STAT3 pathway and maximizing the effect of immune based therapy are of particular interest. Cancer BiologyCancer Biology
Molecular MedicineMolecular Medicine
Lill, Nancy Regulation of growth factor receptors; protein trafficking; signal transduction; mechanisms of cell transformation and oncogenesis; targeted protein degradation; anticancer therapeutics; protein-protein interations Cancer BiologyCancer Biology
Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
OtherOther
Lin, Huey-Jen My laboratory has examined how tumor suppressor genes can be epigenetically silenced in malignant breast epithelial cells, particularly the aberrant event commanded by cancer-associated fibroblasts. The signaling pathways governing the epigenomic perturbations comprised the main research streamlines. Our studies would depict a causal mechanism defining how tumor-microenvironment conveys DNA hypermethylation and leads to silencing of tumor suppressor genes in breast epithelia, events may virtually promote breast tumorigenesis. Cancer BiologyCancer Biology
OtherOther
Lin, Jiayuh Molecular mechanisms of activation of Signal Transducer and Activator of Transcription 3 (STAT3) pathway in human cancers; tyrosine kinase profile in human ovarian and bladder cancers, and Rhabdomyosarcomas; regulation of gene transcription and _expression by p53 tumor suppressor gene in cancer and normal cells. Cancer BiologyCancer Biology
Lin, Young Roles of growth factors and steroidogenic enzymes in hormone-dependent cancers Cancer BiologyCancer Biology
Liu, Yusen Signal transduction pathways that regulate the cellular responses to extracellular stimuli. Investigate the role of MAP kinase phosphatases in the regulation of inflammatory cytokine biosynthesis in macrophages during bacterial infection. Investigations the basic mechanisms of aging and the molecular mechanisms via which triptolide induces apoptosis in a variety of cancer cells. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Liu, Zhenguo Stem cell differentiation; mechanisms and pharmacologic therapies of ventricular tachycardia <empty>
Lovett-Racke, Amy My laboratory studies the pathophysiology of multiple sclerosis. Molecular NeurobiologyMolecular Neurobiology
Ma, Jiyan Transmissible Spongiform Encephalopathies (TSEs) Cell BiologyCell Biology
Molecular NeurobiologyMolecular Neurobiology
Mackey, David Pathogens secrete effector proteins that enhance virulence by functioning inside plant cells. Plants express resistance proteins that can sense effectors and induce an innate immune response. Current research focuses the molecular mechanisms of each of these processes. Plant Molecular BiologyPlant Molecular Biology
OtherOther
Mangel, Stuart We are studying how a circadian (24-hour) clock modulates cellular and molecular processes and chemical and electrical synaptic transmission, and how disruption of this circadian system mediates neuronal degeneration. We are also studying the cellular, subcellular(eg transporters), developmental, and neural network mechanisms that underlie information processing in the brain. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Molecular NeurobiologyMolecular Neurobiology
OtherOther
Marcucci, Guido Molecular Biology and Cancer Genetics, Experimental Therapeutics. Cancer BiologyCancer Biology
Molecular MedicineMolecular Medicine
Marketon, Jeannette My laboratory is interested in the molecular action of nuclear hormone receptors, particularly the glucocorticoid receptor. Gene ExpressionGene Expression
Marsh, Clay Research centers on the roles of monocytes and macrophages in regulating inflammation and organ repair <empty>
Martin, Paul Taylor Research in the Martin lab is focused on the role of glycoyslation in synapse formation and muscular dystrophy. Other studies involve understanding the role of carbohydrates in the development of the brain, and the development of diagnostic and therapeutic reagents for Alzheimer's disease. Developmental BiologyDevelopmental Biology
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
McBride, Kim Focus is on elucidating causes of cardiovascular malformations, with the goal of developing novel therapies. We apply a variety of human genetic techniques (linkage, association, sequencing) to identify and characterize candidate genes. Functional consequences are studied in cell based systems. We use genetic and environmental models to examine cardiovascular developmental biology in the mouse. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
OtherOther
McCarty, Douglas M. The biology of adeno-associated virus (AAV), and its used as a gene delivery system for the treatment of human disease VirologyVirology
Molecular MedicineMolecular Medicine
McHugh, Kirk The research efforts in my laboratory rely upon an integrated scientific approach that is designed to identify the genetic pathways responsible for the ontogenesis and pathogenesis of smooth muscle tissues. The dysregulation of smooth muscle differentiation represe. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Mehta, Kamal D. Signaling and transcriptional mechanisms regulating cholesterol homeostasis Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Meier, Iris Molecular analysis of the plant nuclear matrix Cell BiologyCell Biology
Plant Molecular BiologyPlant Molecular Biology
Mendell, Jerry R. I am a translational scientist whose laboratory works on projects that test experimental paradigms that can potentially be brought to clinical trial. The disease focus is muscular dystrophy and the major experimental tool is gene therapy. In the laboratory we are currently testing gene therapy in dysferlin and dystrophin deficient mice, and in the clinic we are doing gene therapy on patients using alpha-sarcoglycan, follistatin, and mini-dystrophin. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
RNA BiologyRNA Biology
Munson, Robert Molecular pathogenesis of Haemophilus infections OtherOther
Mykytyn, Kirk Molecular genetics of complex diseases. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Molecular MedicineMolecular Medicine
Nankano, Ichiro Characterization of cancer stem cells in brain tumors is the main project in the Nakano Lab. We seek to determine the signaling pathways regulating survival of brain tumor stem cells and to identify novel chemotherapeutic agents that eradicate these stem cells without causing side effects on behavior of normal neural stem cells in the brain. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
Niewiesk, Stefan Immune modulation by measles virus and vaccination in the presence of maternal antibodies. Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
VirologyVirology
OtherOther
Nishijima, Ichiko Identify and characterize the genetic factors causing human developmental disorders. Developmental BiologyDevelopmental Biology
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Oberdick, John Genetic control of mammalian brain development Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular NeurobiologyMolecular Neurobiology
RNA BiologyRNA Biology
Obrietan, Karl Second messenger signaling and transcriptional pathways that regulate circadian timing: Ca2+, CREB and neuronal plasticity: peptidergic modulation of glutamatergic signaling Gene ExpressionGene Expression
Molecular NeurobiologyMolecular Neurobiology
Oglesbee, Michael Role of cellular stress response/heat shock proteins in viral infection (measles, canine distemper virus). VirologyVirology
Osmani, Stephen A. Cell cycle; nuclear migration; fungal development Cell BiologyCell Biology
Ostrowski, Michael Nonnuclear oncogenes, ETS-family transcription factors, and the regulation of transcription during cellular differentiation and malignant transformation Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Park, Hay-Oak Regulation of Cell Growth and Oriented Cell Division; Oxidative Stress Response and Cell Death; GTPase signaling pathways Cancer BiologyCancer Biology
Cell BiologyCell Biology
OtherOther
Parris, Deborah
(CMIB)
(MVIMG)
Herpes simplex virus; gene expression and DNA replication. Suppression of RNAi as a pathogenicity determinant for herpes simplex virus
and Ebola virus.
DNA ReplicationDNA Replication/Repair
VirologyVirology
Partida-Sanchez, Santiago
 Contact Information Only
Chemokine receptor signaling, generation of calcium second messengers, activation of calcium channels and their role in regulating migration of immune cells. Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
OtherOther
Parthun, Mark The role of histone posttranslational modifications in the formation and regulation of chromatin Cancer BiologyCancer Biology
DNA ReplicationDNA Replication/Repair
Gene ExpressionGene Expression
Parvin, Jeffrey Systems Biology, Breast Cancer, BRCA1, Ubiquitination Cancer BiologyCancer Biology
DNA ReplicationDNA Replication/Repair
Gene ExpressionGene Expression
Pekarsky, Yuri Investigation of the function of TCL1 oncogene Cancer BiologyCancer Biology
Periasamy, Muthu Genomics and proteomics of the heart Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Perrotti, Danilo Research is aimed at assessing the molecular mechanisms leading to leukemic transformation of hematopoietic cells. Specific areas of interest are: a)Role of RNA binding proteins in blastic transformation of Chronic Myelogenous Leukemia; b) Signal transduction in Leukemia; c) Mechanisms regulating expression and activity of oncogenic kinases. Cancer BiologyCancer Biology
Phiel, Christopher Understanding the interface between signal transduction and epigenetics. Developmental BiologyDevelopmental Biology
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Pierson, Christopher R. Elucidate the pathogenesis of the centronuclear myopathies, especially X-linked myotubular myopathy, and to develop novel therapies for these myopathies. Molecular MedicineMolecular Medicine
Popovich, Phillip Neuron-immune interactions in models of CNS trauma, spinal cord injury; mechanisms of neuronal and glial toxicity triggered by innate and adaptive immune system; role of neuroinflammatory processes in glial tumor formation/progression. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular NeurobiologyMolecular Neurobiology
OtherOther
Quan, Ning The afferent pathways by which immune activity are transmitted to the central nervous system. Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular NeurobiologyMolecular Neurobiology
Qu, Feng
  Contact Information only
Focus is on elucidating molecular mechanisms that govern defense responses mounted by plants after attack by virus pathogens. Model viruses are small positive sense RNA viruses (ie, Turnip crinkle virus, Bean pod mottle virus). Current projects include understand the role of temperature in RNA silencing-based antiviral defense, and how nonhost plants respond to virus invasions. Plant Molecular BiologyPlant Molecular Biology
VirologyVirology
Rafael-Fortney, Jill Mouse models of neuromuscular diseases Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
Raffel, Cory The focus of the Raffel Lab is to develop alternative treatment for  medulloblastoma in children using recombinant measles virus  
Ransom, Richard Research is focused on the mechanism of action of corticosteroids in the common pediatric kidney disease, nephrotic syndrome. We are pursuing both cell biology experiments using cell models and a multi-center study using patient blood and RNA samples to address both the mechanism of corticosteroid action and resistance to steroids. Cell BiologyCell Biology
Molecular MedicineMolecular Medicine
OtherOther
Rikihisa, Yasuko Molecular and cellular mechanism of intracellular parasitism/Ehrlichia spp Cell BiologyCell Biology
Gene ExpressionGene Expression
RNA BiologyRNA Biology
Rosol, Thomas J. The laboratory utilizes mouse models of human cancer to investigate the role of parathyroid hormone-related protein in bone metastasis and cancer-associated hypercalcemia. Metastases are monitored using in vivo bioluminescence of luciferase-transfected tumor cells. Molecular studies are focused on the regulation of PTHrP mRNA stability by transforming growth factor-s. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
RNA BiologyRNA Biology
Rotter, Andrej Bioinformatics and computational biology of neural signaling molecules Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular NeurobiologyMolecular Neurobiology
Roy, Sashwati Primary focus is study of significance and mechanisms of resolution of inflammation in tissue repair and regeneration. Interested in the role of macrophages in resolution of inflammation during pathological tissue repair such as diabetic wound healing. Lab uses state of the art technologies such as laser capture microdissection and microarray expression (mRNA and miRNA) profiling to address these research questions. Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
OtherOther
Sanders, Virginia
Research focuses on the molecular mechanisms by which the neurotransmitter norepinephrine and stimulation of the beta2-adrenergic receptor on T and B lymphocytes mediates important changes in adaptive immunity. Cell BiologyCell Biology
Gene ExpressionGene Expression
Schmittgen, Thomas
Quantitative gene expression analysis, the role of small, noncoding (i.e. micro RNAs) in cancer. Cancer BiologyCancer Biology
Gene ExpressionGene Expression
OtherOther
Schoenberg, Daniel Regulation of mRNAstability; pre-mRNA processing and translation initiation; posttranscriptional control by estrogen Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
RNA BiologyRNA Biology
Seeger, Mark Molecular genetic analysis of axon pathfinding and synaptic target recognition mechanisms in Drosophila. Developmental BiologyDevelopmental Biology
Molecular NeurobiologyMolecular Neurobiology
Sen, Chandan
  (Laboratory)
  (Heart & Lung)
microRNA biology, tissue injury and repair, regenerative medicine, nutrition, oxygen and hypoxia, wound healing, stroke and neurodegeneration, myocardial infarction Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Sif, Said Effects of human chromatin remodeling complexes on gene expression, cell growth and development Cancer BiologyCancer Biology
Cell BiologyCell Biology
Gene ExpressionGene Expression
Simcox, Amanda The role of oncogenes, tumor suppressors and Egfr signaling in growth control and development in Drosophila Cancer BiologyCancer Biology
Developmental BiologyDevelopmental Biology

Gene ExpressionGene Expression
Slotkin, R. Keith My laboratory aims to discover how potentially mutagenic “jumping genes” or transposable elements are epigenetically repressed from generation to generation, as well as how this system has been adopted over evolutionary time to regulate non-transposable element genes. Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Plant Molecular BiologyPlant Molecular Biology
RNA BiologyRNA Biology
Snapka, Robert DNAreplication; DNAtopoisomerases; mechanisms of anticancer drugs Cancer BiologyCancer Biology
DNA ReplicationDNA Replication/Repair
Molecular MedicineMolecular Medicine
VirologyVirology
OtherOther
Somers, David Molecular genetic analysis of the plant circadian clock Developmental BiologyDevelopmental Biology
Plant Molecular BiologyPlant Molecular Biology
Strauch, Arthur
  Contact Information Only
Myogenesis; vascular cell biology; smooth-muscle actin gene expression Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Suo, Zucai Molecular mechanisms of enzymes involved in genome replication and natural product biosynthesis using a variety of techniques in enzymology, molecular biology, and synthetic chemistry DNA ReplicationDNA Replication/Repair
Tabita,Robert Molecular biology and genetic engineering of CO2 metabolism Gene ExpressionGene Expression
Plant Molecular BiologyPlant Molecular Biology
Toland, Amanda Identification and characterization of low penetrance cancer susceptibility genes. Cancer BiologyCancer Biology
Molecular MedicineMolecular Medicine
Trgovcich, Joanne
  Contact Information Only
Research focuses on the discovery and characterization of strategies by which herpes simplex type 1 and cytomegalo viruses evade host immune responses. Towards this end, we are investigating (1) the biology of these ancient viruses at a molecular/genetic level, (2) the mechanisms by which viral gene products subvert cellular functions, and (3) the pathogenesis of these virus infections. Cell BiologyCell Biology
VirologyVirology
Tridandapani, Susheela My lab is primarily interested in dissecting the signal transduction processes involved in a) immune-complex clearance by macrophages, and the associated inflammation, and b) the inflammatory response to bacterial lipopolysaccharide. OtherOther
Vaessin, Harald
Member, Graduate Studies Committee
Neurogenesis; neuronal precursor formation and differentiation in Drosophila Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular NeurobiologyMolecular Neurobiology
Vandré, Dale Regulation of the microtubule cytoskeleton during cell-cycle progression and in Alzheimer's disease. Cancer BiologyCancer Biology
Cell BiologyCell Biology
Molecular NeurobiologyMolecular Neurobiology
Verma, Desh Pal Vesicle trafficking and building of cell plate during cytokinesis in plants Cell BiologyCell Biology
Plant Molecular BiologyPlant Molecular Biology
Viapiano, Mariano Organization and functions of the extracellular matrix in central nervous system development and disease. Molecular NeurobiologyMolecular Neurobiology
Villamena, Frederick Free radical detection; development of synthetic antioxidants and radical probes; mechanisms of cytoprotection and cardioprotection by anitoxidants. Molecular MedicineMolecular Medicine
OtherOther
Waldman, James
  
(CMIB)
  (Heart & Lung)
Antiviral drug discovery and pre-clinical development, endothelium-targeted humoral autoimmune processes in pulmonary disease and neuro-opthalmic disorders, chemical and biological reactivity of airborne nano-particulates Molecular MedicineMolecular Medicine
Wang, Qianben Understanding the molecular pathological mechanisms underlying the development and progression of prostate cancer. Currently using chromatin immunoprecipitation (ChIP) combined with massively parallel sequencing (ChIP-seq) technique to study combinatorial transcriptional regulation by androgen receptor, collaborating transcription factors and histone modifications in prostate cancer cells. We will also apply the genome-wide ChIP technique to clinical samples obtained from different stages of prostate cancer, which would allow identification of critical cis-regulatory sequences contributing to prostate cancer progression. Cancer BiologyCancer Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Weghorst, Christopher Molecular mechanisms of human oral cancer; comparative molecular carcinogenesis; chemoprevention strategies. Cancer BiologyCancer Biology
Weinstein, Michael Analysis of mammalian development and disease using transgenic and knockout mouse models Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Wewers, Mark D. Lung macrophages monitor the boundary between the environment and the blood stream by the means of intracellular and surface pathogen recognition receptors. We are currently interested in understanding how the intracellular pathogen sensors (NOD-like receptors) work to regulate cytokines (especially IL-1beta) and cell death (apoptosis) via modulation of caspase-1. Cell BiologyCell Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Wharton, Robin P. Post-transcriptional gene regulation in Drosophila; germ cell biology. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
RNA BiologyRNA Biology
Williams, Marshall DNA replication and repair in eukaryotic cells and herpes viruses DNA ReplicationDNA Replication/Repair
Molecular MedicineMolecular Medicine
VirologyVirology
Wilson, Thomas My laboratory investigates the molecular biology and genetics of juvenile hormone in Drosophila. This hormone is a major player in insect development, metamorphosis, and reproduction, and we are studying how the hormone works at the molecular level. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Wold, Loren Myocardial function and calcium signaling in disease <empty>
Wu, Jian-Qiu Roles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal, cancer, and stem cells. Cell BiologyCell Biology
Wu, Lai-Chu V(D)J recombination; protein binding to recombination signal sequences Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Wu, Li Research focuses on the molecular mechanisms by which immune cells disseminate HIV in order to facilitate the development of more effective interventions against HIV infection and transmission. Cell BiologyCell Biology
Gene ExpressionGene Expression
VirologyVirology
Yang, Shang-Tian <empty> <empty>
Yoon, Sung OK Cell signaling; neuronal apoptosis; transgenic mice; myelination; role of small GTPases in brain development; nerve injury Cancer BiologyCancer Biology
Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Molecular NeurobiologyMolecular Neurobiology
Young, Tony Regulation of gene expression in the CNS, with an emphasis on Glutamine synthetase and nitric oxide synthase - their roles in excitotoxic neuronal cell death. Cell BiologyCell Biology
Developmental BiologyDevelopmental Biology
Gene ExpressionGene Expression
Molecular MedicineMolecular Medicine
Molecular NeurobiologyMolecular Neurobiology
Yu, Chack-Yung Molecular biology of the human major histocompatibility complex class III products and eukocyte antigen CD1. Molecular MedicineMolecular Medicine
RNA BiologyRNA Biology
Zou, Xianghong Long-term goal is to develop therapeutic strategies to target the cell cycle machinery, specifically in the aggressive cancer Cancer BiologyCancer Biology
Cell BiologyCell Biology
Zweier, Jay L. Ischemic Heart Disease, Mechanisms of Postischemic Injury, Free Radicals and their role in Cellular Function and Disease, Magnetic Resonance Spectroscopy and Imaging. Molecular MedicineMolecular Medicine