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Research Articles : Sugimoto Y., Sawant D. B., Fisk H. A., Mao L., Li C., Chettiar S., Li P. K., Darby M. V., Brueggemeier R. W. (2017) Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorg. Med. Chem. 25:2156-66. Download or Link to Abstract at PubMed Marquardt, J. R., Perkins, J. L., Beuoy, K. J., and Fisk, H. A. (2016) Modular elements of the TPR domain in the Mps1 N-terminus differentially target Mps1 to the centrosome and kinetochore. Proc. Natt. Acad.Sci. USA 113:7828-33. Download or Link to Abstract at PubMed Sawant, D. B., Majumder, S., Perkins, J. L., Yang, C.-H., Eyers, P. A., and Fisk, H. A. (2015) Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes Centrin 2 function. Mol. Biol. Cell, 26:3741-53. Download or Link to Abstract at PubMed Majumder, S., Cash, A., and Fisk, H. A. (2015) Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis. Cells 4:331. Download or Link to Article at Cells Majumder S., and Fisk H. A. (2014) Quantitative Immunofluorescence Assay to Measure the Variation in Protein Levels at Centrosomes. J. Vis. Exp. 94:e52030. Link to Article and Video at JoVE. Majumder S., and Fisk H. A. (2013) VDAC3 and Mps1 negatively regulate ciliogenesis. Cell Cycle 12(5):849. Download or Link to abstract at Cell Cycle Majumder S., Slabodnick M., Pike A., Marquardt J., Fisk H. A. (2012) VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes. Cell Cycle 11(19):3666. Download or Link to abstract at Cell Cycle Mishra, A., Liu, S., Sams, G. H., Curphey, D. P., Santhanam, R., Rush, L. J., Schaefer, D., Falkenberg, L. G., Sullivan, L., Jaroncyk, L. Zou, X., Fisk, H., Labanowska, J., Caserta, E., Wu, L.-C., Becker, H., Chandler, J. C., Wu, Y.-Z., Heerema, N. A., Chan, K. K., Zhang, J., Porcu, P., Racke, F. K., Garzon, R., Lee, R. J., Marcucci G., and Caligiuri, M. A. (2012) Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation. Cancer Cell 22(5):645. Link to absract at Cancer Cell Liu J., Cheng X., Zhang Y., Li S., Cui H., Zhang L., Shi R., Zhao Z., He C., Wang C., Zhao H., Zhang C., Fisk H. A., Guadagno T. M., and Cui Y. (2012) Phosphorylation of Mps1 by BRAF(V600E) prevents Mps1 degradation and contributes to chromosome instability in melanoma. Oncogene 32(6):713. ePub Mar 19 2012. Link to abstract at Oncogene Liu, C., van Dyk, D., Choe, V., Yan, J., Majumder, S., Costanzo, M., Bao, X., Boone, C., Huo, K., Winey, M., Fisk, H. A, Andrews, B., and Rao, H. (2011) Ubiquitin Ligase Ufd2 Is Required For Efficient Degradation Of Mps1 Kinase. J Biol. Chem. 286(51): 43660. Link to abstract at JBC. Pike, A. N. and Fisk, H. A. Centriole assembly and the role of Mps1: defensible or dispensable? Cell Div, 2011. (14(6):9. Download or Link to manuscript at Cell Div Yang, C.-H., Kasbek, C., Majumder, S., Mohd Yusof, A., and Fisk, H. A. Mps1 Phosphorylation Sites Regulate the Function of Centrin2 in Centriole Assembly. Mol Biol Cell, 2010. 21(24):4361-72. Download or Link to manuscript at MBoC Kasbek, C., Yang, C.-H., and Fisk, H. A. Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes. Mol Biol Cell, 2010. 21(22):3878-89. Download or Link to manuscrip at MBoC Kasbek, C., Yang, C.-H., and Fisk, H. A. Mps1 as a link between centrosomes and genomic instability. Env Mol Mutagenesis, 2009. 50:654-665. Download or link to abstract at EMM Kasbek, C., Yang, C.-H., Yusof, A.-M., Chapman, H. M., Winey, M., and H. A. Fisk, Preventing the Degradation of Mps1 at Centrosomes is Sufficient to Cause Centrosome Re-duplication in Human Cells. Mol Biol Cell, 2007. 18: 4457-69. Download or link to manuscript at MBoC Fisk, H.A., C.P. Mattison, and M. Winey, Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression. Proc Natl Acad Sci U S A, 2003. 100 (25): 14875-80. Download or link to manuscript at PNAS Fisk, H.A. and M. Winey, The mouse mps1p-like kinase regulates centrosome duplication. Cell, 2001. 106 (1): 95-104. Download
Reviews and Book Chapters: Fisk, H. A., Mattison, C. P., and Winey, M. (2002). Centrosomes and Tumor Suppressors. Curr Op Cell Biol 14: 700-705. Fisk, H. A., Mattison, C. P., and Winey, M. (2002). Centrosomes and Tumor Suppressors. Curr Op Cell Biol 14: 700-705. Fisk, H. A., Mattison, C. P., and Winey, M. (2004). A Field Guide to the Mps1 Protein Kinases. Cell Cycle3(4) 439-442. Fisk, H. A.* and Winey, M. (2004) Mps1 flies into new areas. Current Biology14(24):R1058-60. Yang, C.-H., Kasbek, C., and Fisk, H. A. (2009) The use of infrared fluorescent dyes in quantitative immunoblotting. in Protein Protocols Handbook, Third Edition. Humana Press, London. Kasbek, C., Yang, C.-H., and Fisk, H. A. (2009) The use of infrared fluorescent dyes in immunofluorescence microscopy. in Protein Protocols Handbook, Third Edition. Humana Press, London. Fisk, H. A. (2011) The Mip-ing link; Mip1 links Mps1 to the actin cytoskeleton. Cell Cycle10(7):1031. Fisk, H. A. (2012) Many pathways to destruction: the centrosome and its control by and role in regulated proteolysis. in Centrosomes, H. Schatten Ed., Humana Press. Fisk, H.A. (2015) The Discovery of the Mitotic Spindle Assembly Checkpoint. Nature Education 8:8. Marquardt, J. R., and Fisk, H.A. (2016) AHRGEF17 sets the timer for retention of Mps1 at kinetochores. J. Cell Biol. 212:615-6.
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