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Bochemical
Community
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The faculty in the Department of Biochemistry represent a
part of a larger "Biochemical Community" here at The
Ohio State University. Thus, they and their research groups
have many excellent opportunities to interact, collaborate,
and socialize with other biochemists on a daily basis. Most
of these individuals have their primary appointments in the
Department of Molecular and Cellular Biochemistry (in the College
of Medicine) and the Department of Chemistry (in the College
of Mathematics and Physcial Sciences). Some of these faculty
members are listed below along with their research interests. |
Charles E. Bell, Department of
Molecular and Cellular Biochemistry. Structural
biology of homologous recombination, an important mechanism
in all cells for repairing double-stranded DNA breaks.
Arthur Burghes, Department of Molecular
and Cellular Biochemistry. The molecular understanding
of genetic neuromuscular disorders including the molecular
biology of Spinal Muscular Atrophy (SMA).
Robert Coleman, Department of Chemistry. Study
of naturally occurring antitumor agents such as azinomycins
A and B, and other toxic natural products such as schiarisanrins
A-D.
James Cowan, Department of Chemistry. Elucidation
of the critical roles of metal ions in biology with a focus
on some of the most important problems in bioinorganic chemistry.
Of particular interest is the chemistry of cellular iron,
the proteins that transport, store, and use iron in redox
and catalytic roles.
Ross Dalbey, Department of Chemistry. Determination
of how proteins are transported and inserted into membranes
to obtain their membrane topology.
Tsonwin Hai, Department of Molecular
and Cellular Biochemistry. Cancer and many diseases
are manifestations of over expression or under expression
of a gene or a group of genes, specifically through the
study of the mammalian ATF/CREB family of transcription
factors.
Russ Hille, Department of Molecular
and Cellular Biochemistry. Reaction mechanisms of
oxidoreductase enzymes - particularly those possessing
molybdenum or flavin in their active sites - and biological
electron transfer.
Samson Jacob, Department of Molecular
and Cellular Biochemistry. Study of metallothionein
gene expression and the molecular mechanisms by which
DNA methylation silences genes, particularly tumor suppressor
genes.
Jeff Kuret, Department of Molecular
and Cellular Biochemistry. Investigation of pathogenic
pathways that lead to the appearance of granulovacuolar
and neurofibrillary lesions found in Alzheimer's Disease
andother dementias.
Jiyan Ma, Department of Molecular
and Cellular Biochemistry. The study of Transmissible
Spongiform Encephalopathies (TSEs), also known as prion
disease.
Kamal D. Mehta, Department of Molecular
and Cellular Biochemistry. Investigation of the signaling
cascades and the mechanisms regulating transcription of
lipoprotein receptors involved in the pathogenesis of
cardiovascular diseases.
Mark R. Parthun, Department of Molecular
and Cellular Biochemistry. the study of the in
vivo role of the type B histone acetyltransferases
in the regulation of chromatin structure/function.
Dehau Pei, Department of Chemistry. Chemistry
and biology of posttranslational modifications of proteins.
Molecular mechanism by which proteins interact with each
other in cellular processes. Mechanism of bacterial cell-cell
communication (quorum sensing).
Douglas Pfeiffer, Department of Molecular
and Cellular Biochemistry. Research focuses on the
areas of bioenergetics, transport, and membrane biophysics.
Jill Rafael-Fortney, Department of
Molecular and Cellular Biochemistry. Research interests
are focused on the pathogenesis of neuromuscular diseases,
including Duchenne muscular dystrophy.
Saïd Sif, Department of Molecular
and Cellular Biochemistry. The study of transcription
factor interactions with DNA in a chromatin context, and
the examination of the effects of the Brg1 and hBrm-based
humanSWI/SNF chromatin remodeling complexes on nucleosomal
DNA.
Sean Taylor, Department of Chemistry. Research
focuses on the overlapping areas of mechanistic enzymology
and enzyme engineering/evolution especially utilizing the
tools of bioorganic chemistry and biology.
Claudia Turro, Department of Chemistry. Study
of the reactions of metal complexes that can be initiated
with light, both as potential antitumor agents and for the
fundamental understanding of reaction mechanisms and excited
states.
Pal L. Vaghy , Department of Molecular
and Cellular Biochemistry. The identification and
characterization of autocrine and paracrine signaling
mechanisms in skeletal muscle.
Scott Walsh, Department of Molecular
and Cellular Biochemistry. The understanding of the
roles of structure, dynamics and energetics in molecular
recognition among different classes of cytokines and their
receptors.
Lai Chu Wu, Department of Molecular
and Cellular Biochemistry. Mechanism of somatic V(D)J
recombination.
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