**** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****
MSDS Name: Ethyl Methanesulfonate
Catalog Numbers:
AC205260000, AC205260100
Synonyms:
Ethyl ester methanesulfonic acid; ethylmethane
sulfonate; EMS.
Company Identification (Europe): Acros Organics N.V.
Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium
Company Identification (USA): Acros Organics
One Reagent Lane
Fairlawn, NJ 07410
For information in Europe, call:
0032(0) 14575211
For information in North America, call: 800-ACROS-01
For emergencies in Europe, call: 0032(0) 14575299
For emergencies in the US, call CHEMTREC: 800-424-9300
**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
| CAS#
|
Chemical Name
| % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 62-50-0 |Ethyl methanesulfonate
| ca.100 | 200-536-7 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols:
XN
Risk Phrases:
40
**** SECTION 3 - HAZARDS IDENTIFICATION ****
EMERGENCY OVERVIEW
Appearance: colourless.
Caution! May cause cancer based on animal studies. May cause
irritation by all exposure routes.
Target Organs: Kidneys, lungs.
Potential Health Effects
Eye:
May cause eye
irritation.
Skin:
May cause skin
irritation.
Ingestion:
May cause irritation
of the digestive tract.
Inhalation:
May cause respiratory
tract irritation.
Chronic:
May cause cancer
according to animal studies.
**** SECTION 4 - FIRST AID MEASURES ****
Eyes:
Flush eyes with
plenty of water for at least 15 minutes,
occasionally
lifting the upper and lower eyelids. Get medical aid
immediately.
Skin:
Get medical
aid. Flush skin with plenty of soap and water for at
least 15 minutes
while removing contaminated clothing and shoes. Wash
clothing before
reuse.
Ingestion:
If victim is
conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything
by mouth to an unconscious person. Get medical
aid immediately.
Inhalation:
Remove from
exposure to fresh air immediately. If not breathing,
give artificial
respiration. If breathing is difficult, give oxygen.
Get medical
aid.
Notes to Physician:
Treat symptomatically
and supportively.
Antidote:
None reported.
**** SECTION 5 - FIRE FIGHTING MEASURES ****
General Information:
As in any fire,
wear a self-contained breathing apparatus in
pressure-demand,
MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
Use agent most
appropriate to extinguish fire.
**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
General Information: Use proper personal protective
equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill
with inert material, (e.g., dry sand or earth), then
place into a
chemical waste container. Clean up spills immediately,
observing precautions
in the Protective Equipment section. Provide
ventilation.
**** SECTION 7 - HANDLING and STORAGE ****
Handling:
Wash thoroughly
after handling. Use with adequate ventilation.
Minimize dust
generation and accumulation. Avoid contact with eyes,
skin, and clothing.
Keep container tightly closed. Avoid ingestion
and inhalation.
Storage:
Store in a cool,
dry, well-ventilated area away from incompatible
substances.
Keep containers tightly closed.
**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
Engineering Controls:
Use adequate
ventilation to keep airborne concentrations low.
Exposure Limits
+--------------------+-------------------+-------------------+-----------------+
| Chemical Name |
ACGIH |
NIOSH |OSHA - Final PELs|
|--------------------|-------------------|-------------------|-----------------|
| Ethyl methanesulfon|none listed
|none listed |none listed
|
| ate
|
|
|
|
+--------------------+-------------------+-------------------+-----------------+
OSHA Vacated PELs:
Ethyl methanesulfonate:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR
1910.134 or European Standard EN 149. Always use a
NIOSH or European Standard EN 149 approved respirator
when necessary.
**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State:
Liquid
Appearance:
colourless
Odor:
Not available.
pH:
Not available.
Vapor Pressure:
0.328 mm Hg @ 25C
Vapor Density:
Not available.
Evaporation Rate:
Not available.
Viscosity:
Not available.
Boiling Point:
86 deg C
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point:
212 deg F ( 100.00 deg C)
NFPA Rating:
(est.) Health: ; Flammability: 0; Reactivity: 0
Explosion Limits, Lower: Not available.
Upper: Not available.
Decomposition Temperature:
Solubility:
Specific Gravity/Density: 1.167
Molecular Formula:
CH3SO3C2H5
Molecular Weight:
124.1142
**** SECTION 10 - STABILITY AND REACTIVITY ****
Chemical Stability:
Stable under
normal temperatures and pressures.
Conditions to Avoid:
Incompatible
materials.
Incompatibilities with Other Materials:
Strong oxidizing
agents, strong bases.
Hazardous Decomposition Products:
Carbon monoxide,
oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported
**** SECTION 11 - TOXICOLOGICAL INFORMATION ****
RTECS#:
CAS# 62-50-0:
PB2100000
LD50/LC50:
CAS# 62-50-0:
Oral, mouse: LD50 = 470 mg/kg.
Carcinogenicity:
Ethyl methanesulfonate -
California:
carcinogen - initial date 1/1/88
NTP: Suspect carcinogen
OSHA: Possible Select carcinogen
IARC: Group 2B carcinogen
Epidemiology:
No information
available.
Teratogenicity:
TDLo(Intraperitoneal,
Rat) = 300 mg/kg; Kidney Tumors. TDLo (Oral,
Rat) =1043 gm/kg.
TDLo (Intraperitoneal, Rat) = 100 mg/kg;
Transplacental
tumorigenesis.
Reproductive Effects:
Experimental
reproductive effector.
Neurotoxicity:
No information
available.
Mutagenicity:
No information
available.
Other Studies:
No data available.
**** SECTION 12 - ECOLOGICAL INFORMATION ****
Ecotoxicity:
Based on a Log
KOW=0.09, BCF of <1 was estimated for ethyl
methanesulfonate.
Environmental Fate:
If released
into moist soil, ethyl methanesulfonate is expected to
hydrolyze as
fast, if not faster, than in water. Due to the
reactivity of
this compound, mobility is expected to be extremely
limited. If
released to dry soil, this compound is expected to
volatilize fairly
rapidly. Based on a vapor pressure of 0.328 mmHg
@25 Celcius,
ethyl methanesulfonate would volatilize rapidly from
dry soil surfaces.
Physical/Chemical:
For chemical
hydrolysis in water @ 20 Celcius, the halflife of ethyl
methanesulfonate
is equal to 96 hours.
Other:
Not available.
**** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 62-50-0: waste number U119.
**** SECTION 14 - TRANSPORT INFORMATION ****
US DOT
No information
available
IMO
Not regulated
as a hazardous material.
IATA
Not regulated
as a hazardous material.
RID/ADR
Not regulated
as a hazardous material.
Canadian TDG
No information
available.
**** SECTION 15 - REGULATORY INFORMATION ****
US FEDERAL
TSCA
CAS# 62-50-0
is listed on the TSCA inventory.
Health & Safety Reporting
List
None of the
chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the
chemicals in this product are under a Chemical Test Rule.
Section 12b
CAS# 62-50-0:
export notification required - Section 5
TSCA Significant New Use
Rule
CAS# 62-50-0
is a chemical with a Significant New Use Rule.
SARA
Section 302 (RQ)
CAS# 62-50-0:
final RQ = 1 pound (0.454 kg)
Section 302 (TPQ)
None of the
chemicals in this product have a TPQ.
SARA Codes
CAS # 62-50-0:
chronic.
Section 313
No chemicals
are reportable under Section 313.
Clean Air Act:
This material
does not contain any hazardous air pollutants.
This material
does not contain any Class 1 Ozone depletors.
This material
does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the
chemicals in this product are listed as Hazardous
Substances under
the CWA.
None of the
chemicals in this product are listed as Priority
Pollutants under
the CWA.
None of the
chemicals in this product are listed as Toxic Pollutants
under the CWA.
OSHA:
None of the
chemicals in this product are considered highly hazardous
by OSHA.
STATE
Ethyl methanesulfonate can be found on the
following state right to
know lists: California, New Jersey, Florida,
Pennsylvania, Minnesota,
Massachusetts.
The following statement(s) is(are) made in
order to comply with
the California Safe Drinking Water Act:
WARNING: This product contains Ethyl methanesulfonate,
a chemical
known to the state of California to cause
cancer.
California No Significant Risk Level:
None of the chemicals in this product are
listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 40 Possible risks of irreversible effects.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 62-50-0:
No information available.
Canada
CAS# 62-50-0
is listed on Canada's DSL/NDSL List.
This product
has a WHMIS classification of D2A.
CAS# 62-50-0
is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 62-50-0:
OEL-FINLAND;Carcinogen
OEL-SWEDEN;Carcinogen
**** SECTION 16 - ADDITIONAL INFORMATION ****
MSDS Creation Date: 1/28/1999 Revision #0 Date: Original.
The information above is believed to be accurate
and represents the best
information currently available to us. However,
we make no warranty of
merchantability or any other warranty, express
or implied, with respect to
such information, and we assume no liability
resulting from its use. Users
should make their own investigations to determine
the suitability of the
information for their particular purposes.
In no way shall the company be
liable for any claims, losses, or damages
of any third party or for lost
profits or any special, indirect, incidental,
consequential or exemplary
damages, howsoever arising, even if the company
has been advised of
the possibility of such damages.