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   Mitochondrial Research Community Looses a Senior Member

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Name:
Gerald P. Brierley
Born:
August 14, 1931, Ogallala, Nebraska
Military Status:
U.S. Air Force, 1954-1956, Captain
Education:

University of Maryland 1949-53       B.S. Zoology
University of Maryland 1956-60       Ph.D. Biochemistry
       Minor in Chemistry and Physiology
University of Wisconsin 1960-1962 Post-doctoral with David E. Green

Positions Held:
1962-1964

Research Assistant Professor
Institute of Enzyme Research
University of Wisconsin

Research on role of lipid in mitochondrial electron transport reactions, oxidative phosphorylation, accumulation of Mg2+ and Ca2+ by heart mitochondria, and the association of glycolytic enzymes with the red blood cell membrane.
1964-1965

Assistant Professor
Department of Physiological Chemistry
The Ohio State University
1965-1969
Associate Professor
Department of Physiological Chemistry
The Ohio State University
1969-1995
Professor
Department of Physiological Chemistry/Medicinal Chemistry
        (departmental name change)
The Ohio State University
1995-2006
Professor Emeritus
Department of Molecular and Cellular Biochemistry
     (departmental name change)
1975-1976

Visiting Professor
University of South Carolina
Department of Biochemistry
Charleston, South Carolina
1980-1982
Acting Chairman
Department of Physiological Chemistry
The Ohio State University
1983-1995
Chairman
Department of Medical Biochemistry
     (departmental name change)
The Ohio State University
Honors:
  • Established Investigator, American Heart Association, 1964-1969
  • American Heart Association Ohio Affiliate Research Merit Award, 1991
Societies:
  • American Society of Biological Chemists
  • American Society for Cell Biology
  • Biophysical Society
  • American Heart Association, Basic Science Council
  • Central Ohio Heart Association, Board of Trustees (1980-1985)
  • International Society for Heart Research
Editorial Boards:
  • Archives of Biochemistry and Biophysics
  • Journal of Bioenergetics and Biomembranes
  • Molecular and Cellular Biochemistry
Study Sections:
  • Member, NIH Physical Biochemistry Study Section (1981-85)
  • Special Reviewer, Biochemistry Study Section
  • Central Ohio Heart Chapter – Research and Fellowship Committee, Chairman (1980-82)
  • American Heart Association, Ohio Affiliate Research Review Committee (1980-84)
  • American Heart Associate, Ohio Affiliate Research Committee, Chairman (1988-89)
  • American Heart Association, National Review Committee, Metabolism & Cell Biology (1990-93)
  • Special Reviewer – VA grant program
Graduate Students:
George Hunter
PhD
1968
MD, private practice
William Jacobus
PhD
1969

Professor, Department of Anatomy, Medical College of Ohio

                                                                           
Kathryn Scott
PhD
1969

Associate Professor, Physiological Chemistry
The Ohio State University

                                                                           
Koh Hwang
PhD
1971

Assistant Professor
University of Southern California
Department of Medicine

                                                                           
Charles Rafferty
PhD
1974

Electric Power Research Institute
Paola Alto, California

                                                                           
Janna Wehrle
PhD
1975

Assistant Professor
Johns Hopkins University

                                                                           
G-Y Shi
PhD
1980
Formosan National University
Marianne Jurkowitz
PhD
1982

The Ohio State University
Molecular and Cellular Biochemistry

                                                                           
Charlene M. Hohl
PhD
1982

Research Scientist
The Ohio State University

                                                                           
Timothy Geisbuhler
PhD
1983

Assistant Professor
University of Missouri

                                                                           
Michael Murphy
PhD
1983

Clinical Chemistry
Cincinnati, Ohio

                                                                           
W. Wenger
PhD
1984

Steward Pharmaceuticals
Wilmington, Delaware

                                                                           
Dorothy Wimsatt
PhD
1990
Grant Hospital, Columbus, Ohio
Kemal Baysal
PhD
1993

The Ohio State University
Medical Biochemistry

                                                                            
Post-doctorals:
Vincent Knight
1966-68
University of Cardiff, Wales
C. Thomas Settlemire
1966-68
Bowdoin College, Maine
Kathryn Scott Pyant
1969-71
The Ohio State University
Ruth Altschuld
1974-80
The Ohio State University
Edmundo Chavez
1976-77

Institute de Cardiologia
Mexico City

                                                                                   
Dennis W. Jung
1977-86
The Ohio State University
Marianne Jurkowitz
1983-84
The Ohio State University
Mindy Lambert
1984-86
The Ohio State University
Michael Davis
1986-88

Environmental Testing
Marion, Ohio

                                                                                   
Tatyana Gudz
1989-91

Case Western Reserve University
Cleveland, Ohio

                                                                                   
Sergia Novgorodov
1989-91
Moscow State University, Russia
Unpublished Presentations:
  • Gordon Conference on Energy Coupling Mechanisms, 1966, 1971.
  • Princeton Research Conference, 1968
  • American Physiological Society Refresher Course on Bioenergetics, 1969
  • Biophysical Society Workshop on Bioenergetics, 1973
  • Mexican National University – Lecture Series, January, 1979
  • American Section of the International Society of Heart Research, Houston, May,  1985.
  • American Heart Association, Santa Fe, New Mexico, July 1989.
Consulting and Program Evaluations:
  • Program Review – University of Texas Graduate School of Biomedical Sciences, Galveston, 1977.
  • Program Review – University of Tennessee Graduate School – Medical Sciences, Memphis, 1978.
  • Review of Laboratory of Cardiovascular Science, National Institute on Aging, Gerontology Research Center, Baltimore, 1987.
RESEARCH PUBLICATIONS:

  1. Fleischer S, Klouwen H and Brierley GP. 1961.  Studies on the Electron Transfer System XXXVIII.  Lipid Composition of Purified Enzyme Preparations Derived from Beef Heart Mitochondria.  J Biol Chem 236:2936-2941.

  2. Fleischer S and Brierley GP.  1961.  Solubilization of Cholesterol in Phospholipid Micelles in Water.  Biochem Biophys Res Commun 5:367-372.

  3. Fleischer S and Brierley GP. 1961.  The Equilibration of Phospholipids between Soluble Micelles of Phospholipids and the Bound Lipid of Mitochondrial Particles.  Biochim Biophys Acta 53:609-612.

  4. Veitch, FP and Brierley GP.  1962.  The Quantitative Determination of Tartronic Acid (hydroxylmalonic Acid) in Urine and Tissues.  Biochim Biophys Acta 58:467-473.

  5. Brierley GP, and Merola AJ. 1962.  Studies of the Electron Transfer System XLVIII.  Phospholipid Requirements in Cytochrome Oxidase.  Biochim Biophys Acta 64:205-217.

  6. Brierley GP, Merola, AJ, and Fleischer S.  1962.  Studies of the Electron Transfer System XLVII.  Sites of Phospholipid Involvement in the Electron Transfer Chain.  Biochim Biophys Acta 64:218-228.

  7. Fleischer S, Brierley GP, Klouwen H and Slautterback DB.  1962.  Studies of the Electron Transfer System, XLVII.  The Role of Phospholipids in Electron Transfer.  J Biol Chem 237:3264-3272.

  8. Brierley GP, Bachmann E, and Green DE.  1962.  Active Transport of Inorganic Phosphate and Mg2+ by Heart Mitochondria.  Proc Natl Acad Sci US 48:1928-1935. [Abstract] [PDF]

  9. Brierley GP, Murer E and Green DE.  1963.  Participation of an Intermediate of Oxidative Phosphorylation in Ion Accumulation by Mitochondria.  Science 140:60-62.

  10. Brierley GP, Murer E, Bachmann E and Green DE.  1963.  Studies on Ion Transport II.  The Accumulation of Pi and Mg2+ by Heart Mitochondria.  J Biol Chem 238:3482-3489.

  11. Brierley GP, Murer E, and Bachmann E.  1964.  Studies on Ion Transport III.  The Accumulation of Ca2+ and Pi by Heart Mitochondria.  Arch Biochem Biophys 105:89-102.

  12. Brierley GP and Slautterback DB.  1964.  Studies on Ion Transport IV.  An Electron Microscope Study of the Accumulation of Ca2+ and Pi by Heart Mitochondria.  Biochim Biophys Acta 82:183-186.

  13. Brierley GP and Murer E.  1964.  Ion Accusation in Heart Mitochondria Supported by the Oxidation of Reduced Cytochrome c.  Biochem Biophys Res Communs 14:437-442.

  14. Brierley GP, Murer E and Bachmann E. 1964.  Studies on Ion Transport V.  Restoration of the ATP Supported Accumulation of Ca2+ in Aged Heart Mitochondria.  J Biol Chem 239:2706-2712.

  15. Brierley GP, Murer E and O’Brien RL. 1964.  Studies on Ion Transport VI.  Accumulation of Mg2+ by Heart Mitochondria in the Absence of Pi.  Biochim Biophys Acta 88:645-647.

  16. Brierley GP and Green. 1965.  Compartmentation of the Mitochondrion.  Proc Natl Acad Sci USA 53:73-79.

  17. Brierley, GP.  1965.  On the Efficiency of Oxidative Phosphorylation in Isolated Heart Mitochondria.  Biochem Biophys Res Communs 19:500-505.

  18. O’Brien RL and Brierley GP. 1965.  Compartmentation of Heart Mitochondria I.  Permeability of Isolated Beef Heart Mitochondria.  J Biol Chem 240:4527-4531.

  19. Brierley GP and O’Brien RL. 1965.  Compartmentation of Heart Mitochondria II.  Mitochondrial Adenine Nucleotides and the Action of Atractyloside. J Biol Chem 240:4532-4539.

  20. Green DE, Murer E, Hultin HO, Richardson SH, Salmon B, Brierley GP and Baum H.  1965.  Association of Integrated Metabolic Pathways with Membranes I.  Glycolytic Enzymes of the Red Blood Corpuscle and Yeast.  Arch Biochem Biophys 112:635-647.

  21. Brierley GP and Bhattacharyya RN.  1966.  Activation of Mg2+ Accumulation in Isolated Heart Mitochondria by Zn2+ and by p-chloromercuribezene sulfonate.  Biochem Biophys Res. Communs 23:647-651. [Abstract] [PDF]

  22. Brierley GP, Bhattacharyya RN and Walker JG. 1966.  Induction of K+ Transport in Heart Mitochondria by Zn2+.  Biochem Biophys Res Communs 24:269-273. [Abstract] [PDF]

  23. Brierley GP. 1967.  Ion Transport in Heart Mitochondria VII.  Activation of the Energy-Linked Accumulation of Mg2+ by Zn2+ and Other Cations.  J Biol Chem 242:1115-1121. [Abstract] [PDF]

  24. Brierley GP, Jacobus WE and Hunter GR.  1967.  Ion Transport in Heart Mitochondria VIII.  Activation of the ATP-Supported Accumulation of Mg2+ by Zn2+ and by p-Chloromercuribezene Sulfonate.  J Biol Chem 242:2192-2197. [Abstract] [PDF]

  25. Brierley GP, Settlemire CT and Knight VA.  1967.  Induction of K+ Transport and Swelling in Isolated Heart Mitochondria by Mercurial Compounds.  Biochem Biophys Res Communs 28:420-425. [Abstract] [PDF]

  26. Brierley GP and Settlemire CT.  1967.  Ion Transport by Heart Mitochondria IX.  Induction of Energy-Linked Uptake of K+ by Zn2+.  J Biol Chem 242:4324-4328. [Abstract] [PDF]

  27. Brierley GP and Knight VA.  1967.  Ion Transport by Heart Mitochondria X.  The Uptake and Release of Zn2+ and its Relation to the Energy-Linked Accumulation of Mg2+. Biochemistry 6:3892-3902.

  28. Brierley GP, Settlemire, CT and Knight VA.  1968.  Ion Transport by Heart Mitochondria XI.  The Spontaneous and Induced Permeability of Heart Mitochondria to Cations.  Arch Biochem Biophys 126:276-288. [Abstract] [PDF]

  29. Brierley GP, Knight VA and Settlemire CT.  1968.  Ion Transport by Heart Mitochondria XII.  Activation of Monovalent Cation Uptake by Sulfhydryl Group Reagents.  J Biol Chem 243:5025-5043. [Abstract] [PDF]

  30. Settlemire CT, Hunter GR and Brierley GP.  1968.  Ion Transport by Heart Mitochondria XIII.  The Effect of EDTA on Monovalent Ion Uptake.  Biochim Biophys Acta 162:487-499.

  31. Brierley GP, Fleischman D, Hughes SD, Hunter GR and McConnell DG.  1968.  On the Permeability of Isolated Bovine Retinal Outer Segment Fragments.  Biochim Biophys Acta 163:117-120.

  32. Knight VA, Settlemire CT and Brierley GP.  1968.  Differential Effects of Mercurial Reagents on Mitochondrial Thiol Groups and Mitochondrial Permeability.  Biochem Biophys Res Communs 33:287-293. [Abstract] [PDF]

  33. Hunter GR and Brierley GP.  1969.  Ion Transport by Heart Mitochondria XIV.  The Mannitol-Impermeable Compartment of the Mitochondrion and Its Relation to Ion Uptake.  Biochim Biophys Acta 180:68-80. [Abstract] [PDF]

  34. Hunter GR, Kamishima Y and Brierley GP.  1969.  Ion Transport by Heart Mitochondria XV.  Morphological Changes Associated with the Penetration of Solutes into Isolated Heart Mitochondria.  Biochim Biophys Acta 180:81-97. [Abstract] [PDF]

  35. Jacobus WE and Brierley GP.   1969.  Ion Transport by Heart Mitochondria XVI.  Cation Binding by Submitochondrial Particles.  J Biol Chem 244:4994-5004. [Abstract] [PDF]

  36. Brierley GP.  1969.  Energy-Linked Alteration of Mitochondrial Permeability to Anions.  Biochem Biophys Res Communs 35:396-402.

  37. Brierley GP. 1969.  The Effects of Zn2+ on the Permeability of Isolated Heart Mitochondria.  Ann NY Acad Sci 147:842-845.

  38. Brierley GP. 1970.  Ion Transport by Heart Mitochondria XVII.  Energy-Linked Alteration of the Permeability of Mitochondria to Cl- and other Anions.  Biochemistry 9:697-707. [Abstract] [PDF]

  39. Brierley GP and Stoner CT.  1970.  Ion Transport by Heart Mitochondria XVIII.  Swelling and Contraction of Heart Mitochondria Suspended in Ammonium Chloride.  Biochemistry 9:708-713.

  40. Scott KM, Knight VA, Settlemire CT and Brierley GP.  1970.  Ion Transport by Heart Mitochondria XIX.  Differential Effects of Mercurial Reagents on Membrane Thiols and on the Permeability of the Mitochondrion.  Biochemistry 9:714-724.

  41. Merola AJ and Brierley GP.  1970.  The Inhibition of Mitochondrial Oxidation and Uncoupling of Phosphorylation by Antispermatogenic Bis-dichloracetamides.  Biochem Pharmacol 19:1429-1442. [Abstract] [PDF]

  42. Brierley GP, Jurkowitz M, Scott KM and Merola AJ.  1970.  Ion Transport by Heart Mitochondria.  XX.  Factors Affecting Passive Osmotic Swelling of Isolated Mitochondria.  J Biol Chem 245:5404-5411. [Abstract] [PDF]

  43. Mezick JA, Settlemire, CT, Brierley GP, Barefield KKP, Jensen WN and Cornwell DG.  1970.  Erythrocyte Membrane Interactions with Menadione and the Mechanism of Menadione Induced Hemolysis.  Biochim Biophys Acta 219:361-371.

  44. Merola AJ and Brierley GP.  1970.  Respiratory Control Associated with Cyclic pH Transitions Induced by N, N1-Bis (Dichloroacetyl) 1, 12-Diaminododecane.  Biochem Biophys Res Communs 41:628-534.

  45. Cardona E, Lessler M and Brierley GP.  1971.  Mitochondrial Oxidative Phosphorylation:  Interaction of Pb2+ and Pi.  Proc Soc Exp Biol Med 136:300-304.

  46. Brierley GP, Jurkowitz M, Scott KM, Hwang KM and Merola AJ.  1971.  Activation of Energy-Linked K+ Accumulation in Isolated Heart Mitochondria by Non-Ionic Detergents.  Biochem Biophys Res Communs 43:50-57. [Abstract] [PDF]

  47. Merola AJ, Hwang KM, Jurkowitz M and Brierley GP.  1971.  Structural Requirements in the Uncoupling of Oxidative Phosphorylation by N, N1 Bis (Dichloroacetyl) Diamines.  Biochem Pharmacol 20:1393-1404. [Abstract] [PDF]

  48. Merola AJ, Scott KM and Brierley GP.  1971.  A Simple Large Volume Cell Suitable for Multiparameter Measurements in the Aminco Chance Spectrophotometer.  Anal Biochem 41:455-459.

  49. Brierley GP, Scott KM and Jurkowitz M.  1971.  Ion Transport by Heart Mitochondria XXI.  Differential Effects of Mercurial Reagents on ATPase Activity and on ATP-dependent Swelling and Contraction.  J Biol Chem 246:2241-2251. [Abstract] [PDF]

  50. Hunter GR and Brierley GP.  1971.  On the “Energized-Twisted” Configuration of Isolated Beef Heart Mitochondria.  J Cell Biol 50:250-255. [PDF]

  51. Brierley GP, Jurkowitz M, Scott KM, and Merola AJ.  1971.  Ion Transport by Heart Mitochondria XXII.  Spontaneous, Energy-Linked Accumulation of Acetate and Phosphate Salts of Monovalent Cations.  Arch Biochem Biophys 147:545-556.

  52. Scott KM, Hwang KM, Jurkowitz M. and Brierley GP. 1971.  Ion Transport by Heart Mitochondria XXIII.  The Effects of Lead on Mitochondrial Reactions.  Arch Biochem Biophys 147:557-567.

  53. Hwang KM, Scott KM and Brierley GP.  1972.  Ion Transport by Heart Mitochondria XXIV.  The Effects of Cu+2 on Membrane Permeability.  Arch Biochem Biophys 150:746-756.

  54. Farrell EC, Baba N, Brierley GP and Gruemer H-D.  1972.  On the Creatine Phosphokinase of Heart Muscle Mitochondria.  Laboratory Investigation 27:209-213.

  55. Brierley GP, Jurkowitz M, Merola AJ and Scott KM.  1972.  Ion Transport by Heart Mitochondria XXV.  Activation of Energy-Linked K+ Uptake by Non-Ionic Detergents.  Arch Biochem Biophys 152:744-754. [Abstract] [PDF]

  56. VanZutphen H, Merola AJ, Brierley GP and Cornwell DG. 1972.  The Interaction of Non-Ionic Detergents with Lipid Bilayer Membranes.  Arch Biochem Biophys 152:755-766. [Abstract] [PDF]

  57. Scott KM, Jurkowitz M and Brierley GP.  1972.  Ion Transport by Heart Mitochondria XXVI.  Carrier-Mediated, Anion Transport by Beef Heart Mitochondria.  Arch Biochem Biophys 153:682-694. [Abstract] [PDF]

  58. Brierley GP, Jurkowitz M, and Scott KM.  1973.  Ion Transport by Heart Mitochondrial XXVII.  Relation of Mercurial-Induced ATPase Activity to Ion Movements.  Arch Biochem Biophys 159:742-756. [Abstract] [PDF]

  59. Altschuld RA, Merola AJ and Brierley GP.  1975.  The Permeability of Heart Mitochondria to Creatine.  J Mol Cell Cardio 7:451-462. [Abstract] [PDF]

  60. Jurkowitz M, Scott KM, Altschuld RA, Merola AJ and Brierley GP. 1974.  Ion Transport by Heart Mitochondria XXVIII.  Retention and Loss of Energy-Coupling in Aged Heart Mitochondria.  Arch Biochem Biophys 165:98-113.

  61. Wehrle JP, Jurkowitz M, Scott KM and Brierley GP.  1976.  Mg2+ and the Permeability of Heart Mitochondria to Monovalent Cations.  Arch Biochem Biophys 174:312-323.

  62. Brierley GP and Jurkowitz M.  1976.  On the Mechanism of Energy-Dependent Contraction of Swollen Mitochondria.  Biochem Biophys Res Communs 68:82-88. [Abstract] [PDF]

  63. Altschuld RA and Brierley GP.  1977.  Interaction Between the Creatine Phosphokinase of Heart Mitochondria and Oxidative Phosphorylation.  J Mol and Cell Cardiol 9:875-896.

  64. Brierley GP, Jurkowitz M and Chavez E.  1977.  Energy-Dependent Contraction of Swollen Mitochondria-Activation by Nigericin.  Biochem Biophys Res Communs 74:235-241. [Abstract] [PDF]

  65. Chavez E, Jung DW and Brierley GP.  1977.  Energy-Dependent Efflux of K+ from Heart Mitochondria.  Biochem Biophys Res Communs 75:69-75. [Abstract] [PDF]

  66. Jung DW, Chavez E and Brierley GP.  1977.  Energy-Dependent Exchange of K+ in Heart Mitochondria.  Biochem Biophys Res Communs 75:69-75.

  67. Chavez E, Jung DW and Brierley GP.  1977.  Energy-Dependent Exchange of K+ in Heart Mitochondria II.  K+ Efflux.  Arch Biochem Biophys 183:460-470. [Abstract] [PDF]

  68. Brierley GP, Jurkowitz M, Chavez E and Jung DW. 1977.  Energy-Dependent Contraction of Swollen Heart Mitochondria.  J Biol Chem 252:7932-7939. [PDF]

  69. Brierley GP, Jurkowitz MS and Jung DW.  1978.  Osmotic Swelling of Heart Mitochondria in Acetate and Chloride Salts-Evidence for Two Pathways for Cation Uptake.  Arch Biochem Biophys 190:181-192. [Abstract] [PDF]

  70. Jung DW and Brierley GP.  1979.  Energy-Dependent Contraction of Swollen Heart Mitochondria-Activation by Butacaine.  Arch Biochem Biophys 193:76-87. [Abstract] [PDF]

  71. Jung DW and Brierley GP.  1979.  Swelling and Contraction of Potato Mitochondria.  Plant Physiol 64:948-953. [Abstract] [PDF]

  72. Jung DW, Shi G-Y and Brierley GP.  1980.  Dicyclohexylcarbodiimide Inhibits Monovalent Cation Influx but not Cation/H+ Exchange in Heart Mitochondria.  J Biol Chem 255:408-412.

  73. Shi G-Y, Jung DW and Brierley GP.  1980.  Induction of Na+/K+ Exchange in Swollen Heart Mitochondria.  J Bioenerget Biomembr 12:233-247. [Abstract]

  74. Altschuld RA, Gibb LA, Ansel AZ, Hohl C, Kruger FA and Brierley GP.  1980.  Calcium Tolerance of Isolated Rat Heart Cells.  J Mol Cell Cardiol 12:1383-1396.

  75. Dordick RS, Brierley GP, Garlid KD.  1980.  On the Mechanism of A23187-Induced K+ Efflux in Rat Liver Mitochondria.  J Biol Chem 255:10299-10395, [Abstract] [PDF]

  76. Shi G-Y, Jung DW, Garlid KD and Brierley GP.  1980.  Induction of Respiratory-Dependent Net Efflux of K+ from Heart Mitochondria by Depletion of Endogenous Divalent Cations.  J Biol Chem 255:10306-10311. [Abstract] [PDF]

  77. Jung DW and Brierley GP.  1981.  Progesterone Inhibits Cation Permeability but not Cation/H+ Exchange in Isolated Heart Mitochondria.  Experientia 37:237-238. [Abstract]

  78. Altschuld RA, Hohl C, Ansel A and Brierley GP. 1981.  Compartmentation of K+ in Isolated Adult Rat Heart Cells.  Arch Biochem Biophys 209:174-184.

  79. Altschuld RA, Hostetler JR and Brierley GP.  1981.  Response of Isolated Rat Heart Cells to Hypoxia, Re-Oxygenation, and Acidosis.  Circ Res 49:307-316. [Abstract]

  80. Jung DW, Shi G-Y and Brierley GP.  1981.  Induction of Passive Monovalent Cation Exchange Activity in Heart Mitochondria by Depletion of Endogenous Divalent Cations.  Arch Biochem Biophys 209:356-361.

  81. Jung DW and Brierley GP.  1981.  On the Relationship between Uncoupler-Induced Efflux of K+ and the Oxidation-Reduction State of Pyridine Nucleotides in Beef Heart Mitochondria.  J Biol Chem 256:10490-10496. [Abstract] [PDF]

  82. Unverferth DV, Leier CV, Brierley GP, Magorien RD and Baba N.  1981.  Human Myocardial Mitochondria:  Size Differences in Parts of the Cell.  Exp Mol Path 35:184-188.

  83. Hohl C, Ansel A, Altschuld A and Brierley GP 1982.  Contracture of Isolated Rat Heart Cells on Anaerobic to Aerobic Transition – A Cellular Model for Oxygen Paradox.  Am J Physiol 242:H1022-H1030. [Abstract] [PDF]

  84. Jurkowitz MS and Brierley GP.  1982.  H+ - Dependent Efflux of Ca2+ from Heart Mitochondria.  J Bioenerget Biomembr 14:435-449. [Abstract]

  85. Jung DW and Brierley GP.  1982.  Ruthenium Red Induced Loss of Matrix K+ from Uncoupled Heart Mitochondria.  Biochem Biophys Res Communs 105:432-438.

  86. Murphy MP, Hohl C, Brierley GP and Altschuld RA.  1982.  Release of Enzymes from Adult Rat Heart Myocytes.  Circ Res 51:560-568. [Abstract]

  87. Jung DW and Brierley GP.  1982.  The Redox State of Pyridine Nucleotides Controls Permeability of Uncoupled Mitochondria to K+.  Biochem Biophys Res Com 106:1372-1377.

  88. Pyant KS and Brierley GP.  1982.  Monovalent Cation Conductance in Liposomes Induced by Ionophore A23187.  Experientia 38:1202-1204. [Abstract]

  89. Hohl C, Altschuld RA, and Brierley GP.  1983.  Effects of Ca2+ on the Permeability of Adult Rat Heart Cells to Na+.  Arch Biochem Biophys 223:120-128. [Abstract] [PDF]

  90. Jurkowitz MS, Geisbuhler T, Jung DW and Brierley GP.  1983.  Ruthenium Red-Sensitive and Insensitive Pathways for the Release of Ca2+ from Uncoupled Heart Mitochondria.  Arch Biochem Biophys 223:120-128. [Abstract] [PDF]

  91. Jurkowitz MS, Altschuld RA, Brierley GP and Cragoe EJ, Jr.  1983.  Inhibition of Na+ - dependent Ca2+ Efflux from Heart Mitochondria by Amiloride Analogues.  FEBS Lett 163:262-265. [Abstract] [PDF]

  92. Geisbuhler T, Altschuld RA, Trewyn RW, Ansel AZ, Lamka K, and Brierley GP.  1984. Adenine Nucleotide Metabolism and Compartmentalization in Isolated Adult Rat Heart Cells.  Circ Res 54:536-546. [Abstract]

  93. Jung DW and Brierley GP.  1984.  The Permeability of Uncoupled Heart Mitochondria to K+.  J Biol Chem 259:6904-6911. [Abstract] [PDF]

  94. Jung DW, Farooqui T, Utz E and Brierley GP.  1984.  Effects of Quinine on K+ Transport in Heart Mitochondria.  J Bioenerget Biomembr 16:379-390. [Abstract]

  95. Brierley GP, Jurkowitz MS, Farooqui T and Jung DW.  1984.  K+/H+ Antiport in Heart Mitochondria.  J Biol Chem 259:14672-14678. [Abstract] [PDF]

  96. Altschuld RA, Hohl CM, Lamka KG and Brierley GP.  1984.  Effects of Amiloride on Ca2+ Uptake by Myocytes Isolated from Adult Rat Hearts.  Life Sci 35:865-870. [Abstract]

  97. Wenger WC, Murphy MP, Brierley GP and Altschuld RA.  1985.  Effects of Ionic Strength and Sulfhydryl Reagents on the Binding of Creatine Phosphokinase to Heart Mitochondrial Inner Membranes.  J Bioenerg Biomembr 17:295-303. [Abstract]

  98. Altschuld RA, Wenger WC, Lamka KG, Kindig OR, Capen CC, Mizuhira V, Vander Heide RS and Brierley GP.  1985.  Structural and Functional Properties of Adult Rat Heart Myocytes Lysed with Digitonin.  J Biol Chem 260:14325-14334. [Abstract] [PDF]

  99. Wenger WC, Murphy MP, Kindig OR, Capen CC, Brierley GP and Altschuld RA 1985.  Mitochondrial Enzyme Retention by Irreversibly Damaged Rectangular Isolated Adult Rat Heart Myocytes.  Life Sci 37:1697-1704. [Abstract]

  100. Lambert MR, Johnson JD, Lamka KG, Brierley GP and Altschuld RA.  1986.  Intracellular Free Ca2+ and the Hypercontracture of Adult Rat Heart Myocytes.  Arch Biochem Biophys 245:426-435. [Abstract]

  101. Jung DW and Brierley GP.  1986. Matrix Magnesium and the Permeability of Heart Mitochondria to K+.  J Biol Chem 261:6408-6415. [Abstract] [PDF]

  102. Brierley GP, Davis M and Jung DW.  1987.  Respiration-Dependent Uptake and Extrusion of Mg2+ by Isolated Heart Mitochondria.  Arch Biochem Biophys 253:322-332. [Abstract] [PDF]

  103. Davis MH, Jung DW and Brierley GP.  1987.  Inhibition of Na+/Ca2+ Antiport of Heart Mitochondria by Diethyl-pyrocarbonate.  J Bioenerg Biomem 19:515-524. [Abstract]

  104. Altschuld RA, Gamelin LM, Kelley RE, Lambert MR, Mackall LE and Brierley GP.   1987.  Degradation and Resynthesis of Adenine Nucleotides in Adult Rat Heart Myocytes.  J Biol Chem 262:13527-13533. [Abstract] [PDF]

  105. Davis MH, Altschuld RA, Jung DW and Brierley GP.  1987.  Estimation of Intramitochondrial pCa and pH by Fura-2 and BCECF Fluorescence.  Biochem Biophys Res Communs 149:40-45. [Abstract] [PDF]

  106. Brierley GP, Davis MH and Jung DW.  1988.  Respiration-Dependent Contraction of Swollen Heart Mitochondria:  Participation of the K+/H+ Antiporter.  J Bioenerget Biomemb 10:229-242. [Abstract]

  107. Brierley GP, Davis MH and Jung DW.  1988.  Intravesicular pH Changes in Submitochondrial Particles Induced by Monovalent Cations:  Relationship to the Na+/H+ and K+/K+ Antiporters.  Arch Biochem Biophys 264:417-427.

  108. Jung DW, Davis MH and Brierley GP.  1988.  Estimation of the pH Gradient and Donnan Potential in Deenergized Heart Mitochondria.  Arch Biochem Biophys 263:19-28. [Abstract]

  109. Brierley GP, Davis MH, Cragoe EG Jr and Jung DW.  1989.  Kinetic Properties of the Na+/H+ Antiport of Heart Mitochondria.  Biochemistry 28:4347-4354. [Abstract]

  110. Jung DW, Davis MH and Brierley GP.  1989.  Estimation of Matrix pH in Isolated Heart Mitochondria Using a Fluorescent Probe.  Anal Biochem 178:348-354. [Abstract]

  111. Hohl CM, Wimsatt DK, Brierley GP and Altschuld RA.  1989.  IMP Production of ATP-Depleted Adult Rat Heart Cells:  Effect of Glycolysis and a1-Adrenergic Stimulation.  Circ Res 65:754-760. [Abstract]

  112. Hohl CM, Wetzel S, Fertel RH, Wimsat DK, Brierley GP and Altschuld RA.  1989.  Hyperthyroid Adult Rat Cardiomyocytes:  I. Nucleotide Content, Beta and Alpha Adrenoreceptors and Cyclic AMP Production.  Am J Physiol 257:C948-C956. [Abstract] [PDF]

  113. Brierley GP and Jung DW.  1990.  Kinetic Properties of the K+/H+ Antiport of Heart Mitochondria.  Biochemistry 29:408-415. [Abstract]

  114. Timerman T, Altschuld RA, Hohl CM, Brierley GP and Merola AJ.  1990.  Cellular Glutathione and the Response of Adult Rat Heart Myocytes to Oxidant Stress.  J Mol Cell Cardiol 22:565-575. [Abstract]

  115. Jung DW, Apel L and Brierley GP.  1990.  Matrix Free Mg2+ Changes with Metabolic State in Isolated Heart Mitochondria.  Biochemistry 29:4121-4128. [Abstract]

  116. Wimsatt DK, Hohl CM, Brierley GP and Altschuld RA.  1990.  Calcium Accumulation and Release by the Sarcoplasmic Reticulum of Digitonin-Lysed Adult Mammalian Ventricular Cardiomyocytes.  J Biol Chem 265:14849-14857. [Abstract] [PDF]

  117. Brierley GP, Panzeter ES and Jung DW.  1991.  Regulation of Mitochondrial K+/H+ Antiport Activity by Hydrogen Ions.  Arch Biochem Biophys 288:358-367. [Abstract]

  118. Baysal K, Brierley GP, Novgorodov S and Jung DW.  1991.  Regulation of the Mitochondrial Na+/Ca2+ Antiport by Matrix pH.  Arch Biochem Biophys 291:383-389. [Abstract]

  119. Jung DW and Brierley GP.  1992.  Determination of free Mg2+ in Isolated Mitochondria using Fluorescent Probes.  Magnesium and Trace Elem 10:151-164. [Abstract]

  120. Jung DW and Brierley GP.  1992.  Transmembrane Gradients of Free Na+ in Isolated Heart Mitochondria Estimated using a Fluorescent Probe.  Am J Physiol 262:C1047-C10455.

  121. Novgorodov SA, Gudz TI, Jung DW and Brierley GP.  1991.  The Nonspecific Inner Membrane Pore of Liver Mitochondria:  Modulation of Cyclosporin Sensitivity by ADP at Carboxyatractyloside-Sensitive and Insensitive Sites.  Biochem Biophys Res Communs 180:33-38. **** [Abstract] [PDF]

  122. Altschuld RA, Hohl CM, Castillo LM, Garleb AA, Starling RC and Brierley GP.  1992.  Cyclosporine Inhibits Mitochondrial Ca2+ Efflux in Isolated Adult Ventricular Cardiomyocytes.  Am J Physiol 262:H1699-H1704. [Abstract] [PDF]

  123. Novgorodov SA, Gudz TI, Milgram YM and Brierley GP.  1992.  The Permeability Transition in Heart Mitochondria is Regulated Synergistically by ADP and Cyclosporin A.  J Biol Chem 267:16274-16282. [Abstract] [PDF]

  124. Mallery SR, Lantry LE, Laufman HB, Stephens RE, Brierley GP.  1993.  Modulation of Human Microvascular Endothelial Cell Bioenergetic Status and Glutathione Levels During Proliferative and Diffferentiated Growth.  J Cell Biochem 53:360-372. [Abstract]

  125. Altschuld RA, Jung DW, Phillips RM, Narayan P, Castillo LCC, Whitaker TE, Hensley J, Hohl CM and Brierley GP.  1994.  Evidence Against Norepinephrine Stimulated Efflux of Mitochondrial Mg2+ from Intact Cardiac Myocytes.  Am J Physiol 266:H1103-H1111. [Abstract] [PDF]

  126. Jung DW and Brierley GP.  1994.  Magnesium Transport by Mitochondria.  J Bioenerg Biomembr 26:527-535. [Abstract]

  127. Brierley GP, Baysal K and Jung DW.  1994.  Cation Transport Systems in Mitochondria: Na+ and K+ Uniports and Exchangers.  J Bioenerg Biomembr 26:519-526. [Abstract]

  128. Baysal K, Jung DW, Gunter KK, Gunter TE and Brierley GP.  1994.  The Na+-Dependent Ca2+ Efflux Mechanism of Heart Mitochondria is not a Passive Ca2+/2Na+ Exchanger.  Am J Physiol 266:C900-C808. [Abstract] [PDF]

  129. Mallery SR, Lantry LE, Hegtvedt AK, Lazo A, Titterington LC, Hout BL, Brierley GP and Stephens RE.  1994.  Environmental Induction of Tumor Phenotype in a Putative Kaposi Sarcoma Progenitor Cell.  Lymphology 27:45-48. [Abstract]

  130. Novgorodov SA, Gudz TI, Brierley BP. and Pfeiffer DR:  1994.  Magnesium Ion Modulates the Sensitivity of the Mitochondrial Permeability Transition Pore to Cyclosporin A and ADP.  Arch of Biochem and Biophys 311(2):219-228. [Abstract] [PDF]

  131. Mallery SR, Bailer RT, Hohl CM, Ng-Bautista CL, Ness GM, Livingston BE, Hout BL, Stephens RE and Brierley GP.  1995.  Cultured AIDS-related Kaposi’s Sarcoma (AIDS-KS) Cells Demonstrate Impaired Bioenergetic Adaptation to Oxidate Challenge:  Implication for Oxidant Stress in AIDS-KS Pathogenesis.  J Cell Biochem 59(3)317-28. [Abstract]

  132. Bailer RT, Lazo A, Ng-Bautista CL, Hout BL Ness GM, Hegtvedt AK, Lantry LE, Blakeslee JR, Stephens RE, Brierley GP and Mallery SR.  1995.    Correlation between AIDS-related Kaposi Sarcoma Histological Grade and in vitro Behavior:  Reduced Exogenous Growth Factor Requirements for Isolates from High Grade Lesions.  Lymphology 28:126-37. [Abstract]

  133. Bailer RT, Lazo A, Ng-Bautista CL, Hout BL, Ness GM, Hegtvedt AK, Blakeslee JR, Stephens RE, Brierley GP and Mallery SR. 1995.  Comparison of Constitutive Cytokine Release in High and Low Histologic Grade AIDS-related Kaposi’s Sarcoma Cell Strains and in Sera From HIB+/KSS+ and HIV+/KS- Patients.  J Interferon Cytokine Res 15:473-483. [Abstract]

  134. Jung DW, Baysal K and Brierley GP.  1995.  The Sodium-Calcium Antiport of Heart Mitochondria is Not Electroneutral.  J Biol Chem 270:672-678. [Abstract] [PDF]

  135. Mallery SR, Lantry LE, Toms MC, Titterington LC, Hout BL, Brierley GP and Stephens RE.  1995.  Human Microvascular Endothelial Cell-Extracellular Matrix Interaction in Cellular Growth State Determination.  Cell & Tissue Res 279(1):37-45, 1995. [Abstract]

  136. Jung DW, Chapman CJ, Baysal K, Pfeiffer DR and Brierley GP.  1996.  On the Use of Fluorescent Probes to Estimate Free Mg2+ in the Matrix of Heart Mitochondria.  Arch Biochem Biophys 332:19-29.  [Abstract] [PDF]

  137. Jung DW, Baysal K and Brierley GP.  1996.  Properties of the Na+-Ca2+ Antiport of Heart Mitochondria.  Ann NY Acad Sci 779:553-555.

  138. Jung DW, Panzeter E, Baysal K and Brierley GP. 1997.  On the Relationship between Matrix Free Mg2+ Concentration and Total Mg2+ in Heart Mitochondria.  Biochim Biophys Acta:1320:310-320. [Abstract] [PDF]

  139. Jung DW and Brierley GP. 1999.  Matrix Free Mg2+ and the Regulation of Mitochondrial Volume.  Am J Physiol 277:C1194-1201. [Abstract] [PDF]

BOOK CHAPTERS AND PUBLISHED REVIEWS:

  1. Brierley GP: 1963. Ion Accumulation in Heart Mitochondrial.  In Energy-Linked Functions of Mitochondria, B Chance (Editor).  Academic Press, NY, p237-251.

  2. Brierley GP: 1964.  Structure and Function of Heart Muscle Mitochondria.  Texas Rep Biol Med 22:823-835.

  3. Green DE and Brierley GP:  1965.  The Role of Coenzyme Q in Electron Transfer.  In Biochemistry of Quinones, RA Morton (Editor).  Academic Press, London p405-431.

  4. Green DE, Wharton DC, Tzagoloff A. Rieske J and Brierley GP. 1965.  The Mitochondrial Electron Transport Chain.  In An International Symposium on Oxidases and Related Oxidation-Reduction Systems, TE King, HA Mason and M Morrison (Editors).  Wiley, NY p1032-1076.

  5. Lessler MA and Brierley GP.  1969.  Oxygen Electrode Measurements in Biochemical Analysis.  In Methods of Biochemical Analysis.  D Glick (Editor).  Wiley NY p1-29.

  6. Brierley GP.  1974.  Passive Permeability and Energy-Linked Ion Movement in Isolated Heart Mitochondria.  Ann NY Acad Sci 227:398-411.

  7. Merola AJ, Fowler M, and Brierley GP.  1974.  N, N1Bis-dichloroacetamide Induction of Anion Permeability in Beef Heart Mitochondria.  In Myocardial Biology, NS Dhalla (Editor).  University Park Press, Baltimore p233-244.

  8. Brierley GP, Scott KM, Jurkowitz M and Merola AJ.  1974. Phosphate and Substrate Transport by Isolated Heart Mitochondria.  In Myocardial Biology, NS Dhalla (Editor) University Park Press, Baltimore p245-252.

  9. Brierley GP.  1976.  The Uptake and Extrusion of Monovalent Cations by Heart Mitochondria.  Mol Cell Biochem 10:41-62.

  10. Brierley GP.  1976.  Monovalent Cation Transport by Mitochondria.  In Mitochondria:  Biogenesis, Structure and Function, L Packer, A Gomez A Puyou (Editors).  Academic Press NY p3-20.

  11. Brierley GP.  1977.  Effects of Heavy Metals on Isolated Mitochondria.  In Biochemical Effects of Environmental Pollutants:&n