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Dept of Molecular Genetics |
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My major research interest is the microtubule cytoskeleton which is essential for mitosis, meiosis, the maintenance of cell shape and many forms of motility. My lab is using a combination of genetic, molecular genetic, morphological and biochemical techniques to study these phenomena in the filamentous fungus Aspergillus nodulans and in other organisms. Our most notable discovery has been gamma tubulin, a protein that is related to the major microtubule proteins alpha and beta tubulin. Gamma tubulin is present in all eukaryotes and is located at microtubule organizing centers. We have demonstrated that gamma tubulin is essential for the formation of mitotic spindles and we are currently investigating other aspects of gamma tubulin function including the role of gamma tubulin in the regulation of microtubule assembly. |
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