Alcon Laboratories Inc., Fort Worth TX
Research Grant
PI: Douglas R. Pfeiffer
Mitochondrial Dysfunction during Retinal Degeneration

Lay summary:
Nonsteriodal anti-inflammatory drugs (NSAIDs) have many applications in medicine, including their use topically to alleviate pain and inflammation in the eye. As a new phase of our collaborations with Alcon Laboratories we are investigating the potential of these compounds to promote mitochondrial dysfunction. The goal is to reveal particular members of the NSAIDs family which have a minimum potential to generate toxicity and attendant side effects in an ocular environment.