NIH/NHLBI
Research Grant R21 (HL091417-01)
01/01/08-12/31/09
PI: Barbara Rita Alevriadou
Mechanoregulation of Endothelial Mitochondrial Function.

Lay summary:
The goal of this project is to characterize the mitochondrial (dys)function in cultured coronary arterial endothelial cells exposed to either fluid shear stress or an in vitro protocol of ischemia/reperfusion and to test potential therapeutic strategies, such as mitochondria-targeted antioxidants, that may protect the coronary endothelium from reperfusion injury.