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The researcher will work in the field of mitochondria biogenesis and study the assembly process of c-type cytochromes, a class of hemoproteins with covalent attachment of the heme co-factor to a CXXCH motif on the apocytochrome. Cytochromes c are versatile molecules that function in electron transfer reactions but also in signaling the death pathways. Their assembly process is not understood and in humans mutations in the only known cytochrome c assembly factor cause a neurodevelopmental disease with cardiomyopathic manifestations.
The future hire will use yeast as an experimental system and focus on 1) elucidating the biochemical activity of Cyc2p a novel mitochondrial flavoprotein that controls a yet-to-be-defined redox step in the heme attachment reaction to apocytochrome and 2) identifying additional mammalian cytochrome-c assembly factors. Because we suspect a role of Cyc2p in thiol-based chemistry, the researcher will also take part in on-going genetic experiments to 3) further dissect the pathway(s) that operate in intermembrane thiol-based redox chemistry. Thiol-based chemistry in the mitochondrial intermembrane space is a recent and novel development in the field since the discovery of catalysts that promote disulfide bond formation. Molecular genetics and biochemical approaches will be used to answer the scientific questions we are interested in. Interested candidates should send a cover letter, resume, and a list of three referees to Dr. Patrice Hamel at hamel.16@osu.edu. Use Post-doctoral Position in the subject line. For additional information, see also Dr. Hamel's Web Site.
We are pleased to announce that Erich Grotewold has been awarded another new grant. This is a 3-year award from the US-Israeli Binational Agricultural Research and Development Fund. It is in the amount of $137,000 and is entitled "Regulation of tomato fruit development by interacting MYB proteins."
Erich Grotewold has been awarded 3-year grant in the amount o $449,390 from the DOE, entitled "Engineering phenolic metabolism in the grasses using transcription factors."
Erich has also been awarded a second, major grant from NSF (Plant Genome). It is a 3-year award in the amount of $2,479,632 entitled "The Grass Regulome Initiative: Integrating control of gene expression and agronomic traits across the grasses.
David Somers’ group has published an article in Nature (Sept. 20) entitled, “ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light.” Woe-Yeon Kim and Sumire Fujiwara are co-first authors.
Erich Grotewold has been awarded a grant from the USDA in the amount of $201,025 for a two-year study entitled, “Transposons as gene control elements.”
Rebecca Lamb has received an award of $57,567 over two years from the OPBC for a study entitled, ”Two Arabidopsis WWE-PARP proteins involved in abiotic stress response and development.”
Follow the link below for a schedule of informal 30-40 min seminars that
will take place at noon on Fridays in room 189 of Rightmire Hall.
Schedule
[pdf]
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The Ohio State University • Department of Plant Cellular and Molecular
Biology
500 Aronoff Laboratory • 318 West 12th Avenue • Columbus
Ohio 43210
Ph: 614.292.8952 | Fax: 614.292.6345
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