ETHIDIUM BROMIDE- JT BAKER
MSDS Number: E2410 --- Effective Date:
12/08/96
1. Product Identification
Synonyms: Homidium
bromide; dromilac; 3,8-diamino-5-ethyl-6-phenyl
phenanthridinium
bromide
CAS No.: 1239-45-8
Molecular Weight:
394.31
Chemical Formula:
C21H20BrN3
Product Codes:
J.T. Baker: 4007 Mallinckrodt: 7738
2. Composition/Information on Ingredients
Ingredient
CAS No Percent
Hazardous
---------------------------------------
------------ ------- ---------
Ethidium Bromide
1239-45-8 90 - 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
WARNING! MAY
BE HARMFUL IF SWALLOWED, INHALED OR ABSORBED
THROUGH SKIN.
MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY
TRACT.
J.T. Baker SAF-T-DATA(tm)
Ratings (Provided here for your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating:
3 - Severe (Life)
Flammability
Rating: 1 - Slight
Reactivity Rating:
1 - Slight
Contact Rating:
3 - Severe (Life)
Lab Protective
Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES
Storage Color
Code: Orange (General Storage)
-----------------------------------------------------------------------------------------------------------
Potential Health
Effects
----------------------------------
No specific health
hazard information on this compound was found. However, its
chemical structure
and those of other polycyclica suggest that the following
warnings are
appropriate.
Inhalation:
Moderate irritant.
May cause coughing or sneezing.
Ingestion:
The material
should be assumed to be at least moderately hazardous.
Gastrointestinal
upset with possible liver or kidney damage are suggested by the
compound's structure.
Skin Contact:
The material
should be assumed to be a moderate irritant as well as a dye.
Inflammation
and discoloration of the ski>
Transfer interrupted!
Eye Contact:
Possible irritant.
Ethidium bromide may be absorbed through eye tissues with
unknown results.
See Ingestion, above.
Chronic Exposure:
No information
found.
Aggravation of
Pre-existing Conditions:
No information
found.
4. First Aid Measures
Inhalation:
Remove to fresh
air. Get medical attention for any breathing difficulty.
Ingestion:
Induce vomiting
immediately as directed by medical personnel. Never give anything
by mouth to an
unconscious person. Get medical attention.
Skin Contact:
Immediately flush
skin with plenty of water for at least 15 minutes. Remove
contaminated
clothing and shoes. Wash clothing before reuse. Thoroughly clean
shoes before
reuse. Get medical attention if irritation develops.
Eye Contact:
Immediately flush
eyes with plenty of water for at least 15 minutes, lifting upper
and lower eyelids
occasionally. Get medical attention if irritation persists.
5. Fire Fighting Measures
Fire:
As with most
organic solids, fire is possible at elevated temperatures or by contact
with an ignition
source.
Explosion:
Not an explosion
hazard under normal conditions of storage and use, but fine dust
dispersed in
air in sufficient concentrations, and in the presence of an ignition
source is a potential
dust explosion hazard. Sensitive to static discharge.
Fire Extinguishing
Media:
Water spray,
dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event
of a fire, wear full protective clothing and NIOSH-approved
self-contained
breathing apparatus with full facepiece operated in the pressure
demand or other
positive pressure mode.
6. Accidental Release Measures
Remove all sources
of ignition. Ventilate area of leak or spill. Wear appropriate
personal protective
equipment as specified in Section 8. Spills: Clean up spills in a
manner that does
not disperse dust into the air. Use non-sparking tools and
equipment. Reduce
airborne dust and prevent scattering by moistening with
water. Pick up
spill for recovery or disposal and place in a closed container.
7. Handling and Storage
Avoid dust formation
and control ignition sources. Employ grounding, venting and
explosion relief
provisions in accord with accepted engineering practices in any
process capable
of generating dust and/or static electricity. Empty only into inert
or non-flammable
atmosphere. Emptying contents into a non-inert atmosphere
where flammable
vapors may be present could cause a flash fire or explosion due
to electrostatic
discharge. Containers of this material may be hazardous when
empty since they
retain product residues (dust, solids); observe all warnings and
precautions listed
for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure
Limits:
None established.
Ventilation System:
A system of local
and/or general exhaust is recommended to keep employee
exposures as
low as possible. Local exhaust ventilation is generally preferred
because it can
control the emissions of the contaminant at its source, preventing
dispersion of
it into the general work area. Please refer to the ACGIH document,
Industrial Ventilation,
A Manual of Recommended Practices, most recent edition, for
details.
Personal Respirators
(NIOSH Approved):
For conditions
of use where exposure to the dust or mist is apparent, a half-face
dust/mist respirator
may be worn. For emergencies or instances where the
exposure levels
are not known, use a full-face positive-pressure, air-supplied
respirator. WARNING:
Air-purifying respirators do not protect workers in
oxygen-deficient
atmospheres.
Skin Protection:
Wear protective
gloves and clean body-covering clothing.
Eye Protection:
Use chemical
safety goggles. Maintain eye wash fountain and quick-drench
facilities in
work area.
9. Physical and Chemical Properties
Appearance:
Dark red crystals.
Odor:
Odorless.
Solubility:
5 grams in 100
grams of water.
Specific Gravity:
No information
found.
pH:
No information
found.
% Volatiles by
volume @ 21C (70F):
0
Boiling Point:
Not applicable.
Melting Point:
238 - 240C (460
- 464F)
Vapor Density
(Air=1):
No information
found.
Vapor Pressure
(mm Hg):
No information
found.
Evaporation Rate
(BuAc=1):
No information
found.
10. Stability and Reactivity
Stability:
Stable under
ordinary conditions of use and storage.
Hazardous Decomposition
Products:
Toxic gases and
vapors may be released if involved in a fire.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizers.
Conditions to
Avoid:
Heat, flames,
ignition sources and incompatibles.
11. Toxicological Information
No LD50/LC50 information
found relating to normal routes of occupational
exposure. Investigated
as a tumorigen and mutagen.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient
Known Anticipated IARC Category
------------------------------------
----- ----------- -------------
Ethidium Bromide (1239-45-8)
No No
None
12. Ecological Information
Environmental
Fate:
Environmental
Toxicity:
No information
found.
13. Disposal Considerations
Whatever cannot
be saved for recovery or recycling should be managed in an
appropriate and
approved waste disposal facility. Processing, use or
contamination
of this product may change the waste management options. State
and local disposal
regulations may differ from federal disposal regulations. Dispose
of container
and unused contents in accordance with federal, state and local
requirements.
14. Transport Information
Not regulated.
15. Regulatory Information
--------\Chemical Inventory Status
- Part 1\---------------------------------
Ingredient
TSCA EC Japan Australia
-----------------------------------------------
---- --- ----- ---------
Ethidium Bromide (1239-45-8)
Exempt Yes No Yes
--------\Chemical Inventory Status
- Part 2\---------------------------------
--Canada--
Ingredient
Korea DSL NDSL Phil.
-----------------------------------------------
----- --- ---- -----
Ethidium Bromide (1239-45-8)
Yes No No Yes
--------\Federal, State & International
Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient
RQ TPQ List Chemical Catg.
-----------------------------------------
--- ----- ---- --------------
Ethidium Bromide (1239-45-8)
No No No
No
--------\Federal, State & International
Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient
CERCLA 261.33 8(d)
-----------------------------------------
------ ------ ------
Ethidium Bromide (1239-45-8)
No No
No
Chemical Weapons Convention: No
TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes
Chronic: No Fire: No Pressure: No
Reactivity: No
(Pure / Solid)
Australian Hazchem
Code: No information found.
Poison Schedule:
No information found.
WHMIS:
This MSDS has
been prepared according to the hazard criteria of the Controlled
Products Regulations
(CPR) and the MSDS contains all of the information required
by the CPR.
16. Other Information
NFPA Ratings: Health: 1 Flammability: 1 Reactivity: 0
Label Hazard Warning:
WARNING! MAY
BE HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH
SKIN. MAY CAUSE
IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
Label Precautions:
Avoid breathing
dust. Avoid contact with eyes, skin and clothing. Keep container
closed. Use with
adequate ventilation. Wash thoroughly after handling. INTENDED
FOR R & D
USE ONLY. NOT ON THE TSCA INVENTORY.
Label First Aid:
If swallowed,
induce vomiting immediately as directed by medical personnel. Never
give anything
by mouth to an unconscious person. If inhaled, remove to fresh air.
Get medical attention
for any breathing difficulty. In case of contact, immediately
flush eyes or
skin with plenty of water for at least 15 minutes. Get medical
attention if
irritation develops or persists.
Product Use:
Research and
Development Use Only.
Revision Information:
Pure. New 16
section MSDS format, all sections have been revised.
Disclaimer:
************************************************************************************************
Mallinckrodt
Baker, Inc. provides the information contained herein in good faith
but makes no
representation as to its comprehensiveness or accuracy. This
document is intended
only as a guide to the appropriate precautionary handling
of the material
by a properly trained person using this product. Individuals
receiving the
information must exercise their independent judgment in
determining its
appropriateness for a particular purpose. MALLINCKRODT
BAKER, INC. MAKES
NO REPRESENTATIONS OR WARRANTIES, EITHER
EXPRESS OR IMPLIED,
INCLUDING WITHOUT LIMITATION ANY WARRANTIES
OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE WITH
RESPECT TO THE
INFORMATION SET FORTH HEREIN OR THE PRODUCT TO
WHICH THE INFORMATION
REFERS. ACCORDINGLY, MALLINCKRODT BAKER,
INC. WILL NOT
BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF
OR RELIANCE UPON
THIS INFORMATION.
************************************************************************************************
Prepared by:
Strategic Services Division
Phone Number:
(314) 539-1600 (U.S.A.)