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Center for RNA Biology Publications

Ohio State University has a large concentration of research labs with interests in RNA research. These laboratories constitute an interdisciplinary group focused on the biochemistry, molecular biology, structure and function of RNA. Organizing RNA research in this manner facilitates sharing of reagents and technologies, collaborations and joint research grants, expanded course offerings, and expanded opportunities for trainees to develop their research careers. In 2005, research expenditures for the RNA group totaled $5.7 million, resulting in 55 publications. Over the past three years, members of the RNA group have published in the most prestigious scientific journals including:

  • Aittaleb M, Rashid R, Chen Q, Palmer JR, Daniels CJ, Li H. (2003) Structure and function of archaeal box C/D sRNP core proteins. Nat Struct Biol. 10:256-63.

  • Arnold J, Yamamoto B, Li M, Phipps AJ, Younis I, Lairmore MD, Green PL. (2006) Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1. Blood. 107:3976-82.

  • Artsimovitch I, Vassylyeva MN, Svetlov D, Svetlov V, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Tahirov TH, Vassylyev DG. (2005) Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell. 122:351-63.

  • Blight SK, Larue RC, Mahapatra A, Longstaff DG, Chang E, Zhao G, Kang PT, Green-Church KB, Chan MK, Krzycki JA. (2004) Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo. Nature. 431:333-5.

  • Boomershine WP, McElroy CA, Tsai HY, Wilson RC, Gopalan V, Foster MP. (2003) Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P. Proc Natl Acad Sci U S A. 100:15398-403.

  • Burckin T, Nagel R, Mandel-Gutfreund Y, Shiue L, Clark TA, Chong JL, Chang TH, Squazzo S, Hartzog G, Ares M Jr. (2005) Exploring functional relationships between components of the gene expression machinery. Nat Struct Mol Biol. 12:175-82.

  • Fuchs RT, Grundy FJ, Henkin TM. (2006) The S(MK) box is a new SAM-binding RNA for translational regulation of SAM synthetase. Nat Struct Mol Biol. 13:226-33.

  • Grundy FJ, Lehman SC, Henkin TM. The L box regulon: lysine sensing by leader RNAs of bacterial lysine biosynthesis genes. Proc Natl Acad Sci U S A. 14;100:12057-62.

  • Hartman TR, Qian S, Bolinger C, Fernandez S, Schoenberg DR, Boris-Lawrie K. RNA helicase A is necessary for translation of selected messenger RNAs. Nat Struct Mol Biol. 13:509-16.

  • Jin Y, Cowan JA. (2006) Targeted cleavage of HIV rev response element RNA by metallopeptide complexes. J Am Chem Soc. 128:410-1.

  • Liu T, Bundschuh R. (2005) Model for codon position bias in RNA editing. Phys Rev Lett. 95:088101.

  • McGarry KG, Walker SE, Wang H, Fredrick K. (2005) Destabilization of the P site codon-anticodon helix results from movement of tRNA into the P/E hybrid state within the ribosome. Mol Cell. 20:613-22.

  • Rinehart J, Krett B, Rubio MA, Alfonzo JD, Soll D. (2005) Saccharomyces cerevisiae imports the cytosolic pathway for Gln-tRNA synthesis into the mitochondrion. Genes Dev. 19:583-92.

  • Roy H, Ling J, Irnov M, Ibba M. (2004) Post-transfer editing in vitro and in vivo by the beta subunit of phenylalanyl-tRNA synthetase. EMBO J. 23:4639-48.

  • Sauerwald A, Zhu W, Major TA, Roy H, Palioura S, Jahn D, Whitman WB, Yates JR 3rd, Ibba M, Soll D. (2005) RNA-dependent cysteine biosynthesis in archaea. Science. 307:1969-72.

  • Vassylyev DG, Svetlov V, Vassylyeva MN, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Artsimovitch I. (2005) Structural basis for transcription inhibition by tagetitoxin. Nat Struct Mol Biol. 12:1086-93.

  • Wilson RC, Bohlen CJ, Foster MP, Bell CE. (2006) Structure of Pfu Pop5, an archaeal RNase P protein. Proc Natl Acad Sci U S A. 103:873-8.

  • Yang F, Schoenberg DR. (2004) Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA. Mol Cell. 14:435-45.

  • Yassin A, Fredrick K, Mankin AS. (2005) Deleterious mutations in small subunit ribosomal RNA identify functional sites and potential targets for antibiotics. Proc Natl Acad SciU S A. 102:16620-5.