**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****
MSDS Name: Tris Borate EDTA 10X Powder
Catalog Numbers:
BP1334 1, BP1334-1, BP13341
Synonyms:
Tris-Boric Acid-ETDA Powder, TBE Powder
Company Identification: Fisher Scientific
1 Reagent Lane
Fairlawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS#
|
Chemical Name
| % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 60-00-4 |Ethylenediamine
tetraacetic acid | 3.5
| 200-449-4 |
|----------------|--------------------------------------|----------|-----------|
| 77-86-1 |Tris (hydroxymethyl)
aminomethane | 64
| 201-064-4 |
|----------------|--------------------------------------|----------|-----------|
| 10043-35-3 |Boric acid
| 32.5 | 233-139-2 |
+----------------+--------------------------------------+----------+-----------+
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Appearance: white.
Caution! May cause kidney damage. May cause central nervous system
effects. May cause reproductive effects based upon animal studies.
May cause eye and skin irritation. May cause respiratory and
digestive tract irritation.
Target Organs: Kidneys, central nervous system.
Potential Health Effects
Eye:
May cause eye
irritation.
Skin:
May cause skin
irritation.
Ingestion:
May cause irritation
of the digestive tract. May cause kidney
damage. May cause
central nervous system effects.
Inhalation:
May cause respiratory
tract irritation.
Chronic:
May cause borism
characterized by dry skin, skin eruptions, and
gastric disturbances..
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Immediately flush
eyes with plenty of water for at least 15 minutes,
occasionally lifting
the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical aid
if irritation develops or persists. Flush skin with
plenty of soap
and water.
Ingestion:
If victim is conscious
and alert, give 2-4 cupfuls of milk or water.
Never give anything
by mouth to an unconscious person. Get medical
aid immediately.
Inhalation:
Remove from exposure
to fresh air immediately. If not breathing,
give artificial
respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician:
Treat symptomatically
and
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire,
wear a self-contained breathing apparatus in
pressure-demand,
MSHA/NIOSH (approved or equivalent), and full
protective gear.
During a fire, irritating and highly toxic gases
may be generated
by thermal decomposition or combustion.
Extinguishing Media:
Substance is noncombustible;
use agent most appropriate to
extinguish surrounding
fire.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective
equipment as indicated
in Section 8.
Spills/Leaks:
Sweep up or absorb
material, then place into a suitable clean, dry,
closed container
for disposal. Avoid generating dusty conditions.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly
after handling. Use with adequate ventilation.
Minimize dust
generation and accumulation. Avoid contact with eyes,
skin, and clothing.
Keep container tightly closed. Avoid ingestion
and inhalation.
Storage:
Store in a tightly
closed container. Store in a cool, dry,
well-ventilated
area away from incompatible substances. Keep
containers tightly
closed.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use adequate ventilation
to keep airborne concentrations low.
Exposure Limits
+--------------------+-------------------+-------------------+-----------------+
| Chemical Name |
ACGIH |
NIOSH |OSHA - Final PELs|
|--------------------|-------------------|-------------------|-----------------|
| Ethylenediamine tet|none listed
|none listed |none listed
|
| raacetic acid |
|
|
|
|--------------------|-------------------|-------------------|-----------------|
| Tris (hydroxymethyl|none listed
|none listed |none listed
|
| ) aminomethane |
|
|
|
|--------------------|-------------------|-------------------|-----------------|
| Boric acid |none
listed |none listed
|none listed |
+--------------------+-------------------+-------------------+-----------------+
OSHA Vacated PELs:
Ethylenediamine
tetraacetic acid:
No OSHA Vacated PELs are listed for this chemical.
Tris (hydroxymethyl)
aminomethane:
No OSHA Vacated PELs are listed for this chemical.
Boric acid:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR
1910.134 or European Standard EN 149. Always use a
NIOSH or European Standard EN 149 approved respirator
when necessary.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State:
Solid
Appearance:
white
Odor:
odorless
pH:
Not available.
Vapor Pressure:
Not available.
Vapor Density:
Not available.
Evaporation Rate:
Not available.
Viscosity:
Not available.
Boiling Point:
Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point:
Not applicable.
NFPA Rating:
Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.
Decomposition Temperature: Not available.
Solubility:
Soluble in water.
Specific Gravity/Density: Not available.
Molecular Formula:
Mixture
Molecular Weight:
0
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable at room
temperature in closed containers under normal storage
and handling conditions.
Decarboxylates above 150C.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
EDTA is incompatible
with: strong oxidizing agents, strong bases,
copper, copper
alloys, aluminum. Tris is incompatible with strong
oxidizing agents
and strong acids. Boric acid is incompatible with
acetic anhydride
and potassium. Forms borate salts with basic
compounds.
Hazardous Decomposition Products:
Carbon monoxide,
carbon dioxide, nitric oxide (NOx) and ammonia (NH3)
fumes.
Hazardous Polymerization: Has not been reported.
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 60-00-4:
AH4025000
CAS# 77-86-1:
TY2900000
CAS# 10043-35-3:
ED4550000
LD50/LC50:
CAS# 60-00-4:
Oral, mouse: LD50 = 30 mg/kg.
CAS# 77-86-1:
Oral, rat: LD50 = 5900 mg/kg.
CAS# 10043-35-3:
Oral, mouse: LD50 = 3450 mg/kg; Oral, rat: LD50 =
2660 mg/kg.
Carcinogenicity:
Ethylenediamine tetraacetic acid
-
Not listed by
ACGIH, IARC, NIOSH, NTP, or OSHA.
Tris (hydroxymethyl) aminomethane
-
Not listed by
ACGIH, IARC, NIOSH, NTP, or OSHA.
Boric acid -
Not listed by
ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology:
No information
available.
Teratogenicity:
EDTA: Embryo or
Fetus, Stunted fetus, oral-rat TDLo=7632mg/kg.
Specific Developmental
Abnormalities, Cardiovascular, Craniofacial,
Musculoskeletal,
Respiratory, and Urogenital, oral-rat
TDLo=7632mg/kg.
Boric Acid: Decreased fetal weight, oral rat 13.3
mg/kg/1D.
Reproductive Effects:
EDTA: Fertility,
Post-implantation mortality, oral-rat
TDLo=7632mg/kg.
Boric Acid: Maternal effects on ovaries and
fallopian tubes,
oral rat TDLo=45 g/kg 90 days. Paternal effects on
spermatogenesis,
oral rat TDLo=52 mg/kg. effects on testes, sperm
duct or epididymis,
oral rat TDLo=45 g/kg 90 days.
Neurotoxicity:
No information
available.
Mutagenicity:
EDTA: Cytogenetic
Analysis, intraperitoneal-mouse 50mmol/L. DNA
Inhibition: hamster
fibroblast 500ug/L, rabbit kidney 250umol/L.
Other Studies:
None.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
EDTA: Catfish
(tap water) 129ppm/96H.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Chemical waste generators must determine whether a discarded chemical
is classif
as a hazardous waste.
US EPA guidelines for the classification determination are listed
in 40 CFR Part
Additionally, waste generators must consult state and local hazardous
waste regu
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
**** SECTION 14 - TRANSPORT INFORMATION ****
US DOT
No information
available
Canadian TDG
No information
available.
**** SECTION 15 - REGULATORY INFORMATION ****
US FEDERAL
TSCA
CAS# 60-00-4 is
listed on the TSCA inventory.
CAS# 77-86-1 is
listed on the TSCA inventory.
CAS# 10043-35-3
is listed on the TSCA inventory.
Health & Safety Reporting
List
None of the chemicals
are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals
in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals
are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals
in this material have a SNUR under TSCA.
SARA
Section 302 (RQ)
CAS# 60-00-4:
final RQ = 5000 pounds (2270 kg)
Section 302 (TPQ)
None of the chemicals
in this product have a TPQ.
SARA Codes
CAS # 77-86-1:
acute.
CAS # 10043-35-3:
acute.
Section 313
No chemicals are
reportable under Section 313.
Clean Air Act:
This material
does not contain any hazardous air pollutants.
This material
does not contain any Class 1 Ozone depletors.
This material
does not contain any Class 2 Ozone depletors.
Clean Water Act:
CAS# 60-00-4 is
listed as a Hazardous Substance under the CWA.
None of the chemicals
in this product are listed as Priority
Pollutants under
the CWA.
None of the chemicals
in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the chemicals
in this product are considered highly hazardous
by OSHA.
STATE
Ethylenediamine tetraacetic ac can be found
on the following state
right to know lists: California, New Jersey,
Pennsylvania,
Massachusetts.
Tris (hydroxymethyl) aminomethane is not present
on state lists from
CA, PA, MN, MA, FL, or NJ.
Boric acid is not present on state lists from
CA, PA, MN, MA, FL, or
NJ.
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
Not available.
Risk Phrases:
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 60-00-4:
2
CAS# 77-86-1:
1
CAS# 10043-35-3:
1
United Kingdom Occupational Exposure Limits
Canada
CAS# 60-00-4 is
listed on Canada's DSL/NDSL List.
CAS# 77-86-1 is
listed on Canada's DSL/NDSL List.
CAS# 10043-35-3
is listed on Canada's DSL/NDSL List.
WHMIS: Not available.
CAS# 60-00-4 is
not listed on Canada's Ingredient Disclosure List.
CAS# 77-86-1 is
not listed on Canada's Ingredient Disclosure List.
CAS# 10043-35-3
is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 10043-35-3:
OEL-RUSSIA:STEL 10 mg/m3
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 3/24/1998 Revision #2 Date: 8/02/2000
The information above is believed to be accurate
and represents the best
information currently available to us. However,
we make no warranty of
merchantability or any other warranty, express
or implied, with respect to
such information, and we assume no liability
resulting from its use. Users
should make their own investigations to determine
the suitability of the
information for their particular purposes. In
no way shall the company be
liable for any claims, losses, or damages of
any third party or for lost
profits or any special, indirect, incidental,
consequential or exemplary
damages, howsoever arising, even if the company
has been advised of
the possibility of such damages.
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