Patrice Hamel Receives Grant from OPBC
Co-PI Patrice Hamel has been awarded a grant from the Ohio Plant Biology Consortium entitled "Coiled-Coil Proteins in Organelle Biogenesis".

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UMDF Run Wild For the a Cure, 5K/1 Mile Walk to be Held on Saturday May 10, 2008 at Cleveland Metroparks Zoo
Please sign up to participate or offer a pledge for the United Mitochondrial Disease Foundation Run Wild for a Cure, 5K/1 Mile Walk to be held on Saturday, May 10, 2008 at Cleveland Metrooparks Zoo. This race raised money earmarked for research grants, raising awareness and for programs and services for affected families.

You can learn more by going to the website www.runwildforacure.org.

Periannan Kuppusamy Receives Grant from NIBIB
Periannan Kuppusamy has been awarded a grant from the NIBIB entitled "Noninvasive Monitoring of In Situ Oxygenation and Cell Therapy in Infarct Heart".

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NHLBI Grant Awarded to Yong Xia
Yong Xia received a grant from the NHLBI entitled "Endothelial Dysfunction in Postischemic Hearts".

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Denis Gutteridge Receives Grant from National Institute of Neurological Disorders and Stroke
Denis Gutteridge received a grant from the NINDS entitled "NF-kappaBeta Therapy for Duchenne Muscular Dystrophy". Duchenne Muscular Dystrophy (DMD) is the most frequent of all lethal X linked recessive disorders occurring n 1 of 3,500 boys.

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Elliot Crouser Receives Grant from American Thoracic Society
Elliott Crouser received a grant from the American Thoracic Society for an investigation entitled "Modulation of pulmonary sarcoidosis by nicotinic acetylcholine receptors.

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Chandan Sen has been named Associate Dean for Translational and Applied Research in OSUCM
Chandan Sen has been named Associate Dean for Translational and Applied Research in The Ohio State University College of Medicine. He also has been awarded a new RO1 from NIH entitled "Vitamin E Neuroprotection: Novel Molecular Mechanisms" that began in January 2008 to add to his other new NIH award of August 2007 entitled "Tissue oxygenation and wound angiogenesis".

Denis Gutteridge Receives NIH Grant
Denis Gutterridge received an NIH grant entitled "NF-KappaB/1KK Signaling in Myogenesis and Disease" with five years funding beginning in May, 2007. His research plans to establish the function of the classical pathway in a primary myogenic culture system, determine wether regulation of myogenesis by IKK beta and p65 is relevant in vivo; and determine the regulation and function of IKK alpha and the alternative pathway in skeletal muscle differentiation. This should provide insight in how these signaling pathways participate in the onset or progression of skeletal muscle disorders.

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Clay Marsh Selected to Board
Clay Marsh, MD was selected to serve on the External Advisory Board of the Battelle Memorial Institute's Biology and Science Initiative. Board members provide clinical insight into diagnostic and therapeutic needs in pulmonary disease, as well as scientific expertise in biomarker discovery, genetics of disease and relevant technologies. Additionally, he was appointed chair of the Stanley Sarnoff Cardiovascular Research Foundation Board of Directors. The foundation supports the early career development of cardiovascular scientists.

Position Announcement
Yale University School of Medicine, Department of Pathology is seeking two (2) postdoctoral associates in the laboratory of Gerald S. Shadel, Ph.D.  Two NIH-funded areas of investigation are currently ongoing aimed at understanding the role of mitochondria in human disease.

Crouser named to Editorial Board CCM
Elliott Crouser has been appointed to the Editorial Board of the journal Critical Care Medicine, which is a highly respected journal serving physicians and scientists with an interest in critical care. In 2007 he was appointed the acting Director of Research in the Critical Care Signature Program at the Ohio State University College of Medicine.

Pfeiffer Guest Speaker at IGR in Japan
The Institute for Genome Research at the University of Tokushima, Japan, held a symposium recently entitled "Understanding Health and Disease Through Functional Genomics". Occasions included the Institutes 10th anniversary and it's elevation to a National Center of Excellence by the Japanese government. Douglas Pfeiffer was an invited speaker at the symposium and was one of five brought in from outside Japan. His presentation was entitled “The Mitochondrial iPLA2 as a Potential Target for Drug Development Directed at Controlling the Permeability Transition”.

NIH/NHLBI Grant for Rita Alevriadou
The goal of this project is to characterize the mitochondrial (dys)function in cultured coronary arterial endothelial cells exposed to either fluid shear stress or an in vitro protocol of ischemia/reperfusion and to test potential therapeutic strategies, such as mitochondria-targeted antioxidants, that may protect the coronary endothelium from reperfusion injury.

NHLBI Grant for Yeong-Renn Chen
Yeong-Renn Chen recently received a five year NIH grant entitled "Myocardial Injury Associated with Mitochondria-derived Oxygen Free Radical(s)". This grant was funded by the National Heart, Lung, and Blood Institute.

TSFRE Grant for Juan Crestanella
Juan Crestanella recently received a two year TSFRE grant entitled "Post Conditioning, Free Oxygen Radical Generation and Mitochondrial Function". This grant was funded by the Thoracic Surgery Foundation for Research and Education.

Alcon Laboratories Inc. Grant to Pfeiffer
Nonsteriodal anti-inflammatory drugs (NSAIDs) have many applications in medicine, including their use topically to alleviate pain and inflammation in the eye. As a new phase of our collaborations with Alcon Laboratories we are investigating the potential of these compounds to promote mitochondrial dysfunction. The goal is to reveal particular members of the NSAIDs family which have a minimum potential to generate toxicity and attendant side effects in an ocular environment.