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Ma, Jiyan
|
Transmissible Spongiform Encephalopathies (TSEs)
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Mackey, David
|
Pathogens secrete effector proteins that enhance virulence by functioning inside plant cells. Plants express resistance proteins that can sense effectors and induce an innate immune response. Current research focuses the molecular mechanisms of each of these processes. |
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Martin, Paul Taylor
|
Research in the Martin lab is focused on the role of glycoyslation in synapse formation and muscular
dystrophy. Other studies involve understanding the role of carbohydrates in the development of the brain,
and the development of diagnostic and therapeutic reagents for Alzheimer's disease.
|
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Mangel, Stuart
|
We are studying how a circadian (24-hour) clock modulates cellular and molecular processes and chemical and
electrical synaptic transmission, and how disruption of this circadian system mediates neuronal degeneration.
We are also studying the cellular, subcellular(eg transporters), developmental, and neural network mechanisms that
underlie information processing in the brain.
|
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McCarty, Douglas M.
|
The biology of adeno-associated virus (AAV), and its used as a gene delivery system for the treatment of human disease
|
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McHugh, Kirk
|
The research efforts in my laboratory rely upon an integrated scientific approach that is designed to identify the genetic pathways responsible for the ontogenesis and pathogenesis of smooth muscle tissues. The dysregulation of smooth muscle differentiation represe. |
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Mehta,
Kamal D.
|
Signaling
and transcriptional mechanisms regulating cholesterol homeostasis
|
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Meier,
Iris
|
Molecular
analysis of the plant nuclear matrix
|
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Munson, Robert
|
Molecular
pathogenesis of Haemophilus infections
|
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Mykytyn, Kirk
|
Molecular genetics of complex diseases.
|
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Needham, Glen
|
Characterization
of tick salivary protein (calresticulin) and its role in tick
feeding/disease transmission.
|
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Niewiesk, Stefan
|
Immune modulation by measles virus and vaccination in the presence of maternal antibodies.
|
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Nishijima, Ichiko
|
Identify and characterize the genetic factors causing human developmental disorders.
|
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Oakley,
Berl
|
Microtubules;
mitosis; gamma-tubulin function
|
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Oberdick,
John
|
Genetic
control of mammalian brain development
|
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Obrietan, Karl
|
Second messenger signaling and transcriptional pathways that regulate circadian timing: Ca2+, CREB and neuronal plasticity: peptidergic modulation of glutamatergic signaling
|
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Oglesbee,
Michael
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Role
of cellular stress response/heat shock proteins in viral infection
(measles, canine distemper virus).
|
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Osmani,
Stephen A.
|
Cell
cycle; nuclear migration; fungal development
|
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Ostrowski,
Michael
|
Nonnuclear
oncogenes, ETS-family transcription factors, and the regulation of
transcription during cellular differentiation and malignant
transformation
|
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Otoshi, Akihira
|
Understand how gene function specifies cell types to generate and maintain neuronal tissues.
|
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Park,
Hay-Oak
|
Oriented
cell division; ras-like small GTPase; GTPase-activating protein;
cell-cycle control of polarity establishment in budding yeast
|
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Parris,
Deborah |
Herpes
simplex virus; gene expression and DNA replication |
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Partida-Sanchez, Santiago |
Chemokine receptor signaling, generation of calcium second messengers, activation of calcium channels
and their role in regulating migration of immune cells.
|
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Parthun,
Mark
|
The
role of histone posttranslational modifications in the formation and
regulation of chromatin
|
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Periasamy, Muthu
|
Genomics
and proteomics of the heart
|
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Perrotti, Danilo
|
Research is aimed at assessing the molecular mechanisms leading to leukemic transformation of hematopoietic
cells. Specific areas of interest are: a)Role of RNA binding proteins in blastic transformation of Chronic
Myelogenous Leukemia; b) Signal transduction in Leukemia; c) Mechanisms regulating expression and activity
of oncogenic kinases.
|
|
Phiel, Christopher
|
Understanding the functional role of GSK-3a, a kinase which regulates a number of signal
transduction pathways. Pursuing the mechanisms by which the amyloid peptides involved in Alzheimer's
disease are differentially regulated by GSK-3a and the closely related GSK-3b.
|
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Plass, Christoph
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Genomic
imprinting; DNA methylation and cancer
|
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Popovich, Phillip
|
Neuron-immune interactions in models of CNS trauma, spinal cord injury; mechanisms of neuronal and glial toxicity
triggered by innate and adaptive immune system; role of neuroinflammatory processes in glial tumor formation/progression.
|
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Rafael-Fortney, Jill
|
Mouse
models of neuromuscular diseases
|
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Rikihisa,
Yasuko
|
Molecular
and cellular mechanism of intracellular parasitism/Ehrlichia spp
|
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Robertson,Fredika
|
Role
of growth factors, adhesion molecules, and reactive intermediates in wound
healing and skin carcinogenesis
|
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Robinson,
John
|
Stimulatory
mechanisms in phagocytic leukocytes; endocytosis
|
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Rosol,
Thomas J.
|
The laboratory utilizes mouse models of human cancer to investigate the role of parathyroid hormone-related protein in bone metastasis and cancer-associated hypercalcemia. Metastases are monitored using in vivo bioluminescence of luciferase-transfected tumor cells. Molecular studies are focused on the regulation of PTHrP mRNA stability by transforming growth factor-s.
|
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Rotter, Andrej |
Bioinformatics
and computational biology of neural signaling molecules |
|
Rush, Laura |
Determine extent of aberrant methylation in human acute myeloid leukemia (AML) and
identify methylation targets that may play a role in leukemogenesis.
|
|
Sack,
Fred |
Molecular
genetics and cell biology of stomatal development; plant gravity sensing
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Saffen, David
|
Intracellular signaling in neuronal cells by muscarinic acetylcholine receptors, including the regulation of calcium influx, activation of protein kinases and induction of gene expression. Currently initiating a new line of research where we will attempt to identify genes that play a role in the therapeutic action of atypical antipsychotic drugs used in the treatment of schizophrenia.
|
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Sayre,
Richard
|
Photosynthesis;
metabolic engineering in plants; bioremediation
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Schmittgen, Thomas
|
Quantitative gene expression analysis, the role of small, noncoding (i.e. micro RNAs) in cancer.
|
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Schoenberg, Daniel
|
Regulation
of mRNAstability; pre-mRNA processing and translation initiation;
posttranscriptional control by estrogen
|
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Seeger,
Mark
|
Molecular
genetic analysis of axon pathfinding and synaptic target recognition
mechanisms in Drosophila.
|
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Sen, Chandan
|
Oxidants
and antioxidants in cell signaling; emphasis on DNA microarray, gene
transfer, wound healing, and neurodegeneration
|
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Sif, Said
|
Effects
of human chromatin remodeling complexes on gene expression, cell growth
and development
|
|
Simcox, Amanda
|
Analysis
of EGF-receptor signaling in Drosophila
|
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Snapka,
Robert
|
DNAreplication;
DNAtopoisomerases; mechanisms of anticancer drugs
|
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Somers,
David
|
Molecular
genetic analysis of the plant circadian clock
|
|
Strauch, Arthur
|
Myogenesis;
vascular cell biology; smooth-muscle actin gene expression
|
|
Suo, Zucai
|
Molecular
mechanisms of enzymes involved in genome replication and natural product
biosynthesis using a variety of techniques in enzymology, molecular
biology, and synthetic chemistry
|
|
Tabita,Robert
|
Molecular
biology and genetic engineering of CO2 metabolism
|
|
Toland, Amanda
|
Identification and characterization of low penetrance cancer susceptibility genes.
|
|
Trgovcich, Joanne
|
Research focuses on the discovery and characterization of strategies by which herpes simplex type 1 and cytomegalo viruses evade host immune responses. Towards this end, we are investigating (1) the biology of these ancient viruses at a molecular/genetic level, (2) the mechanisms by which viral gene products subvert cellular functions, and (3) the pathogenesis of these virus infections.
|
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Tridandapani, Susheela
|
My lab is primarily interested in dissecting the signal transduction processes involved in a) immune-complex clearance by macrophages, and the associated inflammation, and b) the inflammatory response to bacterial lipopolysaccharide.
|
|
Vaessin,
Harald
|
Neurogenesis;
neuronal precursor formation and differentiation in Drosophila
|
|
Vandré, Dale
|
Regulation
of the microtubule cytoskeleton during cell-cycle progression and in
Alzheimer's disease.
|
|
Verma,
Desh Pal
|
Vesicle
trafficking and building of cell plate during cytokinesis in plants
|
|
Waldman, James
|
Antiviral drug discovery and pre-clinical development, endothelium-targeted humoral autoimmune processes
in pulmonary disease and neuro-opthalmic disorders, chemical and biological reactivity of airborne nano-particulates
|
|
Weghorst,
Christopher
|
Molecular
mechanisms of human oral cancer; comparative molecular carcinogenesis;
chemoprevention strategies.
|
|
Weinstein,
Michael
|
Analysis
of mammalian development and disease using transgenic and knockout mouse
models
|
|
Williams, Marshall
|
DNA
replication and repair in eukaryotic cells and herpes viruses
|
Wilson, Thomas
|
My laboratory investigates the molecular biology and genetics of juvenile hormone in Drosophila. This hormone is a major player in insect development, metamorphosis, and reproduction, and we are studying how the hormone works at the molecular level.
|
|
Wu, Lai-Chu
|
V(D)J
recombination; protein binding to recombination signal sequences
|
|
Yoon,
Sung OK
|
Cell
signaling; neuronal apoptosis; transgenic mice; myelination; role of small
GTPases in brain development; nerve injury
|
|
Young, Tony
|
Regulation
of gene expression in the CNS, with an emphasis on Glutamine synthetase
and nitric oxide synthase - their roles in excitotoxic neuronal cell
death.
|
|
Yu, Chack-Yung
|
Molecular
biology of the human major histocompatibility complex class III products
and eukocyte antigen CD1.
|
|
Zhu, Mike
|
Molecular
biology and functional analysis of TRP and store-operated calcium
channels
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