There are two immediate openings for motivated scientists to conduct research into exciting biochemical problems in an active multidisciplinary setting. Projects are available to study the structural and dynamic basis of molecular recognition, enzyme catalysis and gene regulation. Funded projects involve use of biochemical and biophysical techniques to characterize protein-ligand, protein-protein, protein-nucleic acid (DNA, RNA), and RNA-ligand interactions. A primary objective is the use of NMR spectroscopy and other biophysical methods to characterize the structures and dynamic behavior of biomolecules.
The laboratory is well equipped for structural studies, with access to NMR spectrometers operating at 600 and 800 MHz, advanced computing hardware and associated software, as well as general biochemical and biophysical tools.
Qualified individuals will hold a PhD, a strong publication record, and background in at least two of the following areas: protein engineering (recombinant DNA, site-directed mutagenesis), protein overexpression and purification (ion exchange, size exclusion, affinity chromatography, HPLC/FPLC), kinetics, calorimetry, multidimensional biomolecular NMR spectroscopy, x-ray crystallography and computer-aided structure determination.
Interested individuals should send a cover letter, CV and list of publications, and arrange to have three letters of recommendation sent to:
Prof. Mark P. Foster
Department of Biochemistry
The Ohio State University
484 West 12th Ave.
Columbus, OH 43210
Phone: 614-292-1377
FAX: 614-292-6773
Foster.281@osu.edu
http://www.biosci.ohio-state.edu/~mfoster/
Posted May 9, 2008