OSU Navigation Bar

The Ohio State University

Biochemistry

<empty>
HOME ACADEMICS RESEARCH PEOPLE SEMINARS NEWS   <empty> <empty>
 
Biochemistry Faculty

Jennifer J. Ottesen


Dr. Ottesen
Assistant Professor

Phone:  614-292-4525
Fax:      614-292-6773
email:  ottesen.1@osu.edu
Webpage: Ottesen Research Group Homepage



Research Interests:

Research in the Ottesen laboratory utilizes peptide and protein chemistry to address biological problems. The Ottesen group is developing improved techniques for solid phase chemical ligation, which allows the rapid recombination of peptide elements into larger macromolecules. They also employ expressed protein ligation, in which synthetic polypeptides and recombinant protein elements can be chemoselectively linked together. This allows the power of synthetic techniques to be applied to large proteins.



Selected publications from the last several years:

Ottesen, J.J., Bar-Dagan, M., Giovani, B., Muir, T.W.  (2008) "An amalgamation of solid phase peptide synthesis and ribosomal peptide synthesis." Biopolymers 90(3):406-14.

Ottesen, J.J., Huse, M., Sekedat, M.D., Muir, T.W.  (2004) "Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase." Biochemistry 43(19), 5698-706.

Cowburn, D., Shekhtman, A., Xu, R., Ottesen, J.J., Muir, T.W.  (2004) "Segmental isotopic labeling for structural biological applications of NMR." Methods Mol Biol. 278, 47-56.

Wilson, K.A., Kalkum, M., Ottesen, J.J., Yuzenkova, J., Chait, B.T., Landick, R., Muir, T., Severinov, K. and Darst, S.A.  (2004) "Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail." J. Am Chem. Soc. 125(41), 12475-83.

Ottesen, J.J., Blaschke, U.K. Cowburn, D. and Muir, T.W. (2003) "Segmental isotopic labeling:  Prospects for a new tool to study the structure-function relationships in multi-domain proteins."  Biol. Mag. Res. 20, 35-51.

Mezo, A.R., Ottesen, J.J., and Imperiali B.  (2001) " Discovery and characterization of a discretely folded homotrimeric betabetaalpha peptide." J. Am. Chem. Soc. 123(5), 1002-3.

Ottesen, J.J. and Imperiali, B.  (2001) " Design of a discretely folded mini-protein motif with predominantly beta-structure." Nat. Struct. Biol.8(6), 535-9.

Imperiali, B. and Ottesen, J.J.  (1999) "Uniquely folded mini-protein motifs." J. Pept. Res. 54(3), 177-84. (Review)

Imperiali, B. and Ottesen, J.J.  (1998) "Design strategies for the construction of independently folded polypeptide motifs." Biopolymers 47(1), 23-9.

Struthers, M., Ottesen, J.J.and Imperiali B.  (1998) "Design and NMR analyses of compact, independently folded BBA motifs." Fold Des. 3(2), 95-103.

<empty>
 
The Ohio State University, Department of Biochemistry Home | Academics | Research | People | Seminars | News
The Ohio State University - Department of Biochemistry
776 Biological Sciences Building, 484 West 12th Avenue
Columbus, Ohio 43210
TEL: 614.292.6771
FAX: 614.292.6773
<empty>